NeuroCure Clinical Research Center
Charité Campus Mitte
Tel: +49 (0)30 450 539 705
Fax: +49 (0)30 450 539 915
friedemann.paul@charite.de
Experimental and Clinical Research Center
Lindenberger Weg 80
13125 Berlin
Wir arbeiten dabei mit einem translationalen Ansatz; das bedeutet, dass wir versuchen, neue Entwicklungen und Erkenntnisse aus der Forschung unmittelbar in die klinische Arbeit zu überführen.
Die AG Klinische Neuroimmunologie ist eine von vier Arbeitsgruppen am NeuroCure klinischen Forschungszentrum (NCRC).
Hier finden Sie die Pressemitteilung zu unseren neuesten Ergebnissen.
Berlin Registry of Neuroimmunological Entities (BERLimmun) - a monocentric prospective observational study on the long-term course of neuroimmunological diseases.
Sponsor: IIT
Recruitment: yes
Local PI: PD Dr. Tanja Schmitz-Hübsch
Study Number: German Clinical Trial Register DRKS00026761
Acute Optic Neuritis Study (AON-S), a monocentric, prospective observational study on symptomatology, diagnosis, therapy and prognosis of acute optic neuritis.
Sponsor: IIT
Recruitment: yes
Local PI: Dr. Susanna Asseyer/Prof. Dr. Friedemann Paul
Study Number: NCT05605951
Neural mechanisms of mental and emotional processes in multiple sclerosis and their relevance to disease severity.
Sponsor: IIT
Recruitment: yes
Local PI: PD Dr. Martin Weygandt
A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with nonrelapsing secondary progressive multiple sclerosis (HERCULES).
Sponsor: Sanofi
Recruitment: Screening closure 29.11.2022
Local PI: Prof. Dr. Friedemann Paul
Study Number: EudraCT 2020-000647-30
A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with primary progressive multiple sclerosis (PERSEUS).
Sponsor: Sanofi
Recruitment: yes
Local PI: Prof. Dr. Friedemann Paul
Study Number: EudraCT 2020-000645-14
Sponsor: IIT
Recruitment: yes
Local PI: Prof. Dr. Stefan Gold
Clinical validity of confirmed disease progression defined by marker-less home-based assessment of motor function in multiple sclerosis (HOPE-MS).
Sponsor: IIT (Celgene)
Recruitment: yes
Local PI: PD. Dr. Tanja Schmitz-Hübsch
Tracking the immune response to SARS-CoV-2 modRNA vaccines in an open-label multicenter study in participants with relapsing multiple sclerosis treated with ofatumumab s.c. (KYRIOS).
Sponsor: Novartis
Recruitment: closed
Local PI: Prof. Dr. Friedemann Paul
A phase III, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of satralizumab as monotherapy or in addition to baseline therapy in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).
Sponsor: Roche
Recruitment: yes
Local PI: PD. Dr. Tanja Schmitz-Hübsch
Study Number: NCT05271409
A Randomized, double-blind, Placebo-controlled, multicenter Phase 3 pivotal study to evaluate the efficacy and safety of rozanolixizumab to treat adult patients with Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-Associated Disease (MOG-AD).
Sponsor: UCB
Recruitment: yes
Local PI: Prof. Dr. Friedemann Paul
Study number: NCT05063162
Sensitivity of quantitative motor performance measures in multiple sclerosis – a prospective cohort study over two years using Microsoft Kinect.
Sponsor: IIT
Recruitment: closed
Local PI: Prof. Dr. Friedemann Paul
7 Tesla MRI in patients with multiple sclerosis and other neuroimmunological disorders.
Sponsor: IIT
Local PI: Prof. Dr. Friedemann Paul
Prevention of paclitaxel-related neurologic adverse events with lithium - a randomized, double-blind, placebo-controlled, exploratory proof-of-concept phase II clinical trial for the prevention of chemotherapy-induced neurotoxicity.
Sponsor: IIT
Recruitment: yes
Local PI: Prof. Dr. Mathias Endres
MR elastography in patients with multiple sclerosis.
Sponsor: IIT
Local PI: Prof. Dr. Ingolf Sack
Sponsor: IIT
Recruitment: yes
Local PI: Prof. Dr. Stefan Gold/Prof. Dr. Isabel Dziobek
Database on family planning and pregnancies in multiple sclerosis and Neuromyelitis optica spectrum disease (PreCoMS).
Sponsor: IIT
Local PI: Prof. Dr. Friedemann Paul
Specified laboratory investigations in Portugal.
Sponsor: IIT
Recruitment: yes
Local PI: Prof. Dr. Friedemann Paul
Regulatory T cells in Neuromyelitis optica.
Sponsor: IIT
Recruitment: yes
Local PI: Dr. Maria Hastermann
Determining the accuracy, reliability, validity, and responsiveness of video-operceptive motion analysis with Microsoft Kinect - VALKINECT.
Sponsor: IIT
Recruitment: yes
Local PI: Prof. Dr. Friedemann Paul
Care Model for Patients with Chronic Fatigue Syndrome (ME/CFS).
Sponsor: IIT
Recruitment: yes
Local PI: Prof. Dr. Carmen Scheibenbogen
Patient registry of the German Multiple Sclerosis Society, Federal Association (DMSG) within the MS Research and Project Development GmbH (MSFP), DMSG MS-Register.
Sponsor: DMSG
Recruitment: yes
Local PI: Prof. Dr. Friedemann Paul
Family planning and pregnancies in multiple sclerosis (PreCoMS)
Sponsor: IIT
Recruitment: yes
Local PI: Dr. Nadja Siebert
Study Number: NCT05010902
Analysis of the Pathophysiology and Pathology of Corona Virus Disease 2019 (Pa-COVID-19).
Sponsor: IIT
Recruitment: yes
Local PI: Prof. Carmen Scheibenbogen / Dr. Judith Bellmann-Strobl
Dynamic vascular analysis of the retina in the Pa-COVID-19 study.
Sponsor: IIT
Recruitment: yes
Local PI: Prof. Dr. Friedemann Paul
A study to investigate improvement in physical function in SF-36 with Vericiguat compared with Placebo in participants aged 18 to 50 years with post-COVID-19 syndrome (PCS and PCS/CFS).
Sponsor: IIT (Bayer)
Recruitment: yes
Local PI: Dr. Judith Bellmann-Strobl
Study Number: EudraCT 2021-005494-11 NCT05697640