- A. Pohlmann
- H. Barjat
- L.C. Tilling
- M.F. James
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society
- Conf Proc IEEE Eng Med Biol Soc 2007: 3411-3416
The interest in BOLD contrast based phMRI is likely to increase in the coming years, but detecting a direct modulation of regional brain activity by drugs presents a challenging problem. Based on in-vivo MRI and simulations we highlight some of the issues in detecting especially small BOLD signals in rat phMRI experiments.