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J. Wolf Lab

Mathematical Modelling of Cellular Processes


Our group develops and analyses mathematical models of signaling pathways and gene-regulatory networks in normal and disease states. We focus on processes in cancer biology and early development as well as design principles of biological networks.

Complex diseases are often characterized by an accumulation of multiple perturbations, such as mutations or over-expression of proteins, in rather large and complex cellular networks. The consequences of these perturbations can hardly be analyzed by pure reasoning.

Here, mathematical modelling and computational analyses contribute to a deeper understanding of the regulatory systems. They provide a rational basis for the interpretation and integration of multi-omics or high-throughput data and identification of effective drug targets paving the way for a patient-specific understanding of diseases.

In the last years, we analysed gene expression and signal transduction, in particular the NF-κB/IKK, p53, Wnt/β-catenin and Hes1 pathways that are crucial for cell fate decisions. Moreover, we studied the effect of oncogenes in cellular metabolism. In many of our projects we closely collaborate with experimental and clinical partners in and outside of the MDC.




Former lab members

  • Leonie Lorenz, Master student, went to EMBL-EBI
  • Ziyue Chen, Master student
  • Daria Komkova, Master student
  • Katharina Baum, PhD student and Postdoc, went to Hasso-Plattner-Institute, Potsdam
  • Uwe Benary, PhD student and Postdoc, went to Omikron Data Quality GmbH
  • Janina Mothes, PhD student and Postdoc, went to Bayer AG
  • Laura Stumpf, Master student, went to Insilico Biotechnology
  • Bente Kofahl, PhD student and Postdoc, went to Freiburg University  
  • Dorothea Busse, Postdoc, went to IRI LifeSciences, Humboldt-University Berlin
  • Alexandra Iovkova, scientist, went to TU Munich
  • Christian Brettschneider, Postdoc, went to Atos Consulting
  • Jana Schütze, PhD student, went to Humboldt-University Berlin
  • Antonio Politi, Postdoc, went to EMBL Heidelberg

Guests and internships

  • Yukino Fujiya, internship 2023
  • Leonie Lorenz, internship 2021
  • Ziyue Chen, internship 2020/2021
  • Daria Komkova, internship 2021
  • Bashar Morouj, Student research assistant, 2021
  • Lucas Arnoldt, internship 2020
  • Florian Auer, internship 2020
  • Jonathan Grill, Bachelor student 2018/2019 
  • Sandra Krüger, internship 2018 
  • Janosch Brandhorst, Bachelor student 2017/2018
  • Mirjam van Bentum, Charité MoIMed rotation student 2016
  • Pia Brechmann, internship 2016
  • Maria Trofimova, internship 2016
  • Luis Martini, internship 2015
  • Dominik Otto, internship 2014
  • Kristin Meisel, internship 2011
  • Niklas Hartung, guest PhD student

Join us

We always welcome applications from motivated individuals for internships or positions as a Master student, PhD student or PostDoc. Ideally, applicants already have a background in the field of biology as well as computer science/modeling.

If you are interested in joining our lab, please contact our secretary Constanze Dahl ( and include the following documents in your application: CV, relevant certificates/ university transcripts (listing the courses and grades), a short text describing why you are interested in joining our lab (email text is fine), when you would like to start (for interns: how long you would like to join us).