Hold me, but not too tight - endothelial cell-cell junctions in angiogenesis
- A. Szymborska
- H. Gerhardt
- Cold Spring Harbor Perspectives in Biology
- Cold Spring Harb Perspect Biol 10 (8): a029223
Endothelial cell-cell junctions must perform seemingly incompatible tasks during vascular development-providing stable connections that prevent leakage, while allowing dynamic cellular rearrangements during sprouting, anastomosis, lumen formation, and functional remodeling of the vascular network. This review aims to highlight recent insights into the molecular mechanisms governing endothelial cell-cell adhesion in the context of vascular development.