Alternatives Spleißen im Herzen [Alternative splicing in the heart]

Alternative splicing is an important post-transcriptional regulatory mechanism that is implicated in development, tissue specific gene expression and disease processes, also in the heart. Splicing factors regulate this process. Next generation sequencing can be used to quantify genome wide alternative splicing and to elucidate the underlying mole - cular mechanism of factors such as RBM20, a key player in cardiac specific transcript processing.