© Pixabay Hübner Lab Genetics and Genomics of Cardiovascular Diseases Profile Team Research Publications News Profile Team Research Publications News Profile Team Group Leader Prof. Dr. Norbert Hübner 87: Timoféeff-Ressovsky-Haus Room: 0.09 nhuebner@mdc-berlin.de +49 30 9406-2530 Scientist Dr. Eleonora Adami Eleonora.Adami@mdc-berlin.de Lucia Cocera Ortega Dr. med. Alena Laschtowitz 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Ning Liang 87: Timoféeff-Ressovsky-Haus Room: 0.10 Ning.Liang@mdc-berlin.de +49 30 9406-4384 Dr. Henrike Maatz 87: Timoféeff-Ressovsky-Haus Room: 0.06 h.maatz@mdc-berlin.de +49 30 9406-3037 Dr. Alvaro Perdomo Sabogal Alvaro.Perdomo@mdc-berlin.de Dr. Jorge Ruiz Orera 87: Timoféeff-Ressovsky-Haus Room: 0.17 Jorge.RuizOrera@mdc-berlin.de +49 30 9406-2930 Dr. Kathrin Saar 87: Timoféeff-Ressovsky-Haus Room: 0.06 ksaar@mdc-berlin.de +49 30 9406-3534 Jana Felicitas Schulz 87: Timoféeff-Ressovsky-Haus Room: 0.17 JanaFelicitas.Schulz@mdc-berlin.de +49 30 9406-3430 Secretariat Sabine Meier 87: Timoféeff-Ressovsky-Haus Room: 0.07 Sabine.Meier@mdc-berlin.de +49 30 9406-3512 Technical Assistants Susanne Blachut 87: Timoféeff-Ressovsky-Haus Room: 0.50 s.Blachut@mdc-berlin.de +49 30 9406-3269 Mathias Gerhard 87: Timoféeff-Ressovsky-Haus Room: 0.13 Oliver Hummel 87: Timoféeff-Ressovsky-Haus Room: 0.10 o.hummel@mdc-berlin.de Claudia Langnick 87: Timoféeff-Ressovsky-Haus Room: 0.50 claudia.langnick@mdc-berlin.de +49 30 9406-2527 Dr. Giannino Patone 87: Timoféeff-Ressovsky-Haus Room: 0.10 Giannino.Patone@mdc-berlin.de +49 30 9406-3441 Sabine Schmidt 87: Timoféeff-Ressovsky-Haus Room: 0.22 PhD student Nikita Shyam Dewani 87: Timoféeff-Ressovsky-Haus Room: 0.17 Nikita.Dewani@mdc-berlin.de +49 30 9406-2930 Johannes Greiner 87: Timoféeff-Ressovsky-Haus Room: 0.13 Johannes.Greiner@mdc-berlin.de +49 30 9406-2531 Laura Anne Liebig 87: Timoféeff-Ressovsky-Haus Room: 0.13 LauraAnne.Liebig@mdc-berlin.de +49 30 9406-2531 Eric Lars-Helge Lindberg 87: Timoféeff-Ressovsky-Haus Room: 0.17 +49 30 9406-3430 Anna Myronova 87: Timoféeff-Ressovsky-Haus Room: 0.13 Anna.Myronova@mdc-berlin.de +49 30 9406-2531 Nikolay Shvetsov 87: Timoféeff-Ressovsky-Haus Room: 0.13 Nikolay.Shvetsov@mdc-berlin.de +49 30 9406-2531 Graduate and Undergraduate Aliki Grammatikaki 87: Timoféeff-Ressovsky-Haus Room: 0.17 Aliki.Grammatikaki@mdc-berlin.de Research Medical Genomics and Genetics of Cardiovascular and Metabolic Diseases Publications March 16, 2023 / Mol Cell Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames C.L. Sandmann J.F. Schulz J. Ruiz-Orera M. Kirchner M. Ziehm E. Adami M. Marczenke A. Christ N. Liebe J. Greiner A. Schoenenberger M.B. Mücke N. Liang R.L. Moritz Z. Sun E.W. Deutsch M. Gotthardt J.M. Mudge J.R. Prensner T.E. Willnow P. Mertins S. van Heesch N. Hubner March 16, 2023 / Nat Ecol Evol Evolution and implications of de novo genes in humans L.A. Broeils J. Ruiz-Orera B. Snel N. Hubner S. van Heesch March 07, 2023 / Nucleic Acids Res Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart I. Milenkovic H.G. Santos Vieira M.C. Lucas J. Ruiz-Orera G. Patone S. Kesteven J. Wu M. Feneley G. Espadas E. Sabidó N. Hübner S. van Heesch M. Völkers E.M. Novoa February 01, 2023 / J Cardiovasc Transl Res LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide N.M. Quaife S. Chothani J.F. Schulz E.L. Lindberg K. Vanezis E. Adami K. O'Fee J. Greiner M. Litviňuková S. van Heesch N. Whiffin N. Hubner S. Schafer O. Rackham S.A. Cook P.J.R. Barton December 20, 2022 / Nat Rev Cardiol Single-cell transcriptomics for the assessment