Pharmacological fMRI - challenges in analysing drug-induced single-event BOLD responses
Authors
- A. Pohlmann
- H. Barjat
- L.C. Tilling
- M.F. James
Journal
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Citation
- Conf Proc IEEE Eng Med Biol Soc 2007: 3411-3416
Abstract
The interest in BOLD contrast based phMRI is likely to increase in the coming years, but detecting a direct modulation of regional brain activity by drugs presents a challenging problem. Based on in-vivo MRI and simulations we highlight some of the issues in detecting especially small BOLD signals in rat phMRI experiments.