Akutes pulmorenales Syndrom auf der Intensivstation: Rationale Diagnostik und Therapie [Acute pulmonary-renal syndrome in the intensive care unit: rational diagnostics and treatment]


  • P. Enghard
  • C. Erley
  • A. Schreiber


  • Nephrologe


  • Nephrologe 14: 438-445


  • Acute pulmonary-renal syndrome (PRS) is a combination of pulmonary hemorrhage and acute renal failure as the result of a mutual immunological origin. It is a life-threatening condition that often requires diagnostics and treatment in the intensive care unit. A potential PRS regularly presents intensive care physicians with various challenges, such as the question of how to differentiate infections from active PRS and how to treat critically ill patients with uncertain diagnoses. The most frequent cause of PRS is antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Less common causes include antiglomerular basement membrane (GBM) disease and systemic lupus erythematosus. In addition, the combination of acute pulmonary and renal failure is a frequent feature of many intensive care patients, making an acute PRS a frequent differential diagnosis. Taken together, PRS represents an important clinical syndrome and differential diagnosis in intensive care medicine.