Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations
Autor/innen
- K. Nimptsch
- K. Aleksandrova
- V. Fedirko
- M. Jenab
- M.J. Gunter
- P.D. Siersema
- K. Wu
- V. Katzke
- R. Kaaks
- S. Panico
- D. Palli
- A.M. May
- S. Sieri
- B. Bueno-de-Mesquita
- K. Standahl
- M.J. Sánchez
- A. Perez-Cornago
- A. Olsen
- A. Tjønneland
- C.B. Bonet
- C.C. Dahm
- M.D. Chirlaque
- V. Fiano
- R. Tumino
- A. Barricarte Gurrea
- M.C. Boutron-Ruault
- F. Menegaux
- G. Severi
- B. van Guelpen
- Y.A. Lee
- T. Pischon
Journal
- BMC Cancer
Quellenangabe
- BMC Cancer 22 (1): 695
Zusammenfassung
BACKGROUND: The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear. METHODS: We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression. RESULTS: During a median follow-up of 9.3 years, 455 CRC-specific deaths were recorded, out of 590 deaths from all causes. Pre-diagnostic CRP concentrations were not associated with CRC-specific (hazard ratio, HR highest versus lowest quintile 0.92, 95% confidence interval, CI 0.66, 1.28) or all-cause mortality (HR 0.91, 95% CI 0.68, 1.21). Genetic predisposition to higher CRP (weighted score based on alleles of four CRP SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per CRP-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). Among four investigated CRP genetic variants, only SNP rs1205 was significantly associated with CRC-specific (comparing the CT and CC genotypes with TT genotype, HR 0.54, 95% CI 0.35, 0.83 and HR 0.58, 95% CI 0.38, 0.88, respectively) and all-cause mortality (HR 0.58, 95% CI 0.40, 0.85 and 0.64, 95% CI 0.44, 0.92, respectively). CONCLUSIONS: The results of this prospective cohort study do not support a role of pre-diagnostic CRP concentrations on mortality in individuals with CRC. The observed associations with rs1205 deserve further scientific attention.