Der Riesenzelltumor des Knochens : Eine Analyse von 87 Patienten [Giant cell tumor of bone. An evaluation of 87 patients]


  • P.U. Tunn
  • P.M. Schlag


  • Zeitschrift fuer Orthopaedie und Ihre Grenzgebiete


  • Z Orthop Ihre Grenzgeb 141 (6): 690-698


  • Aim: Giant cell tumor (GCT) of bone is a very peculiar and interesting tumor due to of its biological behavior and the phenomenon of pulmonary metastases of a histologically benign tumor. We present the results of a retrospective study. Methods: Between 1965 and 2002 we treated 87 patients, 54 women and 33 men, for a GCT of bone. The average age of the patients was 28.2 (range 8 - 72) years. The median follow-up time was 91 months. 63 patients (72.4 %) were hospitalized with a primary tumor. Twelve of these patients (19 %) had a pathological fracture. 24 patients (27.6 %) presented with local recurrence. 7 tumors were malignant GCT of bone, 80 tumors were benign. According to the classification of Campanacci, 9 patients (10.3 %) were diagnosed in stage I, 42 (48.3 %) in stage II, and 36 (41.4 %) in stage III. Surgical procedures were intralesional curettage and packing with cement in 36 patients, and bone-grafting in 7. In 35 cases we performed a wide resection, and in nine an amputation. Results: Local recurrence was observed in 11 patients (12.6 %), all of them were benign GCT. Local recurrences were followed by an intralesional curettage and bone-grafting in three cases (42.8 %), packing with cement in seven (19.4 %). Three patients with local recurrence (27.3 %) also had synchronous pulmonary metastases. All patients diagnosed with benign GCT are still alive. 3 out of 7 patients with malignant GCT died from progression of metastatic disease. Conclusion: To reduce the risk of local recurrence and pulmonary metastases, we recommend an adjuvant therapy of GCT.