© Pixabay Hübner Lab Genetics and Genomics of Cardiovascular Diseases Profile Team Research Publications News Profile Team Research Publications News Profile Team Group Leader Prof. Dr. Norbert Hübner 87: Timoféeff-Ressovsky-Haus Room: 0.09 nhuebner@mdc-berlin.de +49 30 9406-2530 Scientist Dr. Eleonora Adami Eleonora.Adami@mdc-berlin.de Lucia Cocera Ortega Dr. med. Alena Laschtowitz 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Ning Liang 87: Timoféeff-Ressovsky-Haus Room: 0.10 Ning.Liang@mdc-berlin.de +49 30 9406-4384 Dr. Henrike Maatz 87: Timoféeff-Ressovsky-Haus Room: 0.06 h.maatz@mdc-berlin.de +49 30 9406-3037 Dr. Alvaro Perdomo Sabogal Alvaro.Perdomo@mdc-berlin.de Dr. Jorge Ruiz Orera 87: Timoféeff-Ressovsky-Haus Room: 0.17 Jorge.RuizOrera@mdc-berlin.de +49 30 9406-2930 Dr. Kathrin Saar 84: Hermann-von-Helmholtz-Haus Room: 1104 ksaar@mdc-berlin.de +49 30 9406-3534 Secretariat Sabine Meier 87: Timoféeff-Ressovsky-Haus Room: 0.07 Sabine.Meier@mdc-berlin.de +49 30 9406-3512 Technical Assistants Susanne Blachut 87: Timoféeff-Ressovsky-Haus Room: 0.50 s.Blachut@mdc-berlin.de +49 30 9406-3269 Mathias Gerhard 87: Timoféeff-Ressovsky-Haus Room: 0.13 Oliver Hummel 87: Timoféeff-Ressovsky-Haus Room: 0.10 o.hummel@mdc-berlin.de Claudia Langnick 87: Timoféeff-Ressovsky-Haus Room: 0.50 claudia.langnick@mdc-berlin.de +49 30 9406-2527 Dr. Giannino Patone 87: Timoféeff-Ressovsky-Haus Room: 0.10 Giannino.Patone@mdc-berlin.de +49 30 9406-3441 Sabine Schmidt 87: Timoféeff-Ressovsky-Haus Room: 0.22 PhD student Nikita Shyam Dewani 87: Timoféeff-Ressovsky-Haus Room: 0.17 Nikita.Dewani@mdc-berlin.de +49 30 9406-2930 Johannes Greiner 87: Timoféeff-Ressovsky-Haus Room: 0.13 Johannes.Greiner@mdc-berlin.de +49 30 9406-2531 Laura Anne Liebig 87: Timoféeff-Ressovsky-Haus Room: 0.13 LauraAnne.Liebig@mdc-berlin.de +49 30 9406-2531 Eric Lars-Helge Lindberg Anna Myronova 87: Timoféeff-Ressovsky-Haus Room: 0.13 Anna.Myronova@mdc-berlin.de +49 30 9406-2531 Nikolay Shvetsov 87: Timoféeff-Ressovsky-Haus Room: 0.13 Nikolay.Shvetsov@mdc-berlin.de +49 30 9406-2531 Research Medical Genomics and Genetics of Cardiovascular and Metabolic Diseases Publications August 11, 2023 / Mol Cell Proteomics What can Ribo-seq, immunopeptidomics, and proteomics tell us about the non-canonical proteome? J.R. Prensner J.G. Abelin L.W. Kok K.R. Clauser J.M. Mudge J. Ruiz-Orera M. Bassani-Sternberg R.L. Moritz E.W. Deutsch S. van Heesch July 27, 2023 / Nature Spatially resolved multiomics of human cardiac niches K. Kanemaru J. Cranley D. Muraro A.M.A. Miranda S.Y. Ho A. Wilbrey-Clark J. Patrick Pett K. Polanski L. Richardson M. Litvinukova R. Kumasaka Y. Qin Z. Jablonska C.I. Semprich L. Mach M. Dabrowska R. Richoz L. Bolt L. Mamanova R. Kapuge S.N. Barnett S. Perera C. Talavera-López I. Mulas K.T. Mahbubani Liz Tuck Lu Wang M.M. Huang M. Prete S. Pritchard J. Dark K. Saeb-Parsy M. Patel M.R. Clatworthy N. Hübner R.A. Chowdhury M. Noseda S.A. Teichmann June 23, 2023 / Nucleic Acids Res Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart I. Milenkovic H.G. Santos Vieira M.C. Lucas J. Ruiz-Orera G. Patone S. Kesteven J. Wu M. Feneley G. Espadas E. Sabidó N. Hübner S. van Heesch M. Völkers E.M. Novoa June 01, 2023 / Nat Ecol Evol Evolution and implications of de novo genes in humans L.A. Broeils J. Ruiz-Orera B. Snel N. Hubner S. van Heesch May 01, 2023 / Nat Rev Cardiol Single-cell transcriptomics for the assessment of cardiac disease A.M.A. Miranda V. Janbandhu H. Maatz K. Kanemaru J. Cranley S.A. Teichmann N. Huebner M.D. Schneider