Antibodies and Complement Conference

May 20, 2019, 2:00pm - May 25, 2019, 2:00pm

The antibody response and the complement system are major effector arms of the immune system. Both have been involved in a plethora of pathological conditions, including autoimmunity, allergy, infections and cancer. Antibodies and complement components regulate, mainly through their receptors (FcR and CR respectively) cell activation, ADCC, ADCP, CDC, CDCP, migration, survival but also, as recently described, metabolism. As the portfolio of antibody—and complement-effector function grow, high-end technological solutions are developed and novel therapeutic applications are proposed.

This 2^nd conference on Antibodies & Complement will focus attention on key advances in both fields with the aim at fostering discussions between antibody experts and complement experts. Some of the critical topics to be covered include:

antibody & complement (novel) functions
human antibody repertoires
complement structure and subcellular localization
novel technologies
complement and antibody therapies

After the success of the first edition, this second edition of conference on Antibodies & Complement should again be a forum for leaders in the field and new investigators coming from academia, industry and research institutes to discuss where the field is going and what challenges lie ahead.

Venue

Hotel Eden Roc
Punta de Port Salvi, s/n

17220 Sant Feliu de Guíxols Girona
Spain

Time

May 20, 2019, 2:00pm - May 25, 2019, 2:00pm

Catering

Coffee breaks; lunch and dinner buffet

Hashtag

#AntibodiesComplement19

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Program

Program Antibodies & Complement_1.pdf (PDF, 664.51 KB)

Poster Abstracts_0.pdf (PDF, 603.46 KB)

14:00	Registration
16:30	Welcome & Introductions by Pierre Bruhns & Kathrin de la Rosa

Antibodies & Complement I

Chairs

Pierre Bruhns, Institut Pasteur, Paris, France
Kathrin de la Rosa, Max Delbrück Center for Molecular Medicine, Berlin, Germany

16:40	Michael Carroll, Harvard Medical School, Massachusetts, USA Complement in adaptive immunity
17:20	Selected abstract: Christian Lehmann, University Hospital Erlangen, Germany Antigen targeting of Fc receptors induces strong and functional relevant T cell responses in vivo independent of ITAM signaling but dependent on dendritic cell subsets
17:40	Selected abstract: Kasia Kready, Institut Pasteur, Paris, France Tracking Temporal and Spatial Affinity Maturation of Antibodies from Single-Cells in a mouse model of autoimmunity
17:55	Selected abstract: Steven de Taeye, Sanquin, Amsterdam, The Netherlands Polymorphic variant of IgG2 is less efficient in complement activation
18:10	Brinda Prasad, Regeneron Pharmaceuticals, New York, USA Enhancing Pathogen and Cellular Clearance with Bispecific C1q Antibody
19:00	Welcome Reception – Networking
20:00	Dinner

Antibodies & Complement II

Chairs

Suzan Rooijakkers, University Medical Center Utrecht, The Netherlands
Falk Nimmerjahn, FAU Erlangen-Nuremberg, Germany

09:00	Janine Schuurman, Genmab, Utrecht, The Netherlands Translating basic science to antibody therapeutics
09:40	Selected abstract: Jürgen Strasser, University of Applied Sciences Upper Austria, Linz, Austria The molecular pathways of IgG oligomerization and classical complement activation on antigenic surfaces
10:00	Selected abstract: Ben Goldberg, Dartmouth College, Hanover, USA Squaring in vitro complement assays with in vivo results: case studies in anti-HIV-1 complement activity
10:15	Selected abstract: Seline Zwarthoff, UMC, Utrecht, The Netherlands Proteases C1r and C1s affect binding of C1q to certain human IgG subclasses
10:30	Coffee break
11:00	Heidi Ling, Imperial College, London, UK Complement in autoimmune diseases
11:40	Selected abstract: Eva Conde Garcia, Institut Pasteur, Paris, France Anti-IL-4 and anti-IL-13 dual vaccination using Kinoid technology prevents development of allergic airway inflammation in mice
12:00	Selected abstract: Cécile Bergua, IRIB Normandy, Rouen, France In vivo pathogenicity of IgG from patients with anti-SRP or anti-HMGCR autoantibodies in immune-mediated necrotising myopathy
12:15	Selected abstract: Pablo Canales Herrerias, Institut Pasteur, Paris, France Characterizing autoantibody-producing cells in thrombocytopenic patients for secretion rate and affinity for a platelet autoantigen
12:30	Lunch and social time

Chairs

Pierre Bruhns, Institut Pasteur, Paris, France
Janine Schuurman, Genmab, Utrecht, The Netherlands

