Force Gated Ion Channels
Dear Colleagues and Friends,
This meeting will cover the latest findings in the field of Force Gated Ion Channels. The meeting will cover the role of these mechanically-gated channels in hearing, touch, pain, proprioception, vascular remodeling, bone growth and osmosensation. Participants will hear the latest research on how these channels function and shed light on the molecules that build these channels, convey energy to them and interact with them.
The conference will bring together internationally recognized leaders in their fields and is aimed at fostering scientific exchange between participants as well as supporting young and emerging scientists by providing the opportunity for them to present their newest and most exciting data in a short talk format.
We warmly invite you to join us in Berlin and look forward to your participation.
Miriam Goodman, Martin Göpfert, Lily Jan, Gary Lewin and Kate Poole
Confirmed Speakers
- Corey, David, Harvard University
- Goodman, Miriam, Stanford University
- Göpfert, Martin, University of Göttingen
- Lewin, Gary, MDC Berlin
- Müller, Ulrich, Johns Hopkins Baltimore
- Jan, Yuh Nung, UCSF
- Patapoutian, Ardem, HHMI Scripps Research Institute
- Poole, Kate, University of New South Wales, Sydney Australia
Poster Presentation Guidelines
The posters will be mounted on movable walls on stands provided by the organizers in the Max Delbrück Communications Center.
Poster Size: Portrait formatted posters in DIN A0 size (118.9 cm x 84.1 cm) are recommended. The size of your printed poster should not exceed 120 cm in height and 95 cm in width.
Posters Hanging: on the evening or morning before the session, but may be set up 1 hour latest, before the start of the session.
Posters have to be printed on paper. Affix your poster on the poster panel marked with your number. Further assistance and adhesive material will be available at the registration' near the poster exhibition space. Affix your poster on the poster panel marked with your number. Please only use the provided adhesive material!
Venue
MDC.C Axon 1+2
Time
Catering
Coffee and Cake; Buffet
Deadline Abstract submission
September 24th, 2018
Hashtag
#forcechannels
Program
Program and list of posters (PDF)
- Wednesday, October 17, 2018
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Französiche Friedrichstadtkirche, Gendarmenmarkt 5, 10117 Berlin, Germany
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Opening remarks
18:00 Introduction: Miriam Goodman
18:10 Welcome Lecture: Robert Fettiplace, Kavli Prize Winner 2018
19:10 Reception
- Thursday, October 18, 2018
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Max Delbrück Communications Center – MDC.C (House 83), Robert-Rössle-Straße 10, 13125 Berlin, Germany, Axon 1
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08:00 Registration
Session 1 | Chair: Gary Lewin
09:00 Martin Göpfert, University of Göttingen
Mechanosensitive channels for gravity sensing and hearing in flies09:25 Lightning talk, Jan Clemens, European Neuroscience Institute
Mean and Variance adaptation in the Drosophila Ear09:30 Reza Sharif Naeini, McGill University
TACAN is an Ion Channel Involved in Noxious Mechanosensation09:55 Lightning talk: Kara Marshall, Scripps Research Institute
Molecular Mechanisms of Stomach Stretch Sensing10:00 Kristian Franze, University of Cambridge
The role of mechanosensitive ion channels in vertebrate development10:25 Lightning talk: Nicole Scholz, Rudolf-Schönheimer-Institute of Biochemistry
GPCR-dependent modulation of ion channels10:30 Coffee Break
11:00 Slav Bagriantsev, Yale University
Mechano-gated ion channels in somatosensory neurons of tactile specialist birds (tent)11:25 Lightning talk: Yiquan Tang, MRC Laboratory of Molecular Biology
The evolutionarily conserved TMC-CIB channel complexes function as mechanosensors in Caenorhabditis elegans and mouse11:30 Laura Bianchi, University of Miami
Glial regulators of ionic homeostasis control mechanosensation in C. elegans11:55 Lightning talk: Fabian Passini, Department of Health Sciences and Technology - ETH Zurich
PIEZO1 Senses Mechanical Loading and Induces Nanomolar Calcium Signals in Tendon Cells12:00 Jörg Grandl, Duke University Medical Center
Transduction of Mechanical Stimuli by Piezo Ion Channels12:30 Lunch and Poster Session
Session 2 | Chair: Martin Göpfert
14:00 Miriam Goodman, Stanford University
C.elegans sensory channels14:25 Lightning talk: Anthony Peng, University of Colorado Anschutz
Is climbing and slipping the true model for myosin motor adaptation in mammalian hair cells?14:30 David Corey, Harvard University:
The mammalian hair cell channel14:55 Jeffrey Holt, Harvard University
The hair cell mechanotransduction channel15:20 Lightning talk: Eric Mulhall, Harvard Medical School
The Dynamic Strength of the Tip-Link Bond in Hair Cells15:25 Lightning talk: Philip Hehlert, Schwann-Schleiden Research Center
Mechano-gating properties of Drosophila NOMPC15:30 Thomas Jentsch, Leibniz Institute for Molecular Pharmacology
