A cFLIP-flop switch for senolysis
Autor/innen
- D.N.Y. Fan
- C.A. Schmitt
Journal
- Nature Cancer
Quellenangabe
- Nat Cancer 3 (11): 1279-1281
Zusammenfassung
Persistent senescent cancer cells have tumor-promoting potential, making their selective elimination a prime therapeutic objective. The death receptor inhibitor cFLIP has now been shown to counter the susceptibility of senescent cells to DR5-mediated extrinsic apoptosis, which can be therapeutically exploited.