Mixed messages: re-initiation factors regulate translation of animal mRNAs
Authors
- B. Obermayer
- N. Rajewsky
Journal
- Cell Research
Citation
- Cell Res 24 (12): 1383-1384
Abstract
When ribosomes encounter upstream open reading frames (uORFs) during scanning of the 5' untranslated region (5' UTR), translation of the downstream ORF requires re-initiation. In a recent paper in Nature, Schleich et al. describe metazoan factors which specifically promote re-initiation.