23Na magnetic resonance imaging of tissue sodium
Autor/innen
- C. Kopp
- P. Linz
- L. Wachsmuth
- A. Dahlmann
- T. Horbach
- C. Schoefl
- W. Renz
- D. Santoro
- T. Niendorf
- D.N. Mueller
- M. Neininger
- A. Cavallaro
- K.U. Eckardt
- R.E. Schmieder
- F.C. Luft
- M. Uder
- J. Titze
Journal
- Hypertension
Quellenangabe
- Hypertension 59 (1): 167-172
Zusammenfassung
Hypertension is linked to disturbed total-body sodium (Na(+)) regulation; however, measuring Na(+) disposition in the body is difficult. We implemented (23)Na magnetic resonance spectroscopy ((23)Na-MR) and imaging technique ((23)Na-MRI) at 9.4T for animals and 3T for humans to quantify Na(+) content in skeletal muscle and skin. We compared (23)Na-MRI data with actual tissue Na(+) content measured by chemical analysis in animal and human tissue. We then quantified tissue Na(+) content in normal humans and in patients with primary aldosteronism. We found a 29% increase in muscle Na(+) content in patients with aldosteronism compared with normal women and men. This tissue Na(+) was mobilized after successful treatment without accompanying weight loss. We suggest that, after further refinements, this tool could facilitate understanding the relationships between Na(+) accumulation and hypertension. Furthermore, with additional technical advances, a future clinical use may be possible.