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Wissenschaftliche Publikationen

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/ Bio-protocol

Expansion and precise CRISPR-Cas9 gene repair of autologous T memory stem cells from patients with T cell immunodeficiencies

  • X. Li
  • V.T. Chu
  • C. Kocks
  • K. Rajewsky
/ Leukemia

In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis

  • N.T. Tran
  • R. Graf
  • E. Acevedo-Ochoa
  • J. Trombke
  • T. Weber
  • T. Sommermann
  • C. Salomon
  • R. Kühn
  • K. Rajewsky
  • V.T. Chu
/ Sci Immunol

Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis

  • X. Li
  • T. Wirtz
  • T. Weber
  • M. Lebedin
  • E.D. Lowenstein
  • T. Sommermann
  • A. Zach
  • T. Yasuda
  • K. de la Rosa
  • V.T. Chu
  • J.H. Schulte
  • I. Müller
  • C. Kocks
  • K. Rajewsky
/ Bio-protocol

Application of a spacer-nick gene-targeting approach to repair disease-causing mutations with increased safety

  • N.T. Tran
  • M. Lebedin
  • E. Danner
  • R. Kühn
  • K. Rajewsky
  • V.T. Chu
/ Front Immunol

A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation

  • E. Xiong
  • O. Popp
  • C. Salomon
  • P. Mertins
  • C. Kocks
  • K. Rajewsky
  • V.T. Chu
/ Mol Ther Nucleic Acids

Efficient CRISPR/Cas9-mediated mutagenesis in primary human B cells for identifying plasma cell regulators

  • T.A. Le
  • V.T. Chu
  • A.C. Lino
  • E. Schrezenmeier
  • C. Kressler
  • D. Hamo
  • K. Rajewsky
  • T. Dörner
  • V.D. Dang
/ Sci Adv

Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells

  • N.T. Tran
  • E. Danner
  • X. Li
  • R. Graf
  • M. Lebedin
  • K. de la Rosa
  • R. Kühn
  • K. Rajewsky
  • V.T. Chu
/ Breast Cancer Res

Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors

  • G.J.J.E. Heynen
  • K. Lisek
  • R. Vogel
  • A. Wulf-Goldenberg
  • J. Alcaniz
  • E. Montaudon
  • E. Marangoni
  • W. Birchmeier
/ Cancer Res

YAP and β-catenin cooperate to drive oncogenesis in basal breast cancer

  • H.M. Quinn
  • R. Vogel
  • O. Popp
  • P. Mertins
  • L. Lan
  • C. Messerschmidt
  • A. Landshammer
  • K. Lisek
  • S. Château-Joubert
  • E. Marangoni
  • E. Koren
  • Y. Fuchs
  • W. Birchmeier
/ Mol Ther

CRISPR/Cas9-mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat severe congenital neutropenia

  • N.T. Tran
  • R. Graf
  • A. Wulf-Goldenberg
  • M. Stecklum
  • G. Strauß
  • R. Kühn
  • C. Kocks
  • K. Rajewsky
  • V.T. Chu