Cell Biology

Cells continually renew themselves by “digesting” unused cellular material. This mechanism is called autophagy – an area in which immunologist Katja Simon has specialized. She has devised ways to use it to slow down the aging of immune cells.

The Max Delbrück Center wants to shape the future of medicine through innovation. But turning basic research into marketable products requires gaps to be bridged. This is achieved by the Technology Transfer Office – through funding schemes such as BOOST and Pre-GoBio. The winning projects for 2023 have now been selected.

It takes great patience and perseverance to turn research findings into new technologies or therapies. The Helmholtz Initiative and Networking Fund gives financial support to “pathfinder projects” that are particularly promising. Researchers at the Max Delbrück Center have now won grants for three projects.

Berlin-based research project MSTARS is entering its second round. Matthias Selbach and Fabian Coscia explain how the Max Delbrück Center is contributing, why the collaboration with Charité is so important, and how studying proteins in cells can help identify the best therapy for a patient.

Michael Potente wants to find out what makes blood vessels grow. For his work on the metabolic regulation of such growth, he has been selected as the recipient of the 2023 Judah Folkman Award from the North American Vascular Biology Organization.

HeLa contributed to more than 75,000 studies, some of them at the Max Delbrück Center. The cell culture line is indispensable to many biomedical laboratories. But who was the woman behind this abbreviation? During Black History Month we are celebrating her legacy—and our researchers say “Thank you!”

Dominik Müller investigates how lifestyle affects the molecular regulation processes in the body – such as how a high-sodium diet impacts the immune system and cardiovascular health. In doing so, he deliberately transcends the boundaries between disciplines.

Regulatory T cells ensure that immune responses happen in a controlled way. But eating too much salt weakens these cells’ energy supply, thus rendering them dysfunctional for a while. This may have implications for autoimmunity, an international team – including Dominik Müller – reports in “Cell Metabolism.”

Combining single-cell data with a self-learning algorithm reveals how structural changes in chromosomes can trigger cancer. This new method could pave the way for personalized cancer treatments, writes a team led by Ashley Sanders in “Nature Biotechnology”.

For nearly two decades, Oliver Daumke has been working to solve the mystery of how a molecular machine remodels cellular membranes. His team has now found the answer with the help of cryo-electron tomography. They report their findings in the journal “Nature Communications”.