R.P. Harvey M. Noseda March 16, 2023 / Mol Cell Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames C.L. Sandmann J.F. Schulz J. Ruiz-Orera M. Kirchner M. Ziehm E. Adami M. Marczenke A. Christ N. Liebe J. Greiner A. Schoenenberger M.B. Mücke N. Liang R.L. Moritz Z. Sun E.W. Deutsch M. Gotthardt J.M. Mudge J.R. Prensner T.E. Willnow P. Mertins S. van Heesch N. Hubner February 01, 2023 / J Cardiovasc Transl Res LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide N.M. Quaife S. Chothani J.F. Schulz E.L. Lindberg K. Vanezis E. Adami K. O'Fee J. Greiner M. Litviňuková S. van Heesch N. Whiffin N. Hubner S. Schafer O. Rackham S.A. Cook P.J.R. Barton December 06, 2022 / Circulation Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage M. Ercu M.B. Mücke T. Pallien L. Markó A. Sholokh C. Schächterle A. Aydin A. Kidd S. Walter Y. Esmati B.J. McMurray D.F. Lato D.Y. Sunaga-Franze P.H. Dierks B.I.M. Flores R. Walker-Gray M. Gong C. Merticariu K. Zühlke M. Russwurm T. Liu T.U.P. Batolomaeus S. Pautz S. Schelenz M. Taube H. Napieczynska A. Heuser J. Eichhorst M. Lehmann D.C. Miller S. Diecke F. Qadri E. Popova R. Langanki M.A. Movsesian F.W. Herberg S.K. Forslund D.N. Müller T. Borodina P.G. Maass S. Bähring N. Hübner M. Bader E. Klussmann December 05, 2022 / Nat Commun Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease A.A. Widjaja S. Viswanathan S.G. Shekeran E. Adami W.W. Lim S. Chothani J. Tan J.W.T. Goh H.M. Chen S.Y. Lim C.M. Boustany-Kari J. Hawkins E. Petretto N. Hübner S. Schafer T.M. Coffman S.A. Cook December 01, 2022 / NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert Pagination Current page 1 Page 2 Page 3 Page 4 … Next page ›› Last page Last » News Science August 22, 2023 The discoverer of hearts Science has something exploratory about it, says Norbert Hübner. You never know exactly where you are heading. Despite this, cartographic works are the focus of his interest: the researcher creates atlases of the human heart. And amongst other things, he uses them to understand heart conditions better. Press Release No. 30 July 12, 2023 Berlin How cells make the heart beat British and German scientists created the most comprehensive cell atlas of the human heart. As reported in the journal “Nature”, it is the first to include the cells from which the heartbeat originates. Among other things, this data will provide a reference for studies on cardiac arrhythmias. Institute & Campus February 28, 2023 📺 Lunch Break: Science and Art help to make sense of the world Dr. Eleonora Adami is a postdoctoral research fellow at the Max Delbrück Center. The molecular biologist and geneticist studies heart failure by applying single-cell genomics approaches in the Hübner lab. Press Release No. 9 February 17, 2023 Berlin Evolution: Miniproteins appeared “from nowhere” Evolutionarily young miniproteins are unique in humans, and researchers have recently discovered thousands of them. Writing in Molecular Cell, Norbert Hübner and colleagues from the BIH and other institutions describe the origins of these tiny proteins and explain that they probably influence important cellular processes. Press Release No. 48 October 19, 2022 Berlin No heart damage despite hypertension An overactive enzyme that causes an inherited form of high blood pressure also appears to protect against hypertension-induced cardiac damage. A team of researchers from the Max Delbrück Center, ECRC, and DZHK led by Enno Klußmann explains in the journal Circulation how this could fundamentally change the way hearts