Complex diseases are often characterized by an accumulation of multiple perturbations, such as mutations or over-expression of proteins, in rather large and complex cellular networks. The consequences of these perturbations can hardly be analyzed by pure reasoning.
Here, mathematical modelling contributes to a deeper understanding of the regulatory systems and provides thus a better basis for the interpretation of high-throughput data and identification of effective drug targets.
Main projects in the last years have focused on signal transduction, in particular on the NF-κB/IKK pathway and the Wnt/β-catenin pathway. In many of our projects we closely collaborate with experimental partners in and outside of the MDC.
- Antonio Politi, Postdoc, went to EMBL Heidelberg
- Jana Schütze, PhD student, went to Humboldt-University Berlin
- Christian Brettschneider, Postdoc, went to Atos Consulting
- Alexandra Iovkova, scientist, went to TU Munich
- Dorothea Busse, Postdoc, went to IRI LifeSciences, Humboldt-University Berlin
- Bente Kofahl, Postdoc, went to Freiburg University
- Laura Stumpf, Master student, went to Insilico Biotechnology
Guests and internships
- Niklas Hartung, guest PhD student
- Kristin Meisel, internship 2011
- Dominik Otto, internship 2014
- Luis Martini, internship 2015
- Maria Trofimova, internship 2016
- Pia Brechmann, internship 2016
- Mirjam van Bentum, Charité MoIMed rotation student 2016