of cardiac disease A.M.A. Miranda V. Janbandhu H. Maatz K. Kanemaru J. Cranley S.A. Teichmann N. Huebner M.D. Schneider R.P. Harvey M. Noseda December 06, 2022 / Circulation Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage M. Ercu M.B. Mücke T. Pallien L. Markó A. Sholokh C. Schächterle A. Aydin A. Kidd S. Walter Y. Esmati B.J. McMurray D.F. Lato D.Y. Sunaga-Franze P.H. Dierks B.I.M. Flores R. Walker-Gray M. Gong C. Merticariu K. Zühlke M. Russwurm T. Liu T.U.P. Batolomaeus S. Pautz S. Schelenz M. Taube H. Napieczynska A. Heuser J. Eichhorst M. Lehmann D.C. Miller S. Diecke F. Qadri E. Popova R. Langanki M.A. Movsesian F.W. Herberg S.K. Forslund D.N. Müller T. Borodina P.G. Maass S. Bähring N. Hübner M. Bader E. Klussmann December 05, 2022 / Nat Commun Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease A.A. Widjaja S. Viswanathan S.G. Shekeran E. Adami W.W. Lim S. Chothani J. Tan J.W.T. Goh H.M. Chen S.Y. Lim C.M. Boustany-Kari J. Hawkins E. Petretto N. Hübner S. Schafer T.M. Coffman S.A. Cook December 01, 2022 / NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert November 11, 2022 / Nat Commun pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation O. Boix M. Martinez S. Vidal M. Giménez-Alejandre L. Palenzuela L. Lorenzo-Sanz L. Quevedo O. Moscoso J. Ruiz-Orera P. Ximénez-Embún N. Ciriaco P. Nuciforo C. Stephan-Otto Attolini M.M. Albà J. Muñoz T.V. Tian I. Varela A. Vivancos S. Ramón Y Cajal P. Muñoz C. Rivas M. Abad October 06, 2022 / Mol Cel SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA S. Maharana S. Kretschmer S. Hunger X. Yan D. Kuster S. Traikov T. Zillinger M. Gentzel S. Elangovan P. Dasgupta N. Chappidi N. Lucas K.I. Maser H. Maatz A. Rapp V. Marchand Y.T. Chang Y. Motorin N. Hubner G. Hartmann A.A. Hyman S. Alberti M.A. Lee-Kirsch Pagination Current page 1 Page 2 Page 3 Page 4 … Next page ›› Last page Last » News Institute & Campus February 28, 2023 📺 Lunch Break: Science and Art help to make sense of the world Dr. Eleonora Adami is a postdoctoral research fellow at the Max Delbrück Center. The molecular biologist and geneticist studies heart failure by applying single-cell genomics approaches in the Hübner lab. Press Release No. 9 February 17, 2023 Berlin Evolution: Miniproteins appeared “from nowhere” Evolutionarily young miniproteins are unique in humans, and researchers have recently discovered thousands of them. Writing in Molecular Cell, Norbert Hübner and colleagues from the BIH and other institutions describe the origins of these tiny proteins and explain that they probably influence important cellular processes. Press Release No. 48 October 19, 2022 Berlin No heart damage despite hypertension An overactive enzyme that causes an inherited form of high blood pressure also appears to protect against hypertension-induced cardiac damage. A team of researchers from the Max Delbrück Center, ECRC, and DZHK led by Enno Klußmann explains in the journal Circulation how this could fundamentally change the way hearts can be protected from damage. Press Release No. 36 August 04, 2022 Berlin How pathogenic gene variants lead to heart failure Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports in “Science”. MDC researcher Norbert Hübner is one of the senior authors. Press Release No. 32 July 13, 2022 Berlin Unchartered territory in the human genome An international consortium brings together 7,200 segments of the human genome that are virtually unexplored and presents a roadmap for integrating them into genome databases in “Nature Biotechnology”. They could hold information