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Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbrück Center now report in “Science Immunology.”

Melissa Birol of the Max Delbrück Center is looking to understand early stages of Alzheimer’s disease. Her focus is on the interplay between the lipid metabolism of nerve cells and the spread of tau protein. The Alzheimer Research Initiative is funding her work with 193,500 euros.

The Einstein Center 3R will continue for a second funding period. Following a successful interim evaluation, the board of the Einstein Foundation Berlin has approved funding for a further two and a half years for research into alternatives to animal testing. Partners include the Max Delbrück Center.

A tumor often arises when cancer genes multiply. In this process, additional genes act as hitchhikers, potentially creating previously unknown vulnerabilities that open the door to new therapeutic approaches. This finding is reported by a team led by ECRC-scientists Anton Henssen and Jan Dörr in "Cancer Discovery."

Scientific infrastructure is highly specialized and energy-intensive. During a kick-off event of the Helmholtz Competence Network for Climate-Friendly Construction in Berlin, experts from both the Helmholtz centers and the construction industry discussed how it can be designed to be climate-friendly.

Organoids help researchers understand biological processes in health and in disease. It is, however, difficult to influence the way in which they organize themselves into complex tissues. Now a group led by Nikolaus Rajewsky has found a new way to do so. They report their work in Nature Methods.

Internationally renowned for pioneering achievements and geared to inter-institutional cooperation: 22 research groups at the Berlin Institute for Medical Systems Biology in the Max Delbrück Center (MDC-BIMSB) explore how genes regulate life. It is now celebrating its 15th birthday.

Data science has long been part of our research – including artificial intelligence. However, AI has also permeated the daily lives of many people. At "Insights," we were curious: What books would ChatGPT & Co. recommend for laypeople interested in molecular medicine? The result: three bestsellers.

With a grant of 600,000 euros, the Einstein Foundation Berlin is funding the preliminary module for an Einstein Center for Early Disease Interception. Ten Berlin institutions – including the Max Delbrück Center – are looking to develop, integrate and apply the technologies needed for precision medicine more quickly.

Using single-cell technologies, Maike Sander and colleagues have observed a shift in the relative abundance of the two subtypes of pancreatic beta cells as type 2 diabetes unfolds. This knowledge could be leveraged to find novel drugs, they report in “Nature Genetics.”