A glucose-containing ether lipid (Glc-PAF) as an antiproliferative analogue of the platelet-activating factor
Autor/innen
- M. Mickeleit
- T. Wieder
- M. Arnold
- C.C. Geilen
- J. Mulzer
- W. Reutter
Journal
- Angewandte Chemie International Edition
Quellenangabe
- Angew Chem Int Ed 37 (3): 351-353
Zusammenfassung
A new group of active substances, to which 1 belongs, inhibit cell proliferation and initiate programmed cell death (apoptosis) in keratinocytes. The glucosylated phospholipid 1 was synthesized from (S)-isopropylideneglycerol in nine steps with an overall yield of 25 %.