can be protected from damage. Press Release No. 36 August 04, 2022 Berlin How pathogenic gene variants lead to heart failure Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports in “Science”. MDC researcher Norbert Hübner is one of the senior authors. Press Release No. 32 July 13, 2022 Berlin Unchartered territory in the human genome An international consortium brings together 7,200 segments of the human genome that are virtually unexplored and presents a roadmap for integrating them into genome databases in “Nature Biotechnology”. They could hold information about what sets humans apart from other animals. Science December 01, 2021 Towards a better understanding of heart failure The heart can get weak in different ways. One form of the disease, heart failure with preserved ejection fraction (HFpEF), continues to be extremely difficult to treat. MDC researchers are involved in a new Collaborative Research Center, where they aim to change this and develop therapeutic approaches. Science November 10, 2021 Loss of control in heart muscle cells Titin is the largest protein in the human body which takes on a central role in muscle fibers. A DZHK team now reports in „Science Translational Medicine“ how mutations in the titin gene can cause a disease of the heart muscle, dilated cardiomyopathy. Press Release No. 43 August 30, 2021 Berlin A cell atlas of the pediatric heart After providing funding for single-cell analysis of adult hearts, the Chan Zuckerberg Initiative is now supporting the creation of a cell atlas of children’s hearts. An international team led by Christine Seidman of Harvard University and Norbert Hübner of the MDC is again among the funded networks. Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page ›› Last page Last » Prof. Dr. Norbert Hübner Group Leader Contact nhuebner@mdc-berlin.de Phone: +49 30 9406-2530 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Robert-Rössle-Straße 10 13125 Berlin, Deutschland Building 87, Room 0.09 Norbert Hübner is a DZHK Principal Investigator Internal affiliations Genes, Cells and Cell‑based Medicine (topic 1) Research Topics Genetics & Genomics Gene Expression Regulation & RNA Biology Cardiovascular Research
Team Group Leader Prof. Dr. Norbert Hübner 87: Timoféeff-Ressovsky-Haus Room: 0.09 nhuebner@mdc-berlin.de +49 30 9406-2530 Scientist Dr. Eleonora Adami Eleonora.Adami@mdc-berlin.de Lucia Cocera Ortega Dr. med. Alena Laschtowitz 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Ning Liang 87: Timoféeff-Ressovsky-Haus Room: 0.10 Ning.Liang@mdc-berlin.de +49 30 9406-4384 Dr. Henrike Maatz 87: Timoféeff-Ressovsky-Haus Room: 0.06 h.maatz@mdc-berlin.de +49 30 9406-3037 Dr. Alvaro Perdomo Sabogal Alvaro.Perdomo@mdc-berlin.de Dr. Jorge Ruiz Orera 87: Timoféeff-Ressovsky-Haus Room: 0.17 Jorge.RuizOrera@mdc-berlin.de +49 30 9406-2930 Dr. Kathrin Saar 84: Hermann-von-Helmholtz-Haus Room: 1104 ksaar@mdc-berlin.de +49 30 9406-3534 Secretariat Sabine Meier 87: Timoféeff-Ressovsky-Haus Room: 0.07 Sabine.Meier@mdc-berlin.de +49 30 9406-3512 Technical Assistants Susanne Blachut 87: Timoféeff-Ressovsky-Haus Room: 0.50 s.Blachut@mdc-berlin.de +49 30 9406-3269 Mathias Gerhard 87: Timoféeff-Ressovsky-Haus Room: 0.13 Oliver Hummel 87: Timoféeff-Ressovsky-Haus Room: 0.10 o.hummel@mdc-berlin.de Claudia Langnick 87: Timoféeff-Ressovsky-Haus Room: 0.50 claudia.langnick@mdc-berlin.de +49 30 9406-2527 Dr. Giannino Patone 87: Timoféeff-Ressovsky-Haus Room: 0.10 Giannino.Patone@mdc-berlin.de +49 30 9406-3441 Sabine Schmidt 87: Timoféeff-Ressovsky-Haus