about what sets humans apart from other animals. Science December 01, 2021 Towards a better understanding of heart failure The heart can get weak in different ways. One form of the disease, heart failure with preserved ejection fraction (HFpEF), continues to be extremely difficult to treat. MDC researchers are involved in a new Collaborative Research Center, where they aim to change this and develop therapeutic approaches. Science November 10, 2021 Loss of control in heart muscle cells Titin is the largest protein in the human body which takes on a central role in muscle fibers. A DZHK team now reports in „Science Translational Medicine“ how mutations in the titin gene can cause a disease of the heart muscle, dilated cardiomyopathy. Press Release No. 43 August 30, 2021 Berlin A cell atlas of the pediatric heart After providing funding for single-cell analysis of adult hearts, the Chan Zuckerberg Initiative is now supporting the creation of a cell atlas of children’s hearts. An international team led by Christine Seidman of Harvard University and Norbert Hübner of the MDC is again among the funded networks. Press Release No. 39 July 05, 2021 Berlin A glitch in the heart’s protein factory MDC researchers have discovered a previously unknown cause of cardiac hypertrophy. As they report in the journal “Genome Biology”, genetic variation results in heart cell ribosomes not working properly. This disrupts protein production, which in turn causes the heart to grow too large. Press Release No. 48 October 29, 2020 Berlin Not all hearts are the same An international research team recently created the first atlas of the human heart. Now the scientists want to add a new dimension to the project: diversity. They are being supported by an additional Seed Networks grant from the Chan Zuckerberg Initiative. Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page ›› Last page Last » Prof. Dr. Norbert Hübner Contact nhuebner@mdc-berlin.de Phone: +49 30 9406-2530 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Robert-Rössle-Straße 10 13125 Berlin, Deutschland Building 87, Room 0.09 Norbert Hübner is a DZHK Principal Investigator Research Topics Genetics & Genomics Gene Expression Regulation & RNA Biology Cardiovascular Research
Team Group Leader Prof. Dr. Norbert Hübner 87: Timoféeff-Ressovsky-Haus Room: 0.09 nhuebner@mdc-berlin.de +49 30 9406-2530 Scientist Dr. Eleonora Adami Eleonora.Adami@mdc-berlin.de Lucia Cocera Ortega Dr. med. Alena Laschtowitz 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Ning Liang 87: Timoféeff-Ressovsky-Haus Room: 0.10 Ning.Liang@mdc-berlin.de +49 30 9406-4384 Dr. Henrike Maatz 87: Timoféeff-Ressovsky-Haus Room: 0.06 h.maatz@mdc-berlin.de +49 30 9406-3037 Dr. Alvaro Perdomo Sabogal Alvaro.Perdomo@mdc-berlin.de Dr. Jorge Ruiz Orera 87: Timoféeff-Ressovsky-Haus Room: 0.17 Jorge.RuizOrera@mdc-berlin.de +49 30 9406-2930 Dr. Kathrin Saar 87: Timoféeff-Ressovsky-Haus Room: 0.06 ksaar@mdc-berlin.de +49 30 9406-3534 Jana Felicitas Schulz 87: Timoféeff-Ressovsky-Haus Room: 0.17 JanaFelicitas.Schulz@mdc-berlin.de +49 30 9406-3430 Secretariat Sabine Meier 87: Timoféeff-Ressovsky-Haus Room: 0.07 Sabine.Meier@mdc-berlin.de +49 30 9406-3512 Technical Assistants Susanne Blachut 87: Timoféeff-Ressovsky-Haus Room: 0.50 s.Blachut@mdc-berlin.de +49 30 9406-3269 Mathias Gerhard 87: Timoféeff-Ressovsky-Haus Room: 0.13 Oliver Hummel 87: Timoféeff-Ressovsky-Haus Room: 0.10 o.hummel@mdc-berlin.de Claudia Langnick 87: Timoféeff-Ressovsky-Haus Room: 0.50 claudia.langnick@mdc-berlin.de +49 30 9406-2527 Dr. Giannino