Endothelial cells don't waste: endothelial-derived lactate boosts muscle regeneration
Authors
- M. Castro
- J. Andrade
- M. Potente
Journal
- Developmental Cell
Citation
- Dev Cell 54 (2): 137-139
Abstract
Blood vessels are an essential interface between the circulation and tissue that deploy signaling molecules (angiocrines) for organ development, homeostasis, and repair. In a recent issue of Cell Metabolism, Zhang et al. (2020) identify lactate as an endothelial-derived signal promoting ischemic muscle regeneration, establishing metabolites as a new angiocrine class.