Berlin: Markus Schülke-Gerstenfeld, MD, Prof.
Paris / Versailles: Helge Amthor, MD, Prof. / Luis Garcia, PhD, Prof.
In normal individuals, several signaling molecules of the transforming growth factor beta (TGF-β) family, most notably myostatin, restrict the size of skeletal muscle. The precise function of myostatin remains unclear. We hypothesize that myostatin optimizes function and metabolism of skeletal muscle. Most previous work exploring the function of myostatin has been performed on constitutive myostatin knockout mice, which does not permit a differentiation between the prenatal or postnatal effect of myostatin deficiency. Moreover, up to date, the role of myostatin on muscle function and metabolism has only been explored in lack-of-function models. Our aim is to determine the function of myostatin on skeletal muscle physiology and metabolism in adult wildtype mice using gain-of-function and loss-of-function models. We will therefore be able judge the effect of myostatin modulation in the context of novel biotherapies and also in the context of a potential abuse for athletic "doping" purposes. To this end, we will directly compare the effect of myostatin induced muscle hypotrophy (treatment with recombinant myostatin) with the effect of myostatin blockade induced muscle hypertrophy (treatment with AAV myostatin propeptide). We will compare the effect on force generation, exercise capacity, oxidative muscle metabolism, muscle morphometry and cellular properties.
Theses in progress
University of Leeds, UK
|Involvement of BMP signaling in neuromuscular disorders with skeletal muscle atrophy and arthrogryposis multiplex congenita (AMC)
MyoGrad PhD student from
Defence and degree
|Gabriella Dias Florencio Leite
RNA splicing modulation strategies as therapeutic approaches for the treatment of neuromuscular disorders
Defence on Sept. 28, 2017 in Versailles
|The influence of Notch over-stimulation on muscle stem quiescence versus proliferation, and on muscle regeneration
Defence on Sept. 30, 2015 in Berlin
|Generation and characterization of a DmdEGFP reporter mouse as a tool to investigate dystrophin expression
Defence on Feb 5, 2016 in Berlin
|The function of activin receptor type IIB signaling in adult skeletal muscle
Defence on July 07, 2014 in Berlin
|BMP-signaling controls postnatal muscle development
Defence on Sept. 29, 2015 in Paris