Patone 87: Timoféeff-Ressovsky-Haus Room: 0.10 Giannino.Patone@mdc-berlin.de +49 30 9406-3441 Sabine Schmidt 87: Timoféeff-Ressovsky-Haus Room: 0.22 PhD student Nikita Shyam Dewani 87: Timoféeff-Ressovsky-Haus Room: 0.17 Nikita.Dewani@mdc-berlin.de +49 30 9406-2930 Johannes Greiner 87: Timoféeff-Ressovsky-Haus Room: 0.13 Johannes.Greiner@mdc-berlin.de +49 30 9406-2531 Laura Anne Liebig 87: Timoféeff-Ressovsky-Haus Room: 0.13 LauraAnne.Liebig@mdc-berlin.de +49 30 9406-2531 Eric Lars-Helge Lindberg 87: Timoféeff-Ressovsky-Haus Room: 0.17 +49 30 9406-3430 Anna Myronova 87: Timoféeff-Ressovsky-Haus Room: 0.13 Anna.Myronova@mdc-berlin.de +49 30 9406-2531 Nikolay Shvetsov 87: Timoféeff-Ressovsky-Haus Room: 0.13 Nikolay.Shvetsov@mdc-berlin.de +49 30 9406-2531 Graduate and Undergraduate Aliki Grammatikaki 87: Timoféeff-Ressovsky-Haus Room: 0.17 Aliki.Grammatikaki@mdc-berlin.de
Publications March 16, 2023 / Mol Cell Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames C.L. Sandmann J.F. Schulz J. Ruiz-Orera M. Kirchner M. Ziehm E. Adami M. Marczenke A. Christ N. Liebe J. Greiner A. Schoenenberger M.B. Mücke N. Liang R.L. Moritz Z. Sun E.W. Deutsch M. Gotthardt J.M. Mudge J.R. Prensner T.E. Willnow P. Mertins S. van Heesch N. Hubner March 16, 2023 / Nat Ecol Evol Evolution and implications of de novo genes in humans L.A. Broeils J. Ruiz-Orera B. Snel N. Hubner S. van Heesch March 07, 2023 / Nucleic Acids Res Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart I. Milenkovic H.G. Santos Vieira M.C. Lucas J. Ruiz-Orera G. Patone S. Kesteven J. Wu M. Feneley G. Espadas E. Sabidó N. Hübner S. van Heesch M. Völkers E.M. Novoa February 01, 2023 / J Cardiovasc Transl Res LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide N.M. Quaife S. Chothani J.F. Schulz E.L. Lindberg K. Vanezis E. Adami K. O'Fee J. Greiner M. Litviňuková S. van Heesch N. Whiffin N. Hubner S. Schafer O. Rackham S.A. Cook P.J.R. Barton December 20, 2022 / Nat Rev Cardiol Single-cell transcriptomics for the assessment of cardiac disease A.M.A. Miranda V. Janbandhu H. Maatz K. Kanemaru J. Cranley S.A. Teichmann N. Huebner M.D. Schneider R.P. Harvey M. Noseda December 06, 2022 / Circulation Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage M. Ercu M.B. Mücke T. Pallien L. Markó A. Sholokh C. Schächterle A. Aydin A. Kidd S. Walter Y. Esmati B.J. McMurray D.F. Lato D.Y. Sunaga-Franze P.H. Dierks B.I.M. Flores R. Walker-Gray M. Gong C. Merticariu K. Zühlke M. Russwurm T. Liu T.U.P. Batolomaeus S. Pautz S. Schelenz M. Taube H. Napieczynska A. Heuser J. Eichhorst M. Lehmann D.C. Miller S. Diecke F. Qadri E. Popova R. Langanki M.A. Movsesian F.W. Herberg S.K. Forslund D.N. Müller T. Borodina P.G. Maass S. Bähring N. Hübner M. Bader E. Klussmann December 05, 2022 / Nat Commun Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease A.A. Widjaja S. Viswanathan S.G. Shekeran E. Adami W.W. Lim S. Chothani J. Tan J.W.T. Goh H.M. Chen S.Y. Lim C.M. Boustany-Kari J. Hawkins E. Petretto N. Hübner S. Schafer T.M. Coffman S.A. Cook December 01, 2022 / NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert November 11, 2022 / Nat Commun pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation O. Boix M. Martinez S. Vidal M. Giménez-Alejandre L. Palenzuela L. Lorenzo-Sanz L. Quevedo O. Moscoso J. Ruiz-Orera P. Ximénez-Embún N. Ciriaco P. Nuciforo C. Stephan-Otto Attolini M.M. Albà J. Muñoz T.V. Tian I. Varela A. Vivancos S. Ramón Y Cajal P. Muñoz C. Rivas M. Abad October 06, 2022 / Mol Cel SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA S. Maharana S. Kretschmer S. Hunger X. Yan D. Kuster S. Traikov T. Zillinger M. Gentzel S. Elangovan P. Dasgupta N. Chappidi N. Lucas K.I. Maser H. Maatz A. Rapp V. Marchand Y.T. Chang Y. Motorin N. Hubner G. Hartmann A.A. Hyman S. Alberti M.A. Lee-Kirsch Pagination Current page 1 Page 2 Page 3 Page 4 … Next page ›› Last page Last »
