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Wolf Lab

Mathematical Modelling of Cellular Processes

Profile

Our group develops and analyses mathematical models of mammalian signaling pathways and gene-regulatory networks in normal and disease states. For our investigations we use tools such as simulations, bifurcation analyses and sensitivity analyses.

Complex diseases are often characterized by an accumulation of multiple perturbations, such as mutations or over-expression of proteins, in rather large and complex cellular networks. The consequences of these perturbations can hardly be analyzed by pure reasoning.

Here, mathematical modelling contributes to a deeper understanding of the regulatory systems and provides thus a better basis for the interpretation of high-throughput data and identification of effective drug targets. 

Main projects in the last years have focused on signal transduction, in particular on the NF-κB/IKK pathway and the Wnt/β-catenin pathway. In many of our projects we closely collaborate with experimental partners in and outside of the MDC.

Team

Publications

Former lab members

  • Antonio Politi, Postdoc, went to EMBL Heidelberg
  • Jana Schütze, PhD student, went to Humboldt-University Berlin
  • Christian Brettschneider, Postdoc, went to Atos Consulting
  • Alexandra Iovkova, scientist, went to TU Munich
  • Dorothea Busse, Postdoc, went to IRI LifeSciences, Humboldt-University Berlin
  • Bente Kofahl, Postdoc, went to Freiburg University
  • Laura Stumpf, Master student, went to Insilico Biotechnology

Guests and internships

  • Niklas Hartung, guest PhD student
  • Kristin Meisel, internship 2011
  • Dominik Otto, internship 2014
  • Luis Martini, internship 2015
  • Maria Trofimova, internship 2016
  • Pia Brechmann, internship 2016
  • Mirjam van Bentum, Charité MoIMed rotation student 2016
Dr. Jana Wolf
Dr. Jana Wolf
Contact
Phone: 9406-2641
Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Robert-Rössle-Str. 10
13092 Berlin, Deutschland
Building 31.1, Room 5016