Room: 0.22 PhD student Nikita Shyam Dewani 87: Timoféeff-Ressovsky-Haus Room: 0.17 Nikita.Dewani@mdc-berlin.de +49 30 9406-2930 Johannes Greiner 87: Timoféeff-Ressovsky-Haus Room: 0.13 Johannes.Greiner@mdc-berlin.de +49 30 9406-2531 Laura Anne Liebig 87: Timoféeff-Ressovsky-Haus Room: 0.13 LauraAnne.Liebig@mdc-berlin.de +49 30 9406-2531 Eric Lars-Helge Lindberg Anna Myronova 87: Timoféeff-Ressovsky-Haus Room: 0.13 Anna.Myronova@mdc-berlin.de +49 30 9406-2531 Nikolay Shvetsov 87: Timoféeff-Ressovsky-Haus Room: 0.13 Nikolay.Shvetsov@mdc-berlin.de +49 30 9406-2531
Publications August 11, 2023 / Mol Cell Proteomics What can Ribo-seq, immunopeptidomics, and proteomics tell us about the non-canonical proteome? J.R. Prensner J.G. Abelin L.W. Kok K.R. Clauser J.M. Mudge J. Ruiz-Orera M. Bassani-Sternberg R.L. Moritz E.W. Deutsch S. van Heesch July 27, 2023 / Nature Spatially resolved multiomics of human cardiac niches K. Kanemaru J. Cranley D. Muraro A.M.A. Miranda S.Y. Ho A. Wilbrey-Clark J. Patrick Pett K. Polanski L. Richardson M. Litvinukova R. Kumasaka Y. Qin Z. Jablonska C.I. Semprich L. Mach M. Dabrowska R. Richoz L. Bolt L. Mamanova R. Kapuge S.N. Barnett S. Perera C. Talavera-López I. Mulas K.T. Mahbubani Liz Tuck Lu Wang M.M. Huang M. Prete S. Pritchard J. Dark K. Saeb-Parsy M. Patel M.R. Clatworthy N. Hübner R.A. Chowdhury M. Noseda S.A. Teichmann June 23, 2023 / Nucleic Acids Res Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart I. Milenkovic H.G. Santos Vieira M.C. Lucas J. Ruiz-Orera G. Patone S. Kesteven J. Wu M. Feneley G. Espadas E. Sabidó N. Hübner S. van Heesch M. Völkers E.M. Novoa June 01, 2023 / Nat Ecol Evol Evolution and implications of de novo genes in humans L.A. Broeils J. Ruiz-Orera B. Snel N. Hubner S. van Heesch May 01, 2023 / Nat Rev Cardiol Single-cell transcriptomics for the assessment of cardiac disease A.M.A. Miranda V. Janbandhu H. Maatz K. Kanemaru J. Cranley S.A. Teichmann N. Huebner M.D. Schneider R.P. Harvey M. Noseda March 16, 2023 / Mol Cell Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames C.L. Sandmann J.F. Schulz J. Ruiz-Orera M. Kirchner M. Ziehm E. Adami M. Marczenke A. Christ N. Liebe J. Greiner A. Schoenenberger M.B. Mücke N. Liang R.L. Moritz Z. Sun E.W. Deutsch M. Gotthardt J.M. Mudge J.R. Prensner T.E. Willnow P. Mertins S. van Heesch N. Hubner February 01, 2023 / J Cardiovasc Transl Res LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide N.M. Quaife S. Chothani J.F. Schulz E.L. Lindberg K. Vanezis E. Adami K. O'Fee J. Greiner M. Litviňuková S. van Heesch N. Whiffin N. Hubner S. Schafer O. Rackham S.A. Cook P.J.R. Barton December 06, 2022 / Circulation Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage M. Ercu M.B. Mücke T. Pallien L. Markó A. Sholokh C. Schächterle A. Aydin A. Kidd S. Walter Y. Esmati B.J. McMurray D.F. Lato D.Y. Sunaga-Franze P.H. Dierks B.I.M. Flores R. Walker-Gray M. Gong C. Merticariu K. Zühlke M. Russwurm T. Liu T.U.P. Batolomaeus S. Pautz S. Schelenz M. Taube H. Napieczynska A. Heuser J. Eichhorst M. Lehmann D.C. Miller S. Diecke F. Qadri E. Popova R. Langanki M.A. Movsesian F.W. Herberg S.K. Forslund D.N. Müller T. Borodina P.G. Maass S. Bähring N. Hübner M. Bader E. Klussmann December 05, 2022 / Nat Commun Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease A.A. Widjaja S. Viswanathan S.G. Shekeran E. Adami W.W. Lim S. Chothani J. Tan J.W.T. Goh H.M. Chen S.Y. Lim C.M. Boustany-Kari J. Hawkins E. Petretto N. Hübner S. Schafer T.M. Coffman S.A. Cook December 01, 2022 / NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert Pagination Current page 1 Page 2 Page 3 Page 4 … Next page ›› Last page Last »