March 16, 2023 / Mol Cell Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames C.L. Sandmann J.F. Schulz J. Ruiz-Orera M. Kirchner M. Ziehm E. Adami M. Marczenke A. Christ N. Liebe J. Greiner A. Schoenenberger M.B. Mücke N. Liang R.L. Moritz Z. Sun E.W. Deutsch M. Gotthardt J.M. Mudge J.R. Prensner T.E. Willnow P. Mertins S. van Heesch N. Hubner
March 16, 2023 / Nat Ecol Evol Evolution and implications of de novo genes in humans L.A. Broeils J. Ruiz-Orera B. Snel N. Hubner S. van Heesch
March 07, 2023 / Nucleic Acids Res Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart I. Milenkovic H.G. Santos Vieira M.C. Lucas J. Ruiz-Orera G. Patone S. Kesteven J. Wu M. Feneley G. Espadas E. Sabidó N. Hübner S. van Heesch M. Völkers E.M. Novoa
February 01, 2023 / J Cardiovasc Transl Res LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide N.M. Quaife S. Chothani J.F. Schulz E.L. Lindberg K. Vanezis E. Adami K. O'Fee J. Greiner M. Litviňuková S. van Heesch N. Whiffin N. Hubner S. Schafer O. Rackham S.A. Cook P.J.R. Barton
December 20, 2022 / Nat Rev Cardiol Single-cell transcriptomics for the assessment of cardiac disease A.M.A. Miranda V. Janbandhu H. Maatz K. Kanemaru J. Cranley S.A. Teichmann N. Huebner M.D. Schneider R.P. Harvey M. Noseda
December 06, 2022 / Circulation Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage M. Ercu M.B. Mücke T. Pallien L. Markó A. Sholokh C. Schächterle A. Aydin A. Kidd S. Walter Y. Esmati B.J. McMurray D.F. Lato D.Y. Sunaga-Franze P.H. Dierks B.I.M. Flores R. Walker-Gray M. Gong C. Merticariu K. Zühlke M. Russwurm T. Liu T.U.P. Batolomaeus S. Pautz S. Schelenz M. Taube H. Napieczynska A. Heuser J. Eichhorst M. Lehmann D.C. Miller S. Diecke F. Qadri E. Popova R. Langanki M.A. Movsesian F.W. Herberg S.K. Forslund D.N. Müller T. Borodina P.G. Maass S. Bähring N. Hübner M. Bader E. Klussmann
December 05, 2022 / Nat Commun Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease A.A. Widjaja S. Viswanathan S.G. Shekeran E. Adami W.W. Lim S. Chothani J. Tan J.W.T. Goh H.M. Chen S.Y. Lim C.M. Boustany-Kari J. Hawkins E. Petretto N. Hübner S. Schafer T.M. Coffman S.A. Cook
December 01, 2022 / NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert
November 11, 2022 / Nat Commun pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation O. Boix M. Martinez S. Vidal M. Giménez-Alejandre L. Palenzuela L. Lorenzo-Sanz L. Quevedo O. Moscoso J. Ruiz-Orera P. Ximénez-Embún N. Ciriaco P. Nuciforo C. Stephan-Otto Attolini M.M. Albà J. Muñoz T.V. Tian I. Varela A. Vivancos S. Ramón Y Cajal P. Muñoz C. Rivas M. Abad
October 06, 2022 / Mol Cel SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA S. Maharana S. Kretschmer S. Hunger X. Yan D. Kuster S. Traikov T. Zillinger M. Gentzel S. Elangovan P. Dasgupta N. Chappidi N. Lucas K.I. Maser H. Maatz A. Rapp V. Marchand Y.T. Chang Y. Motorin N. Hubner G. Hartmann A.A. Hyman S. Alberti M.A. Lee-Kirsch
