Computational Biology

Data Science, the extraction of relevant insights from data, has firmly positioned itself at the forefront of health and life science research. Machine Learning and Deep Learning are foreseen to become key disruptive technologies within Data Science in translational research and personalized medicine applications. The cross-cutting focus area Data Science and Artificial Intelligence comprises research groups spanning MDC’s different research areas:

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Wissenschaftliches Bild
Press Release No. 21 Berlin

Uncovering hidden gene switches

The Ohler lab has developed a new method called TESLA-seq to identify regulatory regions in the human genome. The research was published in “Cell Genomics.”
Lachender Mann hält eine weiße, gelochte 3D-gedruckte Kugel in der Hand.
Science

The modeler of cell development

As embryos develop, countless molecular mechanisms interact in intricate ways. Markus Mittnenzweig builds computational models to help decipher and predict the complex processes behind cell differentiation and tissue formation. His work could also contribute to preventing disease.
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Science

HAICORE: More than just computing power

Providing computing resources for scientific research – that’s the mission of Helmholtz AI Compute Resources, a Helmholtz Association initiative. The Max Delbrück Center has now joined the Karlsruhe Institute of Technology and Forschungszentrum Jülich in hosting the program.
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Press Release No. 11 Berlin

Joint Berlin Data & AI Center planned

Data-driven research is crucial for tackling societal challenges. In a collaboration that is so far unique, Berlin's Universities of Excellence, the Max Delbrück Center, and the Helmholtz-Zentrum Berlin, together with the Zuse Institute Berlin, aim to establish a powerful Data and AI Center.
3D molecular reconstruction of a lung tumor
Press Release No. 7 Berlin

Towards understanding tumors in 3D

Researchers in Nikolaus Rajewsky’s lab at Max Delbrück Center combined high-resolution, single-cell spatial technologies to map a tumor’s cellular neighborhoods in 3D and identify potential targets for personalized cancer therapy. They describe their findings in two separate papers in “Cell Systems.”
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Press Release No. 5 Berlin

Inflammatory messenger fuels Alzheimer’s

Researchers from Charité – Universitätsmedizin Berlin and the Max Delbrück Center have detailed the precise mechanism through which the inflammatory signaling molecule IL-12 contributes to Alzheimer’s disease. The study was published in the journal “Nature Aging.”
Jakob Metzger
Science

The juggler of numbers

Jakob Metzger has developed a new generation of brain organoids that are easier to mass-produce and uniform. The data they provide on rare neurological diseases can speed up the time it takes to find new therapies.
2D map of gene expression in the metastatic lymph node
Press Release No. 15 Berlin

3D maps of diseased tissues at subcellular precision

An open-source platform developed by researchers in Nikolaus Rajewsky’s lab at the Max Delbrück Center creates molecular maps from patient tissue samples with subcellular precision, enabling detailed study and potentially enhancing routine clinical pathology. The study was published in “Cell.”
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Institute & Campus

No research without IT girls

Life sciences research generates enourmous amounts of data; their analysis is thus no longer possible without machine learning or artificial intelligence. On Girls' Day, students from grades 6 to 12 found out what female mathematicians and computer scientists do at the Max Delbrück Center.
Prof. Jens Reich – Bundesverdienstorden
Institute & Campus

Don’t retreat to splendid isolation

He is a molecular biologist and physician, a GDR civil rights activist and bioethicist, a person with integrity and a sense of community. Until 2022, he was an ombudsman at the Max Delbrück Center. We celebrate the 85th birthday of Professor Jens Reich.