Chekulaeva Lab

We are focusing on understanding the molecular mechanisms that regulate intracellular RNA localization, translation, and stability and role of RNA-binding proteins and non-coding RNAs in this process.

Check Chekulaeva lab home page to learn about our research

September 27, 2021 in Nucleic Acids Res

Charcot-Marie-Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response

S. Mendonsa
N. von Kuegelgen
L. Bujanic
M. Chekulaeva

June 28, 2021 in Genome Biol

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

F. Witte
J. Ruiz-Orera
C. Ciolli Mattioli
S. Blachut
E. Adami
J.F. Schulz
V. Schneider-Lunitz
O. Hummel
G. Patone
M.B. Mücke
Jan Šilhavý
M. Heinig
L. Bottolo
D. Sanchis
M. Vingron
M. Chekulaeva
M. Pravenec
N. Hubner
S. van Heesch

April 01, 2021 in Cell Mol Life Sci

MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer

F. Imbastari
M. Dahlmann
A. Sporbert
C. Ciolli Mattioli
T. Mari
F. Scholz
L. Timm
S. Twamley
R. Migotti
W. Walther
G. Dittmar
A. Rehm
U. Stein

March 12, 2021 in Front Neurosci

Viruses and endogenous retroviruses as roots for neuroinflammation and neurodegenerative diseases

C. Römer

July 01, 2020 in Wiley Interdiscip Rev RNA

Conservation of a core neurite transcriptome across neuronal types and species

N. von Kügelgen
M. Chekulaeva

June 03, 2019 in Cold Spring Harb Perspect Biol

Roles of long noncoding RNAs and circular RNAs in translation

M. Chekulaeva
N. Rajewsky

June 01, 2019 in Methods

Genome-wide analysis of RNA and protein localization and local translation in mESC-derived neurons

K.A. Ludwik
N. von Kuegelgen
M. Chekulaeva

March 18, 2019 in Nucleic Acids Res

Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments

C. Ciolli Mattioli
A. Rom
V. Franke
K. Imami
G. Arrey
M. Terne
A. Woehler
A. Akalin
I. Ulitsky
M. Chekulaeva

September 19, 2017 in Nat Commun

RNA localization is a key determinant of neurite-enriched proteome

A. Zappulo
D. van den Bruck
C. Ciolli Mattioli
V. Franke
K. Imami
E. McShane
M. Moreno-Estelles
L. Calviello
A. Filipchyk
E. Peguero-Sanchez
T. Müller
A. Woehler
C. Birchmeier
E. Merino
N. Rajewsky
U. Ohler
E.O. Mazzoni
M. Selbach
A. Akalin
M. Chekulaeva

April 06, 2017 in Mol Cell

Translation of circRNAs

N.R. Pamudurti
O. Bartok
M. Jens
R. Ashwal-Fluss
C. Stottmeister
L. Ruhe
M. Hanan
E. Wyler
D. Perez-Hernandez
E. Ramberger
S. Shenzis
M. Samson
G. Dittmar
M. Landthaler
M. Chekulaeva
N. Rajewsky
S. Kadener

Institute & Campus November 29, 2017

A red thread in motor neuron disorders

Under a new grant from the EU, Marina Chekuleava of the MDC will lead a multinational consortium to find common mechanisms in diverse motor neuron diseases

Science October 26, 2017

The logistics of neuronal messenger RNAs

Where proteins are localized within a cell is crucial to their proper function, especially in cells like neurons. It affects neuronal development and even learning and memory. A research team led by Marina Chekulaeva has for the first time systematically analyzed how this localization comes about. Their article appeared in Nature Communications.

Science March 23, 2017

New study shows circular RNA can encode for proteins

A group of scientists in Israel and Germany, led by Prof. Sebastian Kadener from the Hebrew University of Jerusalem, have discovered a protein-encoding function for circular RNA. This kind of RNA molecule is highly active in brain cells and could play an important role in neurodegenerative diseases.