News Institute & Campus February 28, 2023 📺 Lunch Break: Science and Art help to make sense of the world Dr. Eleonora Adami is a postdoctoral research fellow at the Max Delbrück Center. The molecular biologist and geneticist studies heart failure by applying single-cell genomics approaches in the Hübner lab. Press Release No. 9 February 17, 2023 Berlin Evolution: Miniproteins appeared “from nowhere” Evolutionarily young miniproteins are unique in humans, and researchers have recently discovered thousands of them. Writing in Molecular Cell, Norbert Hübner and colleagues from the BIH and other institutions describe the origins of these tiny proteins and explain that they probably influence important cellular processes. Press Release No. 48 October 19, 2022 Berlin No heart damage despite hypertension An overactive enzyme that causes an inherited form of high blood pressure also appears to protect against hypertension-induced cardiac damage. A team of researchers from the Max Delbrück Center, ECRC, and DZHK led by Enno Klußmann explains in the journal Circulation how this could fundamentally change the way hearts can be protected from damage. Press Release No. 36 August 04, 2022 Berlin How pathogenic gene variants lead to heart failure Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports in “Science”. MDC researcher Norbert Hübner is one of the senior authors. Press Release No. 32 July 13, 2022 Berlin Unchartered territory in the human genome An international consortium brings together 7,200 segments of the human genome that are virtually unexplored and presents a roadmap for integrating them into genome databases in “Nature Biotechnology”. They could hold information about what sets humans apart from other animals. Science December 01, 2021 Towards a better understanding of heart failure The heart can get weak in different ways. One form of the disease, heart failure with preserved ejection fraction (HFpEF), continues to be extremely difficult to treat. MDC researchers are involved in a new Collaborative Research Center, where they aim to change this and develop therapeutic approaches. Science November 10, 2021 Loss of control in heart muscle cells Titin is the largest protein in the human body which takes on a central role in muscle fibers. A DZHK team now reports in „Science Translational Medicine“ how mutations in the titin gene can cause a disease of the heart muscle, dilated cardiomyopathy. Press Release No. 43 August 30, 2021 Berlin A cell atlas of the pediatric heart After providing funding for single-cell analysis of adult hearts, the Chan Zuckerberg Initiative is now supporting the creation of a cell atlas of children’s hearts. An international team led by Christine Seidman of Harvard University and Norbert Hübner of the MDC is again among the funded networks. Press Release No. 39 July 05, 2021 Berlin A glitch in the heart’s protein factory MDC researchers have discovered a previously unknown cause of cardiac hypertrophy. As they report in the journal “Genome Biology”, genetic variation results in heart cell ribosomes not working properly. This disrupts protein production, which in turn causes the heart to grow too large. Press Release No. 48 October 29, 2020 Berlin Not all hearts are the same An international research team recently created the first atlas of the human heart. Now the scientists want to add a new dimension to the project: diversity. They are being supported by an additional Seed Networks grant from the Chan Zuckerberg Initiative. Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page ›› Last page Last »
Institute & Campus February 28, 2023 📺 Lunch Break: Science and Art help to make sense of the world Dr. Eleonora Adami is a postdoctoral research fellow at the Max Delbrück Center. The molecular biologist and geneticist studies heart failure by applying single-cell genomics approaches in the Hübner lab.
