C. Birchmeier Lab | Max Delbrück Center for Molecular Medicine

Our lab focuses on functional analysis of genes important in development and stem cells, concentrating on muscle, the nervous system and endocrine organs.

We observe that many genes control both, developmental and regenerative processes in the adult. For our work, we use mouse genetics and stem cells culture, and define molecular mechanisms by genomic and proteomic technologies.

Group Leader

Prof. Dr. Carmen Birchmeier-Kohler

Prof. Dr. Carmen Birchmeier-Kohler

cbirch@mdc-berlin.de

	tel: +49 30 9406 - extension	email (append @mdc-berlin.de)
Group Leader
Prof. Dr. Carmen Birchmeier	-3313	cbirch
Assistant
Dr. Timkehet Teffera	-3313	timkehet.teffera
Senior Scientist
Dr. Thomas Müller	-2842	thomu
Postdoctoral Fellows
Dr. Minchul Kim	-2864, -3701	minchul.kim
Dr. Ines Lahmann	-2864, -3701	ines.lahmann
Dr. Pierre-Louis Ruffault	-2864, -3359	pierre-louis.ruffault
Dr. Kun Song	-2772, -3359	kun.song
PhD Students
Elias Lowenstein	-3772, -3701	elijahdavid.lowenstein
Yao Zhang	-3848, -3701	yao.zhang
Undergraduate Students and Interns

Technicians
Bettina Brandt	-2257	bettina.brandt
Sven Buchert	-3359	sbuchert
Carola Griffel	-2257	cgriffel
Vivian Schulz (parental leave)	-2257	vivian.schulz
Animal Caretakers
Claudia Päseler	-4886	claudia.paeseler
Petra Stallerow	-4886	petra.stallerow

The lab is focused on the functional analysis of genes important in embryonic development and adult stem cells, concentrating on muscle, the nervous system and endocrine cells.

For our work, we use mouse genetics and cell culture analysis of stem cells, and define molecular mechanisms using genome and proteome technologies.

Nervous System Development

Specification of Neuronal Cell Types

Muscle Development

The genetic hierarchy that controls muscle development and repair

March 18, 2019 in Nucleic Acids Res

Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments

C. Ciolli Mattioli et al.

March 12, 2019 in Genes Dev

Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells

I. Lahmann et al.

December 18, 2018 in Proc Natl Acad Sci USA

Mutation in LBX1/Lbx1 precludes transcription factor cooperativity and causes congenital hypoventilation in humans and mice

L.R. Hernandez-Miranda et al.

December 01, 2018 in Diabetes

Haploinsufficiency of Insm1 impairs postnatal baseline β-cell mass

September 20, 2018 in Cell

Mutations in disordered regions can cause disease by creating dileucine motifs

K. Meyer et al.

September 12, 2018 in Nat Rev Drug Discov

Defining orphan conditions in the context of the European orphan regulation: challenges and evolution

D.J. O'Connor et al.

September 03, 2018 in EMBO J

Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons

T. Müller et al.

May 10, 2018 in Genes Dev

Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells

April 15, 2018 in Hum Mol Genet

Predominant patterns of splicing evolution on human, chimpanzee, and macaque evolutionary lineages

J. Xiong et al.

March 01, 2018 in Drug Discov Today

Establishing rarity in the context of orphan medicinal product designation in the European Union

S. Tsigkos et al.

Skelettmuskulatur

Press Release No. 9 March 13, 2019 Berlin

Oscillation in muscle tissue

When a muscle grows or a muscle injury heals, some of the stem cells develop into new muscle cells. A research team at the MDC led by Carmen Birchmeier has now described in the journal Genes and Development how this process is regulated by two proteins produced in an oscillatory manner.

Green sponge-like network of mouse skeletal muscle

Science June 07, 2018 By Dr. Martin Ballaschk

Muscle research moves from the Petri dish to gene therapy

The conference “Muscle Development, Regeneration and Disease 2018” took place at the MDC in late April. This event has in recent years become an increasingly important international platform for muscle research.

Press Release No. 16 July 26, 2017 Berlin

How mice babies ensure mother’s protection

Almost immediately after birth, mouse pups that are separated from their mother are able to make...

Science January 30, 2015 By Russell Hodge

A cool new method for growing better muscle

Striated muscle , which allows us to consciously move our bodies and makes up tissues such as the...

Science May 23, 2014 By Russell Hodge

How to insulate a stripped nerve

Without a sheath called myelin , electrical impulses would travel through our nervous system along...

Science March 01, 2012 By Russell Hodge

"I'm picking up good vibrations"

If you're reading this on your laptop right now, say over a Venti Latté at Starbucks, take your hand...

Science March 21, 2007 By Russell Hodge

Keeping muscle cells on hold

Many of our body’s tissues carry out self-repair by calling up stem cells, which specialize to...

Research Topics