Force-gated channels, physiology, regulation, and function

Force Gated Ion Channels

Dear Colleagues and Friends,

This meeting will cover the latest findings in the field of Force Gated Ion Channels. The meeting will cover the role of these mechanically-gated channels in hearing, touch, pain, proprioception, vascular remodeling, bone growth and osmosensation. Participants will hear the latest research on how these channels function and shed light on the molecules that build these channels, convey energy to them and interact with them.

The conference will bring together internationally recognized leaders in their fields and is aimed at fostering scientific exchange between participants as well as supporting young and emerging scientists by providing the opportunity for them to present their newest and most exciting data in a short talk format.
We warmly invite you to join us in Berlin and look forward to your participation.

Miriam Goodman, Martin Göpfert, Lily Jan, Gary Lewin and Kate Poole

Confirmed Speakers

  • Corey, David, Harvard University
  • Goodman, Miriam, Stanford University
  • Göpfert, Martin, University of Göttingen
  • Lewin, Gary, MDC Berlin
  • Müller, Ulrich, Johns Hopkins Baltimore
  • Jan, Yuh Nung, UCSF
  • Patapoutian, Ardem, HHMI Scripps Research Institute
  • Poole, Kate, University of New South Wales, Sydney Australia

Poster Presentation Guidelines

The posters will be mounted on movable walls on stands provided by the organizers in the Max Delbrück Communications Center.

Poster Size: Portrait formatted posters in DIN A0 size (118.9 cm x 84.1 cm) are recommended. The size of your printed poster should not exceed 120 cm in height and 95 cm in width.

Posters Hanging: on the evening or morning before the session, but may be set up 1 hour latest, before the start of the session.

Posters have to be printed on paper. Affix your poster on the poster panel marked with your number. Further assistance and adhesive material will be available at the registration' near the poster exhibition space. Affix your poster on the poster panel marked with your number. Please only use the provided adhesive material! 


Robert-Rössle-Str. 10
Max Delbrück Communications Center
13125 Berlin




Coffee and Cake; Buffet


Deadline Abstract submission

September 24th, 2018






Program and list of posters (PDF)

Wednesday, October 17, 2018

Französiche Friedrichstadtkirche, Gendarmenmarkt 5, 10117 Berlin, Germany

Opening remarks

18:00 Introduction: Miriam Goodman

18:10 Welcome Lecture: Robert Fettiplace, Kavli Prize Winner 2018

19:10 Reception

Thursday, October 18, 2018

Max Delbrück Communications Center – MDC.C (House 83), Robert-Rössle-Straße 10, 13125 Berlin, Germany, Axon 1

08:00 Registration

Session 1 | Chair: Gary Lewin

09:00 Martin Göpfert, University of Göttingen
Mechanosensitive channels for gravity sensing and hearing in flies

09:25 Lightning talk, Jan Clemens, European Neuroscience Institute
Mean and Variance adaptation in the Drosophila Ear

09:30 Reza Sharif Naeini, McGill University
TACAN is an Ion Channel Involved in Noxious Mechanosensation

09:55 Lightning talk: Kara Marshall, Scripps Research Institute
Molecular Mechanisms of Stomach Stretch Sensing

10:00 Kristian Franze, University of Cambridge
The role of mechanosensitive ion channels in vertebrate development

10:25 Lightning talk: Nicole Scholz, Rudolf-Schönheimer-Institute of Biochemistry
GPCR-dependent modulation of ion channels

10:30 Coffee Break

11:00 Slav Bagriantsev, Yale University
Mechano-gated ion channels in somatosensory neurons of tactile specialist birds (tent)

11:25 Lightning talk: Yiquan Tang, MRC Laboratory of Molecular Biology
The evolutionarily conserved TMC-CIB channel complexes function as mechanosensors in Caenorhabditis elegans and mouse

11:30 Laura Bianchi, University of Miami
Glial regulators of ionic homeostasis control mechanosensation in C. elegans

11:55 Lightning talk: Fabian Passini, Department of Health Sciences and Technology - ETH Zurich
PIEZO1 Senses Mechanical Loading and Induces Nanomolar Calcium Signals in Tendon Cells

12:00 Jörg Grandl, Duke University Medical Center
Transduction of Mechanical Stimuli by Piezo Ion Channels

12:30 Lunch and Poster Session

Session 2 | Chair: Martin Göpfert

14:00 Miriam Goodman, Stanford University
C.elegans sensory channels

14:25 Lightning talk: Anthony Peng, University of Colorado Anschutz
Is climbing and slipping the true model for myosin motor adaptation in mammalian hair cells?