Press Release No. 9 February 17, 2023 Berlin Evolution: Miniproteins appeared “from nowhere” Evolutionarily young miniproteins are unique in humans, and researchers have recently discovered thousands of them. Writing in Molecular Cell, Norbert Hübner and colleagues from the BIH and other institutions describe the origins of these tiny proteins and explain that they probably influence important cellular processes.
Press Release No. 48 October 19, 2022 Berlin No heart damage despite hypertension An overactive enzyme that causes an inherited form of high blood pressure also appears to protect against hypertension-induced cardiac damage. A team of researchers from the Max Delbrück Center, ECRC, and DZHK led by Enno Klußmann explains in the journal Circulation how this could fundamentally change the way hearts can be protected from damage.
Press Release No. 36 August 04, 2022 Berlin How pathogenic gene variants lead to heart failure Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports in “Science”. MDC researcher Norbert Hübner is one of the senior authors.
Press Release No. 32 July 13, 2022 Berlin Unchartered territory in the human genome An international consortium brings together 7,200 segments of the human genome that are virtually unexplored and presents a roadmap for integrating them into genome databases in “Nature Biotechnology”. They could hold information about what sets humans apart from other animals.
Science December 01, 2021 Towards a better understanding of heart failure The heart can get weak in different ways. One form of the disease, heart failure with preserved ejection fraction (HFpEF), continues to be extremely difficult to treat. MDC researchers are involved in a new Collaborative Research Center, where they aim to change this and develop therapeutic approaches.
Science November 10, 2021 Loss of control in heart muscle cells Titin is the largest protein in the human body which takes on a central role in muscle fibers. A DZHK team now reports in „Science Translational Medicine“ how mutations in the titin gene can cause a disease of the heart muscle, dilated cardiomyopathy.
Press Release No. 43 August 30, 2021 Berlin A cell atlas of the pediatric heart After providing funding for single-cell analysis of adult hearts, the Chan Zuckerberg Initiative is now supporting the creation of a cell atlas of children’s hearts. An international team led by Christine Seidman of Harvard University and Norbert Hübner of the MDC is again among the funded networks.
Press Release No. 39 July 05, 2021 Berlin A glitch in the heart’s protein factory MDC researchers have discovered a previously unknown cause of cardiac hypertrophy. As they report in the journal “Genome Biology”, genetic variation results in heart cell ribosomes not working properly. This disrupts protein production, which in turn causes the heart to grow too large.
Press Release No. 48 October 29, 2020 Berlin Not all hearts are the same An international research team recently created the first atlas of the human heart. Now the scientists want to add a new dimension to the project: diversity. They are being supported by an additional Seed Networks grant from the Chan Zuckerberg Initiative.
Prof. Dr. Norbert Hübner Contact nhuebner@mdc-berlin.de Phone: +49 30 9406-2530 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Robert-Rössle-Straße 10 13125 Berlin, Deutschland Building 87, Room 0.09 Norbert Hübner is a DZHK Principal Investigator