Metabolic control of RNA splicing by polyamines
Authors
- Sebastian J. Hofer
- Ghada Alsaleh
- Anna Katharina Simon
Journal
- Trends in Biochemical Sciences
Citation
- Trends Biochem Sci
Abstract
Polyamines are ancient metabolites that support growth, translation, and autophagy. Zabala-Letona et al. reveal a new mode of action—‘metabolic shielding’—in which polyamines protect phosphorylation motifs in spliceosomal factors. This work links polyamines, for the first time, to alternative splicing, raising new questions for cancer, aging, and beyond.