ANCA-assoziierte Vaskulitiden: Neuere Aspekte der Entstehung [Antineutrophil cytoplasmic antibody-associated vasculitis: novel aspects in the pathogenesis]
Authors
- A. Schreiber
- M. Choi
- R. Kettritz
Journal
- Nephrologe
Citation
- Nephrologe 7 (3): 192-199
Abstract
Antineutrophil cytoplasmic antibodies (ANCA) occur in patients with small vessel vasculitis and necrotizing crescentic glomerulonephritis. The main target antigens are proteinase 3 (PR3) and myeloperoxidase (MPO). Novel findings implicate lysosomal-associated membrane protein 2 (LAMP-2) as an additional antigen and epigenetic mechanisms as important transcriptional regulators for PR3 and MPO expression. Generation of ANCAs is a consequence of a complex interplay between antigen presentation, T-cells and B-cells. Recent data underline the significance of distinct CD4+T-cell subsets. A complementary PR3 protein has been identified which not only triggers the generation of anti-idiotypic antibodies recognizing PR3 but also constituents of the coagulation cascade. Additional important ANCA-induced neutrophil and monocyte effector functions were identified, such as the formation of DNA-containing neutrophil extracellular traps (NETs), the activation of a specific phosphatidylinositol-3 kinase isoform and the neutrophil serine protease-dependent IL-1{beta} generation. Animal models allow testing of treatment strategies which target these new molecules.