The Sattentau lab is interested in understanding how lymphocytes interact with each other and with other immune cells during the processes of cell activation and cell death.
We are studying two related research areas.
- How dying lymphocytes are eliminated and recycled by scavenger cells called macrophages using a cell-eating process called “efferocytosis”. It is important to understand how efferocytosis works, because defects in efferocytosis result in inflammatory and degenerative conditions for which it will be important to develop therapeutic interventions.
- How the initiation and termination of lymphocyte activation is regulated. This is important as lymphocytes are central to our immune response against infections and cancer, and our ability to optimise lymphocyte activation may improve immunity.