August 11, 2023 / Mol Cell Proteomics What can Ribo-seq, immunopeptidomics, and proteomics tell us about the non-canonical proteome? J.R. Prensner J.G. Abelin L.W. Kok K.R. Clauser J.M. Mudge J. Ruiz-Orera M. Bassani-Sternberg R.L. Moritz E.W. Deutsch S. van Heesch
July 27, 2023 / Nature Spatially resolved multiomics of human cardiac niches K. Kanemaru J. Cranley D. Muraro A.M.A. Miranda S.Y. Ho A. Wilbrey-Clark J. Patrick Pett K. Polanski L. Richardson M. Litvinukova R. Kumasaka Y. Qin Z. Jablonska C.I. Semprich L. Mach M. Dabrowska R. Richoz L. Bolt L. Mamanova R. Kapuge S.N. Barnett S. Perera C. Talavera-López I. Mulas K.T. Mahbubani Liz Tuck Lu Wang M.M. Huang M. Prete S. Pritchard J. Dark K. Saeb-Parsy M. Patel M.R. Clatworthy N. Hübner R.A. Chowdhury M. Noseda S.A. Teichmann
June 23, 2023 / Nucleic Acids Res Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart I. Milenkovic H.G. Santos Vieira M.C. Lucas J. Ruiz-Orera G. Patone S. Kesteven J. Wu M. Feneley G. Espadas E. Sabidó N. Hübner S. van Heesch M. Völkers E.M. Novoa
June 01, 2023 / Nat Ecol Evol Evolution and implications of de novo genes in humans L.A. Broeils J. Ruiz-Orera B. Snel N. Hubner S. van Heesch
May 01, 2023 / Nat Rev Cardiol Single-cell transcriptomics for the assessment of cardiac disease A.M.A. Miranda V. Janbandhu H. Maatz K. Kanemaru J. Cranley S.A. Teichmann N. Huebner M.D. Schneider R.P. Harvey M. Noseda
March 16, 2023 / Mol Cell Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames C.L. Sandmann J.F. Schulz J. Ruiz-Orera M. Kirchner M. Ziehm E. Adami M. Marczenke A. Christ N. Liebe J. Greiner A. Schoenenberger M.B. Mücke N. Liang R.L. Moritz Z. Sun E.W. Deutsch M. Gotthardt J.M. Mudge J.R. Prensner T.E. Willnow P. Mertins S. van Heesch N. Hubner
February 01, 2023 / J Cardiovasc Transl Res LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide N.M. Quaife S. Chothani J.F. Schulz E.L. Lindberg K. Vanezis E. Adami K. O'Fee J. Greiner M. Litviňuková S. van Heesch N. Whiffin N. Hubner S. Schafer O. Rackham S.A. Cook P.J.R. Barton
December 06, 2022 / Circulation Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage M. Ercu M.B. Mücke T. Pallien L. Markó A. Sholokh C. Schächterle A. Aydin A. Kidd S. Walter Y. Esmati B.J. McMurray D.F. Lato D.Y. Sunaga-Franze P.H. Dierks B.I.M. Flores R. Walker-Gray M. Gong C. Merticariu K. Zühlke M. Russwurm T. Liu T.U.P. Batolomaeus S. Pautz S. Schelenz M. Taube H. Napieczynska A. Heuser J. Eichhorst M. Lehmann D.C. Miller S. Diecke F. Qadri E. Popova R. Langanki M.A. Movsesian F.W. Herberg S.K. Forslund D.N. Müller T. Borodina P.G. Maass S. Bähring N. Hübner M. Bader E. Klussmann
December 05, 2022 / Nat Commun Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease A.A. Widjaja S. Viswanathan S.G. Shekeran E. Adami W.W. Lim S. Chothani J. Tan J.W.T. Goh H.M. Chen S.Y. Lim C.M. Boustany-Kari J. Hawkins E. Petretto N. Hübner S. Schafer T.M. Coffman S.A. Cook
December 01, 2022 / NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert
News Science August 22, 2023 The discoverer of hearts Science has something exploratory about it, says Norbert Hübner. You never know exactly where you are heading. Despite this, cartographic works are the focus of his interest: the researcher creates atlases of the human heart. And amongst other things, he uses them to understand heart conditions better. Press Release No. 30 July 12, 2023 Berlin How cells make the heart beat British and German scientists created the most comprehensive cell atlas of the human heart. As reported in the journal “Nature”, it is the first to include the cells from which the heartbeat originates. Among other things, this data will provide a reference for studies on cardiac arrhythmias. Institute & Campus February 28, 2023 📺 Lunch Break: Science and Art help to make sense of the world Dr. Eleonora Adami is a postdoctoral research fellow at the Max Delbrück Center. The molecular biologist and geneticist studies heart failure by applying single-cell genomics approaches in the Hübner lab. Press Release No. 9 February 17, 2023 Berlin Evolution: Miniproteins appeared “from nowhere” Evolutionarily young miniproteins are unique in humans, and researchers have recently discovered thousands of them. Writing in Molecular Cell, Norbert Hübner and colleagues from the BIH and other institutions describe the origins of these tiny proteins and explain that they probably influence important cellular processes. Press Release No. 48 October 19, 2022 Berlin No heart damage despite hypertension An overactive enzyme that causes an inherited form of high blood pressure also appears to protect against hypertension-induced cardiac damage. A team of researchers from the Max Delbrück Center, ECRC, and DZHK led by Enno Klußmann explains in the journal Circulation how this could fundamentally change the way hearts can be protected from damage. Press Release No. 36 August 04, 2022 Berlin How pathogenic gene variants lead to heart failure Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports in “Science”. MDC researcher Norbert Hübner is one of the senior authors. Press Release No. 32 July 13, 2022 Berlin Unchartered territory in the human genome An international consortium brings together 7,200 segments of the human genome that are virtually unexplored and presents a roadmap for integrating them into genome databases in “Nature Biotechnology”. They could hold information about what sets humans apart from other animals. Science December 01, 2021 Towards a better understanding of heart failure The heart can get weak in different ways. One form of the disease, heart failure with preserved ejection fraction (HFpEF), continues to be extremely difficult to treat. MDC researchers are involved in a new Collaborative Research Center, where they aim to change this and develop therapeutic approaches. Science November 10, 2021 Loss of control in heart muscle cells Titin is the largest protein in the human body which takes on a central role in muscle fibers. A DZHK team now reports in „Science Translational Medicine“ how mutations in the titin gene can cause a disease of the heart muscle, dilated cardiomyopathy. Press Release No. 43 August 30, 2021 Berlin A cell atlas of the pediatric heart After providing funding for single-cell analysis of adult hearts, the Chan Zuckerberg Initiative is now supporting the creation of a cell atlas of children’s hearts. An international team led by Christine Seidman of Harvard University and Norbert Hübner of the MDC is again among the funded networks. Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page ›› Last page Last »
Science August 22, 2023 The discoverer of hearts Science has something exploratory about it, says Norbert Hübner. You never know exactly where you are heading. Despite this, cartographic works are the focus of his interest: the researcher creates atlases of the human heart. And amongst other things, he uses them to understand heart conditions better.