14:30 David Corey, Harvard University:
The mammalian hair cell channel

14:55 Jeffrey Holt, Harvard University
The hair cell mechanotransduction channel

15:20 Lightning talk: Eric Mulhall, Harvard Medical School
The Dynamic Strength of the Tip-Link Bond in Hair Cells

15:25 Lightning talk: Philip Hehlert, Schwann-Schleiden Research Center
Mechano-gating properties of Drosophila NOMPC

15:30 Thomas Jentsch, Leibniz Institute for Molecular Pharmacology
Properties and roles of volume-regulated LRRC8/VRAC anion channels

15:55 Ulrich Müller, Johns Hopkins Baltimore
New molecular players in hair cell mechanotransduction

16:20 Lightning talk: Lightning talk: Frederick Schwaller, Max Delbrück Center for Molecular Medicine
Ush2A is a vibration sensor involved in touch

16:25  Elizabeth Haswell, Washington University
Mechanosensitive Ion Channels in Green Organisms

16:50 Lightning talk: Ivan Radin, Washington University, St. Louis
Evolution and adaptation of Piezo proteins in the green lineage

16:55 Lightning talk: Manuela Schmidt, MPI of Experimental Medicine
Regulation of Piezo2 function – novel insights from its interactome

17:05 Poster Session

19:05 Free evening

Friday, October 19, 2018

Max Delbrück Communications Center – MDC.C (House 83), Robert-Rössle-Straße 10, 13125 Berlin, Germany, Axon 1

Session 3 | Kate Poole

09:00 Paul Heppenstall, EMBL Monterotondo
Manipulating sensory transduction with genetic tools in mice

09:25 Lightning talk: Shefin George, Stanford University
Membrane lipid properties modulate hair cell mechanotransduction

09:30 Kate Poole, University of New South Wales
Chondrocyte mechanotransduction

09:55 Lightning talk: Lightning talk: Michael Dudek, University of Manchester
The Trpv4 channel is involved in setting the pace of the circadian clock in cartilage and intervertebral discs

10:00 Anthony Ricci, Stanford University
The emerging role of the lipid bilayer in regulating hair cell mechanotransduction

10:25 Lightning talk: Lightning talk: Chonglin Guan, Georg August University of Goettingen
Myosin–dependent mechanosensory adaptation in Drosophila

10:30 Coffee Break

11:00 Eric Honore, CNRS Nice
Piezos roles in regulating vascular tone

11:25 Lightning talk: Zhongjie Ye, Scuola Internazionale Superiore di Studi Avanzati
Unfolding of mechanosensitive channels Piezo1 and Piezo2

11:30 Valeria Vásquez, University of Tennessee
Fine-tuning ion channel gating with dietary fatty acids

11:55 Lightning talk: Sylvia Fechner, Stanford University, School of Medicine
Composition of native met channels responsible for gentle touch sensation

12:00 Medha Pathak, University of California, Irvine
Piezo1 activation gains traction​​​​​​

12:25 Lightning talk: Angela Schlegel, Washington University, Saint Louis
Channel Behavior of the Mechanosensitive Ion Channel MscS-Like 1 is Modulated by Charged Pore-Lining and Soluble Domain Cys Residues

12:30 Lunch and Poster Session

Session 4 | Chair: Lily Jan

14:30 Gary Lewin, MDC Berlin
Tethers in sensory transduction: man and mouse

14:55 Lightning talk: Johannes Elferich, Oregon Health and Science University
Structure of the PCDH15/LHFPL5 complex at the lower insertion point of the mammalian hair cell tip link

15:00 Steve Brohawn, University of California, Berkeley
Mechanosensitive Potassium Channel Structure and Function

15:25 Lightning talk: Jerome Lacroix, Western University of Health Sciences
Identification of the Binding Site of a Piezo1-Selective Small Molecule Agonist

15:30 Coffee Break

16:00 Merritt Maduke, Stanford University
Mechanosensitive channels in ultrasonic neuromodulation

16:25 Lightning talk: Christopher Cunningham, Johns Hopkins University
Transmembrane-O-methyltransferase (TOMT) regulates localization of TMC proteins to stereocilia in cochlear hair cells

16:30 Ardem Patapoutian, HHMI Scripps Research Institute
Piezo ion channel structure and function

16:55 Lightning talk: Daniel Tracey; Indiana University
Proprioceptive neurons in larvae of Drosophila melanogaster show direction selective responses that require the mechanosensory channel TMC

Saturday, October 20, 2018

Max Delbrück Communications Center – MDC.C (House 83), Robert-Rössle-Straße 10, 13125 Berlin, Germany, Axon 1

Session 5 | Chair: Miriam Goodman

09:30 Boris Martinac, University of New South Wales
Bacterial mechanotransduction channels

09:55 Lightning talk: Allen Liu, University of Michigan
Mechanogenetics: Repurposing bacterial mechanosensitive channel MscL in mammalian cells

10:00 Carsten Grashoff, MPI for Biochemistry
Piconewton-sensitive biosensors to investigate molecular forces in cells

10:25 Lightning talk: Allen Liu, University of Michigan
Mechanogenetics: Repurposing bacterial mechanosensitive channel MscL in mammalian cells

10:30 Coffee Break

11:00 Yuh Nung Jan, University of California, San Francisco
Structure of drosophila mechanotransduction TRP channels

11:25 Lightning talk: Oscar Sanchez Carranza, Max Delbrück Center for Molecular Medicine
Voltage-gating of mechanosensitive Piezo channels

11:30 Bailong Xiao, School of Pharmaceutical Sciences, Tsinghua University
Structure and function of PIEZO proteins

11:55 Lightning talk: Anders Enjin, Lund University
Humidity sensing in insects

12:00 Lunch and Poster Session

14:00 Stefan Lechner, University of Heidelberg
Sensory transduction regulation

14:25 Closing remarks, Farewell

15:00 End of Conference


Prof. Gary Lewin