Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils
Authors
- L. Cerofolini
- E. Ravera
- S. Bologna
- T. Wiglenda
- A. Böddrich
- B. Purfürst
- I. Benilova
- M. Korsak
- G. Gallo
- D. Rizzo
- L. Gonnelli
- M. Fragai
- B. De Strooper
- E.E. Wanker
- C. Luchinat
Journal
- Chemical Communications
Citation
- Chem Commun 56 (62): 8830-8833
Abstract
Recent structural studies show distinct morphologies for the fibrilsof Ab(1-42) and Ab(1-40), which are believed not to co-fibrillize.We describe here a novel, structurally-uniform 1 : 1 mixed fibrillarspecies, which differs from bothpure fibrils. It forms preferen-tially even when Ab(1-42) : Ab(1-40) peptides are mixed in a non-stoichiometric ratio.