Identical lesion morphology in primary progressive and relapsing-remitting MS -an ultrahigh field MRI study
Authors
- J. Kuchling
- C. Ramien
- I. Bozin
- J. Dörr
- L. Harms
- B. Rosche
- T. Niendorf
- F. Paul
- T. Sinnecker
- J. Wuerfel
Journal
- Multiple Sclerosis Journal
Citation
- Mult Scler J 20 (14): 1866-1871
Abstract
Potential differences between primary progressive (PP) and relapsing-remitting (RR) multiple sclerosis (MS) have been controversially discussed. In this study, we compared lesion morphology and distribution in patients with PPMS and RRMS (nine in each group) using 7 T MRI. We found that gray and white matter lesions in PPMS and RRMS patients did not differ in their respective morphological characteristics (e.g. perivascular p = 0.863, hypointense rim p = 0.796, cortical lesion count p = 0.436). Although limited by a small sample size, our study results suggest that PPMS and RRMS, despite differences in disease course and clinical characteristics, exhibit identical lesion morphology under ultrahigh field MRI.