Parallel analysis of gene activity of single cells in miniaturized formats

Genomics

Interim Heads: Tatiana Borodina (NGS Unit) & Thomas Conrad (Single Cell Technologies)

Profile

The main focus of the Scientific Genomics Platforms lies on functional genome research using sophisticated next generation sequencing methodologies as well as a variety of single cell applications.

The facility is located at the Berlin Institute for Medical System Biology in Mitte, Berlin. 

In the associated Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, we aim to explore fundamental biological phenomena and to pursue innovative approaches for translating new insights to eventually help the patient.

The Scientific Genomics Platforms invite all researchers from the MDC, Charité and elsewhere to collaborate on cutting-edge functional genomics-oriented projects. Therefore, we establish and develop procedures to provide access to newest technologies, particularly highly parallel sequencing. Moreover, the team supports collaborators in data analyses.

Current key activities of the platforms comprise basic research-oriented functional genomics research projects (e.g. RNA-based regulatory mechanisms and epigenetic phenomena), as well as medically relevant projects (e.g. decoding of genetic or gene-regulatory mechanisms with relevance in disease-associated processes, for example in cancer and metabolic diseases). Furthermore, we establish methods and provide services to cater large-scale projects in the field of gene panel, exome- or whole genome sequencing.

A particular focus of the Scientific Genomics Platforms consists of application of large-scale single-cell genomics analyses for which we have established unique, scalable technologies.

Team

The Genomics Unit comprises of two teams; the Next Generation Sequencing Core Facility and the Single Cell Technologies unit, under the management of Tatiana Borodina and Thomas Conrad, respectively.

Next Generation Sequencing Core Facility 

Facility Manager

 

Scientists
 
Technical Assistants 

 

 

Single Cell Technologies Unit

Facility Manager
 
Scientists
 
Research Assistant 

 

FACS Facility 

 

PhD Students

 

Technology Support

The Genomics platform offers diverse opportunities for collaborations in regards to your research project in the fields of functional genomics, commercial single-cell analysis, and advanced multi-omics approaches.

We are providing expertise and support for Next Generation Sequencing and Single-Cell Sequencing experiments under the management of Tatiana Borodina and Thomas Conrad, respectively.

If you are interested to discuss potential collaborations or you are in need of support for your sequencing experiment, please email Tatiana.Borodina@mdc-berlin.de or Thomas.Conrad@mdc-berlin.de directly.
 

Publications