15:00	Ron Taylor, University of Virginia, USA The mechanism of antibody-induced complement-mediated lysis of tumor cells
15:40	Selected abstract: Haoyang Zhuang, University of Florida, USA A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM
15:55	Selected abstract: Simone Oostindie, Genmab, Utrecht, The Netherlands DuoHexaBody-CD37: a novel CD37-specific antibody that demonstrates superior complement-dependent cytotoxicity in pre-clinical B-cell malignancy models
16:10	Marjolein van Egmond, VU University Medical Center Amsterdam, The Netherlands IgA therapeutic antibodies
16:50	Selected abstract: Sina Bondza, Uppsala University, Sweden Characterization of Rituximab and C1q interactions on living cells in real-time
17:05	Selected abstract: Delphine Sterlin, Institut Pasteur, Paris, France Human IgA coat a wide range of gut commensals
17:30	Poster Session I
20:00	Dinner

Antibodies in infectious diseases

Chairs

Kathrin de la Rosa, Max Delbrück Center for Molecular Medicine, Berlin, Germany
Bart Bardoel, University Medical Center Utrecht, The Netherlands

09:00	Davide Corti, VIR, Bellinzona, Switzerland Novel therapeutic antibodies in infectious diseases
09:40	Selected abstract: Leire Aguinagalde, UMC, Utrecht, The Netherlands Complement-enhancing monoclonal antibodies as a therapeutic strategy against Streptococcus pneumoniae
10:00	Selected abstract: Elizabeth Aitken, University of Melbourne, Australia Identifying functional antibodies that protect pregnant women against placental malaria infection
10:15	Selected abstract: Harry Schroeder, University of Alabama at Birmingham, USA Pneumococcal vaccination elicits public B-cell repertoires and serum antibody clonotypes derived from the IgM+IgD+CD27+ memory B cell compartment
10:30	Coffee break
11:00	Tineke Cantaert, Institut Pasteur, Phnom Penh, Cambodia Protective antibody response in dengue infections
11:40	Selected abstract: Timothée Bruel, Institut Pasteur, Paris, France Complement activation at the surface of HIV-1-infected cells
12:00	Selected abstract: Priscilla Kerkman, UMC, Utrecht, The Netherlands Extracellular ATP can mediate cleavage of CD27 to generate CD27-IgD- B cells in circulation of hantavirus patients
12:15	Florian Krammer Icahn School of Medicine at Mount Sinai, New York, USA Antibody responses to conserved influenza virus epitopes
12:55	Lunch and social time

Chairs

Falk Nimmerjahn, FAU Erlangen-Nuremberg, Germany
Florian Krammer, Icahn School of Medicine at Mount Sinai, New York, USA

18:00	Christian Busse, German Cancer Research Center, Heidelberg, Germany Anti-malaria Abs and repertoires analysis
18:40	Selected abstract: Peter Rice, UMASS, Massachusetts, USA Complement alone drives efficacy of a chimeric anti-gonococcal monoclonal antibody
19:00	Selected abstract: Timon Damelang, University of Melbourne, Australia Importance of functional antibodies in protection of pregnant women from malaria
19:15	Taia Wang, Stanford University, USA Fucosylation on anti-dengue antibodies
20:00	Dinner

Complement

Chairs

Suzan Rooijakkers, University Medical Center Utrecht, The Netherlands
Doryen Bubeck, Imperial College, London, UK

09:00	Piet Gros, Utrecht University, The Netherlands Antibody and complement structures
09:40	Selected abstract: Ravit Netzer, Weizmann Institute of Science, Rehovot, Israel Automated design of ultrahigh specificity protein binders
10:00	Selected abstract: Rolf Spirig, CSL Behring AG, Bern, Switzerland Inhibition of Ab-complex mediated inflammation by recombinant IgG1 Fc hexamer
10:15	Selected abstract: Dennis Doorduijn, UMC, Utrecht, The Netherlands Bacterial killing by MAC pores requires immediate assembly of C5b-7
10:30	Coffee break
11:00	Daniel Ricklin, University Basel, Switzerland The Renaissance of Complement Therapeutics: Taming a Host Defense Pathway Gone Astray
11:40	Selected abstract: Alex Macpherson, UCB Pharma, Slough, UK A VHH-assisted study of the C5 inhibitory mechanisms of OmCI and RaCI
11:55	Selected abstract: Immaculada Margarit Y Ros, GSK Vaccines, Siena, Italy The Streptococcus agalactiae CIP Complement Inhibitory Protein at the interface between innate and acquired immunity
12:10	Selected abstract: Dani Heesterbeek, UMC, Utrecht, The Netherlands Disruption of Gram-negative bacteria by human serum requires complement and lysozyme
12:25	Lunch and social time

Chairs

Pierre Bruhns, Institut Pasteur, Paris, France
Daniel Ricklin, University Basel, Switzerland

15:00	Doryen Bubeck, Imperial College, London, UK Cryo-EM structures of MAC
15:40	Claudia Kemper, National Institutes of Health, Bethesda, USA Unexpected roles for the complosome in cell metabolism
16:20	Michel Cogné, University of Limoges, France IgG5, the new human IgG subclass
17:30	Poster Session II
20:00	Dinner

Antibody Features

Chairs

Kathrin de la Rosa, Max Delbrück Center for Molecular Medicine, Berlin, Germany
David Humphreys, UCB Pharma, Slough, UK

