Research Highlights

Our research teams publish around 450 specialist articles every year. The MDC research highlights can be found here, presented in a comprehensible format.

Article

Science

Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy (ARVC)

Desmosomes are complex multiprotein structures of the cell membrane and provide structural and...
Science

The metastasis-associated gene S100A4 is a novel target of β-catenin/TCF signaling in colon cancer

Metastasis is the most relevant prognostic factor in cancer. S100A4 (metastasin) is one of the genes...
Science

Natural Selection on Human MicroRNA Binding Sites Inferred from Single Nucleotide Polymorphism Data

By combining SNP data with population genetics, MDC’s bioinformatics and systems biology expert...
garratt1
Science

Control of Peripheral Nerve Myelination by the β-Secretase BACE1

The protease BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) is essential for the...
Science

Hematopoietic stem cell and multi lineage defects generated by constitutive β -catenin activation.

The continuous regeneration of blood cells depends on the unique ability of few hematopoietic stem...
Science

The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic b-cellsand intestinal endocrine cells

Endocrine cells in the pancreas and intestine play key roles in nutritional homeostasis through the...
Science

A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery

A quality control system surveys the lumen of the endoplasmic reticulum (ER) for terminally...
Science

M-line deficient titin causes cardiac lethality through impaired maturation of the sarcomere

Titin is a giant muscle protein that forms a continuous filament system in both skeletal and cardiac...
Science

An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis

Arginine/lysine-rich motifs typically function as targeting signals for the translocation of...
Science

The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment

A specialized quality control system samples the endoplasmic reticulum (ER) for proteins that...