Identical lesion morphology in primary progressive and relapsing-remitting MS -an ultrahigh field MRI study


  • J. Kuchling
  • C. Ramien
  • I. Bozin
  • J. Dörr
  • L. Harms
  • B. Rosche
  • T. Niendorf
  • F. Paul
  • T. Sinnecker
  • J. Wuerfel


  • Multiple Sclerosis Journal


  • Mult Scler J 20 (14): 1866-1871


  • Potential differences between primary progressive (PP) and relapsing-remitting (RR) multiple sclerosis (MS) have been controversially discussed. In this study, we compared lesion morphology and distribution in patients with PPMS and RRMS (nine in each group) using 7 T MRI. We found that gray and white matter lesions in PPMS and RRMS patients did not differ in their respective morphological characteristics (e.g. perivascular p = 0.863, hypointense rim p = 0.796, cortical lesion count p = 0.436). Although limited by a small sample size, our study results suggest that PPMS and RRMS, despite differences in disease course and clinical characteristics, exhibit identical lesion morphology under ultrahigh field MRI.