Press Release No. 30 July 12, 2023 Berlin How cells make the heart beat British and German scientists created the most comprehensive cell atlas of the human heart. As reported in the journal “Nature”, it is the first to include the cells from which the heartbeat originates. Among other things, this data will provide a reference for studies on cardiac arrhythmias.
Institute & Campus February 28, 2023 📺 Lunch Break: Science and Art help to make sense of the world Dr. Eleonora Adami is a postdoctoral research fellow at the Max Delbrück Center. The molecular biologist and geneticist studies heart failure by applying single-cell genomics approaches in the Hübner lab.
Press Release No. 9 February 17, 2023 Berlin Evolution: Miniproteins appeared “from nowhere” Evolutionarily young miniproteins are unique in humans, and researchers have recently discovered thousands of them. Writing in Molecular Cell, Norbert Hübner and colleagues from the BIH and other institutions describe the origins of these tiny proteins and explain that they probably influence important cellular processes.
Press Release No. 48 October 19, 2022 Berlin No heart damage despite hypertension An overactive enzyme that causes an inherited form of high blood pressure also appears to protect against hypertension-induced cardiac damage. A team of researchers from the Max Delbrück Center, ECRC, and DZHK led by Enno Klußmann explains in the journal Circulation how this could fundamentally change the way hearts can be protected from damage.
Press Release No. 36 August 04, 2022 Berlin How pathogenic gene variants lead to heart failure Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports in “Science”. MDC researcher Norbert Hübner is one of the senior authors.
Press Release No. 32 July 13, 2022 Berlin Unchartered territory in the human genome An international consortium brings together 7,200 segments of the human genome that are virtually unexplored and presents a roadmap for integrating them into genome databases in “Nature Biotechnology”. They could hold information about what sets humans apart from other animals.
Science December 01, 2021 Towards a better understanding of heart failure The heart can get weak in different ways. One form of the disease, heart failure with preserved ejection fraction (HFpEF), continues to be extremely difficult to treat. MDC researchers are involved in a new Collaborative Research Center, where they aim to change this and develop therapeutic approaches.
Science November 10, 2021 Loss of control in heart muscle cells Titin is the largest protein in the human body which takes on a central role in muscle fibers. A DZHK team now reports in „Science Translational Medicine“ how mutations in the titin gene can cause a disease of the heart muscle, dilated cardiomyopathy.
Press Release No. 43 August 30, 2021 Berlin A cell atlas of the pediatric heart After providing funding for single-cell analysis of adult hearts, the Chan Zuckerberg Initiative is now supporting the creation of a cell atlas of children’s hearts. An international team led by Christine Seidman of Harvard University and Norbert Hübner of the MDC is again among the funded networks.
Prof. Dr. Norbert Hübner Group Leader Contact nhuebner@mdc-berlin.de Phone: +49 30 9406-2530 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Robert-Rössle-Straße 10 13125 Berlin, Deutschland Building 87, Room 0.09 Norbert Hübner is a DZHK Principal Investigator Internal affiliations Genes, Cells and Cell‑based Medicine (topic 1)