Detailing intra-lesional venous lumen shrinking in multiple sclerosis investigated by sFLAIR MRI at 7-T

Autor/innen

  • K. Mueller
  • J. Kuchling
  • J. Doerr
  • L. Harms
  • K. Ruprecht
  • T. Niendorf
  • J. Wuerfel
  • F. Paul
  • T. Sinnecker

Journal

  • Journal of Neurology

Quellenangabe

  • J Neurol 261 (10): 2032-2036

Zusammenfassung

  • Intra-lesional venous lumen shrinking detectable by MRI was suggested as an in vivo marker of inflammation in multiple sclerosis (MS). In our study mean diameters of pre-, post- and intra-lesional venous sections were determined in 49 patients with MS or clinically isolated syndrome (CIS) using a pixel-wise analysis on susceptibility-weighted fluid-attenuated inversion recovery (sFLAIR) images and T2*-weighted (T2*w) imaging at 7 Tesla (T). We observed post-to-intra-lesional venous lumen shrinking on T2*w images (p = 0.036) in an analysis of 338 venous sections. Pre-to-intra-lesional venous lumen reduction was only detectable in less than 50 % of lesions and failed statistical significance when analysing T2*w (p = 0.325) and sFLAIR images (p = 0.258). In conclusion, thinning of intra-lesional veins in MS is-if detectable at all-probably less severe than previously reported, and affects only a minority of MS lesions.


DOI

doi:10.1007/s00415-014-7460-2