09:00	Sarel J. Fleishman, Weizmann Institute, Israel Computational design of antibodies
09:40	Selected abstract: Jordan Dimitrov, INSERM, Paris, France Eccentric associations: interaction of antibodies with cofactors
10:00	Selected abstract: Mikhail Lebedin, MDC, Berlin, Germany Antibody diversification through non-VDJ insertions
10:15	Selected abstract: Christin Brueckner, FAU Erlangen-Nuremberg, Germany Investigating the mechanisms of IVIg mediated resolution of autoimmune inflammation
10:30	Coffee break
11:00	Andrea van Elsas, Aduro Biotech Europe, Oss, The Netherlands Cancer immunotherapy beyond PD1: novel immunomodulatory antibodies
11:40	Selected abstract: Aaron Meyer, UCLA, USA A Multivalent Binding Model Predicts FcγR Regulation and Effector Cell-Elicited Killing
12:00	Brandon de Kosky, Kansas University, USA Interpreting antibody sequence and function on a repertoire scale
12:40	Lunch and social time

Chairs

Suzan Rooijakkers, University Medical Center Utrecht, The Netherlands
Falk Nimmerjahn, FAU Erlangen-Nuremberg, Germany

18:00	David Humphreys, UCB Pharma, Slough, UK Studies with Fc-multimers: hexameric Fc and on-target hexameric IgG
18:40	Selected abstract: Simone Mader, LMU, Munich, Germany In utero exposure to anti-Aquaporin-4 antibodies alters brain vasculature und results in dysfunction of spatial cognitive function
19:10	Francesco Tedesco, Istituto Auxologico Italiano, Milan, Italy Alternative roles of C1q in cancer and tissue remodeling
20:00	Dinner
22:00	Social entertainment

Saturday, May 25, 2019

Departure

Confirmed Speakers

Doryen Bubeck, Imperial College, London, UK
Christian Busse, German Cancer Research Center, Heidelberg, Germany
Tineke Cantaert, Institut Pasteur, Phnom Penh, Cambodia
Michael Carroll, Harvard Medical School, Massachusetts, USA
Michel Cogné, University of Limoges, France
Davide Corti, VIR, Bellinzona, Switzerland
Brandon de Kosky, Kansas University, USA
Sarel J. Fleishman, Weizmann Institute, Israel
Piet Gros, University Utrecht, The Netherlands
Claudia Kemper, National Institutes of Health, Bethesda, USA
Florian Krammer, Icahn School of Medicine at Mount Sinai, New York, USA
Heidi Ling, Imperial College, London, UK
Brinda Prasad, Regeneron Pharmaceuticals, New York, USA
Daniel Ricklin, University Basel, Switzerland
Janine Schuurman, Genmab, Copenhagen, Denmark
Ron Taylor, University of Virginia, USA
Francesco Tedesco, University of Trieste, Italy
Marjolein van Egmond, VU University Medical Center Amsterdam, The Netherlands
Andrea van Elsas, Aduro Biotech Europe, Oss, The Netherlands
Taia Wang, Stanford University, USA

Registration

Registration deadline: April 22^nd, 2019

800 € - Scientist (single room)
700 € - Scientist (double room)
650 € - Student (double room, for single room register as scientist)
1000 € - Industry (single room)
320 € - Accompanying guest (no participation)

The registration fee includes:

5 nights at the Eden Roc Hotel (regardless of the registration status)
admission to all scientific sessions and poster exhibition
conference materials
internet access
breakfast, lunch, dinner, coffee breaks and refreshments
social entertainment

Please note accompanying persons are not eligible to participate at the conference.

Abstract Submission

Extended abstract deadline: April 19^th, 2019

We invite all registered participants to submit an abstract about their research. The scientific organizing committee will review all abstracts and select the most relevant contributions for short talks or poster presentation. Abstracts can only be submitted online via the "Register now" button.

Travel grants

Travel grant deadline: April 4^th, 2019

Several travel grants (€500-€650) will be awarded to selected students and postdocs. Selection will be performed by the conference organizers and session chairs.
One of our partners, The Antibody Society is offering up to 7 travel grants to both recognize the research activities of promising students / postdoctoral fellows and provide educational opportunities to them. In order to be considered for this competition, you must be a student or postdoc member of The Antibody Society. If you are not already a member, you may register here for a free student or postdoc membership.

Requirements:
1. submit an abstract
2. request financial support including a support letter from your mentor
3. register for free at The Antibody Society

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Organizers

Pierre Bruhns
Institut Pasteur, Paris, France

Falk Nimmerjahn
University of Erlangen-Nuernberg, Germany

Suzan H.M. Rooijakkers
University Medical Center Utrecht,
The Netherlands

Kathrin de la Rosa
Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Berlin, Germany

2018 edition – Abs & Complement

Contact:

Lien-Georgina Dettmann &
Timkehet Teffera
Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Berlin, Germany

antibodies@mdc-berlin.de