Dea Slade: PHF3 couples transcription regulation with mRNA stability through the new Pol II CTD reader domain SPOC

Dea Slade will talk about unpublished work on the new transcription regulator PHF3, which uses the new CTD reader domain SPOC to dock onto Pol II and regulate transcription and mRNA stability. After the talk there are four 30min slots reserved for for discussion.

Dea Slade is a group leader at Max Perutz Lab within Vienna Biocenter. She studies DNA damage response and transcription regulation in mammalian cells, with a particular focus on the regulation of protein-protein interactions by post-translational modifications such as phosphorylation, poly(ADP-ribosyl)ation and acetylation. Prior to becoming a group leader she worked on DNA repair in Deinococcus radiodurans as a PhD student at Paris University Pierre et Marie Curie and structurally characterized poly(ADP-ribose) glycohydrolases during her postdoc at the Paterson Institute in Manchester.