Properties and roles of volume-regulated LRRC8/VRAC anion channels15:55 Ulrich Müller, Johns Hopkins Baltimore
New molecular players in hair cell mechanotransduction16:20 Lightning talk: Lightning talk: Frederick Schwaller, Max Delbrück Center for Molecular Medicine
Ush2A is a vibration sensor involved in touch16:25 Elizabeth Haswell, Washington University
Mechanosensitive Ion Channels in Green Organisms16:50 Lightning talk: Ivan Radin, Washington University, St. Louis
Evolution and adaptation of Piezo proteins in the green lineage16:55 Lightning talk: Manuela Schmidt, MPI of Experimental Medicine
Regulation of Piezo2 function – novel insights from its interactome17:05 Poster Session
19:05 Free evening
- Friday, October 19, 2018
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Max Delbrück Communications Center – MDC.C (House 83), Robert-Rössle-Straße 10, 13125 Berlin, Germany, Axon 1
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Session 3 | Kate Poole
09:00 Paul Heppenstall, EMBL Monterotondo
Manipulating sensory transduction with genetic tools in mice09:25 Lightning talk: Shefin George, Stanford University
Membrane lipid properties modulate hair cell mechanotransduction09:30 Kate Poole, University of New South Wales
Chondrocyte mechanotransduction09:55 Lightning talk: Lightning talk: Michael Dudek, University of Manchester
The Trpv4 channel is involved in setting the pace of the circadian clock in cartilage and intervertebral discs10:00 Anthony Ricci, Stanford University
The emerging role of the lipid bilayer in regulating hair cell mechanotransduction10:25 Lightning talk: Lightning talk: Chonglin Guan, Georg August University of Goettingen
Myosin–dependent mechanosensory adaptation in Drosophila10:30 Coffee Break
11:00 Eric Honore, CNRS Nice
Piezos roles in regulating vascular tone11:25 Lightning talk: Zhongjie Ye, Scuola Internazionale Superiore di Studi Avanzati
Unfolding of mechanosensitive channels Piezo1 and Piezo211:30 Valeria Vásquez, University of Tennessee
Fine-tuning ion channel gating with dietary fatty acids11:55 Lightning talk: Sylvia Fechner, Stanford University, School of Medicine
Composition of native met channels responsible for gentle touch sensation12:00 Medha Pathak, University of California, Irvine
Piezo1 activation gains traction12:25 Lightning talk: Angela Schlegel, Washington University, Saint Louis
Channel Behavior of the Mechanosensitive Ion Channel MscS-Like 1 is Modulated by Charged Pore-Lining and Soluble Domain Cys Residues12:30 Lunch and Poster Session
Session 4 | Chair: Lily Jan
14:30 Gary Lewin, MDC Berlin
Tethers in sensory transduction: man and mouse14:55 Lightning talk: Johannes Elferich, Oregon Health and Science University
Structure of the PCDH15/LHFPL5 complex at the lower insertion point of the mammalian hair cell tip link15:00 Steve Brohawn, University of California, Berkeley
Mechanosensitive Potassium Channel Structure and Function15:25 Lightning talk: Jerome Lacroix, Western University of Health Sciences
Identification of the Binding Site of a Piezo1-Selective Small Molecule Agonist15:30 Coffee Break
16:00 Merritt Maduke, Stanford University
Mechanosensitive channels in ultrasonic neuromodulation16:25 Lightning talk: Christopher Cunningham, Johns Hopkins University
Transmembrane-O-methyltransferase (TOMT) regulates localization of TMC proteins to stereocilia in cochlear hair cells16:30 Ardem Patapoutian, HHMI Scripps Research Institute
Piezo ion channel structure and function16:55 Lightning talk: Daniel Tracey; Indiana University
Proprioceptive neurons in larvae of Drosophila melanogaster show direction selective responses that require the mechanosensory channel TMC - Saturday, October 20, 2018
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Max Delbrück Communications Center – MDC.C (House 83), Robert-Rössle-Straße 10, 13125 Berlin, Germany, Axon 1
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Session 5 | Chair: Miriam Goodman
09:30 Boris Martinac, University of New South Wales
Bacterial mechanotransduction channels09:55 Lightning talk: Allen Liu, University of Michigan
Mechanogenetics: Repurposing bacterial mechanosensitive channel MscL in mammalian cells10:00 Carsten Grashoff, MPI for Biochemistry
Piconewton-sensitive biosensors to investigate molecular forces in cells10:25 Lightning talk: Allen Liu, University of Michigan
Mechanogenetics: Repurposing bacterial mechanosensitive channel MscL in mammalian cells10:30 Coffee Break
11:00 Yuh Nung Jan, University of California, San Francisco
Structure of drosophila mechanotransduction TRP channels11:25 Lightning talk: Oscar Sanchez Carranza, Max Delbrück Center for Molecular Medicine
Voltage-gating of mechanosensitive Piezo channels11:30 Bailong Xiao, School of Pharmaceutical Sciences, Tsinghua University
Structure and function of PIEZO proteins11:55 Lightning talk: Anders Enjin, Lund University
Humidity sensing in insects12:00 Lunch and Poster Session
14:00 Stefan Lechner, University of Heidelberg
Sensory transduction regulation14:25 Closing remarks, Farewell
15:00 End of Conference
Organizers
Prof. Gary Lewin