Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains
Authors
- A. Horatscheck
- S. Wagner
- J. Ortwein
- B.G. Kim
- M. Lisurek
- S. Beligny
- A. Schuetz
- J. Rademann
Journal
- Angewandte Chemie International Edition
Citation
- Angew Chem Int Ed 51 (37): 9441-9447
Abstract
A light switch for phosphotyrosine- recognizing proteins: Irradiation of the bioisosteric benzoylphosphonate suffices to "turn off" the activity of target proteins and to label them covalently. Photoactive bioisosters may find applications in functional cell biology, bioanalytics, and proteome research.