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Wolf Lab

Mathematical Modelling of Cellular Processes

Profile

Our group develops and analyses mathematical models of signaling pathways and gene-regulatory networks in normal and disease states. We focus on processes in cancer biology and early development as well as design principles of biological networks.

Complex diseases are often characterized by an accumulation of multiple perturbations, such as mutations or over-expression of proteins, in rather large and complex cellular networks. The consequences of these perturbations can hardly be analyzed by pure reasoning.

Here, mathematical modelling and computational analyses contribute to a deeper understanding of the regulatory systems. They provide a rational basis for the interpretation and integration of multi-omics or high-throughput data and identification of effective drug targets paving the way for a patient-specific understanding of diseases.

In the last years, we analysed gene expression and signal transduction, in particular the NF-κB/IKK, p53, Wnt/β-catenin and Hes1 pathways that are crucial for cell fate decisions. Moreover, we studied the effect of oncogenes in cellular metabolism. In many of our projects we closely collaborate with experimental and clinical partners in and outside of the MDC.

Team

Publications

News

Former lab members

  • Katharina Baum, PhD student and Postdoc, went to Hasso-Plattner-Institute, Potsdam
  • Uwe Benary, PhD student and Postdoc, went to Omikron Data Quality GmbH
  • Janina Mothes, PhD student and Postdoc, went to Bayer AG
  • Laura Stumpf, Master student, went to Insilico Biotechnology
  • Bente Kofahl, PhD student and Postdoc, went to Freiburg University  
  • Dorothea Busse, Postdoc, went to IRI LifeSciences, Humboldt-University Berlin
  • Alexandra Iovkova, scientist, went to TU Munich
  • Christian Brettschneider, Postdoc, went to Atos Consulting
  • Jana Schütze, PhD student, went to Humboldt-University Berlin
  • Antonio Politi, Postdoc, went to EMBL Heidelberg

Guests and internships

  • Lucas Arnoldt, internship 2020
  • Florian Auer, internship 2020
  • Jonathan Grill, Bachelor student 2018/2019 
  • Sandra Krüger, internship 2018 
  • Janosch Brandhorst, Bachelor student 2017/2018
  • Mirjam van Bentum, Charité MoIMed rotation student 2016
  • Pia Brechmann, internship 2016
  • Maria Trofimova, internship 2016
  • Luis Martini, internship 2015
  • Dominik Otto, internship 2014
  • Kristin Meisel, internship 2011
  • Niklas Hartung, guest PhD student
Prof. Dr. Jana Wolf
Prof. Dr. Jana Wolf
Contact
Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Robert-Rössle-Straße 10
13125 Berlin, Deutschland
Building 31.1, Room 5016