Selbach Lab

Proteome Dynamics


Understanding how the genomic information is interpreted to yield a specific phenotype is perhaps the most important question in the post-genomic era.

Proteins are the central players in this process: First, they are the final product of most genes. Second, the function and dysfunction of proteins is directly responsible for phenotypes. Mass spectrometry-based proteomics is an extremely powerful and versatile approach to study proteome dynamics in biological systems. We are using quantitative mass spectrometry to study the dynamic proteome in health and disease.

Selected research examples




The lab is interested in two major questions. First, how is the genomic information processed to yield a specific proteome? Second, how do proteins that are expressed at a specific cellular condition affect the phenotype? In addition, as a technology-driven lab, we are also developing new methods.
1. From genes to proteins

We are investigating the principles of gene expression control that lead to a specific proteome. Here, we are specifically interested in studying protein synthesis and degradation and the relationship between mRNA and protein levels.

Selected examples

2. From proteins to phenotypes

To assess how the function and dysfunction of proteins affects phenotypes we are studying protein-protein interactions and post translational modifications.

Selected examples

3. Method development

As a technology-driven lab, we are also developing new methods to facilitate proteome analysis. Frequently, investigating key biomedical questions requires the development of new methods. Therefore, method development is an integral part of most projects, and most of the examples outlined above involve method development. In addition, we are also developing methods that are generally useful for the community

Selected examples


Research Topics