Frederick W. Alt: Fundamental roles of chromatin loop extrusion in antibody diversification mechanisms

Prof. Dr. Frederick W. Alt (Boston Children's Hospital  | Harvard Medical School | Boston, USA)

Fred Alt has made seminal contributions to immunology, cancer biology and DNA repair. As a graduate student, he discovered a major form of genomic instability in cancer cells, gene amplification. Later on, his research on B cells provided key insights into how antibody diversity arises through VDJ recombination, somatic hypermutation and class switch recombination. Pioneering recent work, embedded into a vast range of other activities, follows up on these issues at the level of dynamic chromatin reorganization. You can read more about Fred Alt at: https://www.childrenshospital.org/research/researchers/frederick-alt

The event is hosted by Klaus Rajewsky (MDC), Fritz Melchers (DRFZ) and Andreas Radbruch (DRFZ)