© Pixabay Hübner Lab Genetics and Genomics of Cardiovascular Diseases Profile Team Research Publications News Jobs Profile Team Research Publications News Jobs Profile Team Group Leader Prof. Dr. Norbert Hübner 87: Timoféeff-Ressovsky-Haus Room: 0.09 nhuebner@mdc-berlin.de +49 30 9406-2530 Scientist Dr. Eleonora Adami Eleonora.Adami@mdc-berlin.de Lucia Cocera Ortega Dr. med. Alena Laschtowitz 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Ning Liang 87: Timoféeff-Ressovsky-Haus Room: 0.10 Ning.Liang@mdc-berlin.de +49 30 9406-4384 Dr. Henrike Maatz 87: Timoféeff-Ressovsky-Haus Room: 0.06 h.maatz@mdc-berlin.de +49 30 9406-3037 Dr. Jorge Ruiz Orera 87: Timoféeff-Ressovsky-Haus Room: 0.17 Jorge.RuizOrera@mdc-berlin.de +49 30 9406-2930 Dr. Kathrin Saar 87: Timoféeff-Ressovsky-Haus Room: 0.06 ksaar@mdc-berlin.de +49 30 9406-3534 Technical Assistants Susanne Blachut 87: Timoféeff-Ressovsky-Haus Room: 0.50 s.Blachut@mdc-berlin.de +49 30 9406-3269 Mathias Gerhard 87: Timoféeff-Ressovsky-Haus Room: 0.13 Oliver Hummel 87: Timoféeff-Ressovsky-Haus Room: 0.10 o.hummel@mdc-berlin.de Claudia Langnick 87: Timoféeff-Ressovsky-Haus Room: 0.50 claudia.langnick@mdc-berlin.de +49 30 9406-2527 Dr. Giannino Patone 87: Timoféeff-Ressovsky-Haus Room: 0.10 Giannino.Patone@mdc-berlin.de +49 30 9406-3441 Sabine Schmidt 87: Timoféeff-Ressovsky-Haus Room: 0.22 PhD student Barbara Bellomo 87: Timoféeff-Ressovsky-Haus Room: 0.13 Barbara.Bellomo@mdc-berlin.de +49 30 9406-2531 Nikita Shyam Dewani 87: Timoféeff-Ressovsky-Haus Room: 0.17 Nikita.Dewani@mdc-berlin.de +49 30 9406-2930 Johannes Greiner 87: Timoféeff-Ressovsky-Haus Room: 0.13 Johannes.Greiner@mdc-berlin.de +49 30 9406-2531 Laura Anne Liebig 87: Timoféeff-Ressovsky-Haus Room: 0.13 LauraAnne.Liebig@mdc-berlin.de +49 30 9406-2531 Eric Lars-Helge Lindberg 87: Timoféeff-Ressovsky-Haus Room: 0.17 +49 30 9406-3430 Anna Myronova 87: Timoféeff-Ressovsky-Haus Room: 0.13 Anna.Myronova@mdc-berlin.de +49 30 9406-2531 Sandmann 87: Timoféeff-Ressovsky-Haus Room: 0.17 clara.sandmann@mdc-berlin.de +49 30 9406-2930 Jana Felicitas Schulz 87: Timoféeff-Ressovsky-Haus Room: 0.17 JanaFelicitas.Schulz@mdc-berlin.de +49 30 9406-3430 Nikolay Shvetsov 87: Timoféeff-Ressovsky-Haus Room: 0.13 Nikolay.Shvetsov@mdc-berlin.de +49 30 9406-2531 Graduate and Undergraduate Aliki Grammatikaki 87: Timoféeff-Ressovsky-Haus Room: 0.17 Aliki.Grammatikaki@mdc-berlin.de Juan Li 87: Timoféeff-Ressovsky-Haus Room: 0.50 Juan.Li@mdc-berlin.de Research Medical Genomics and Genetics of Cardiovascular and Metabolic Diseases Publications December 01, 2022 in NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert November 11, 2022 in Nat Commun pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation O. Boix M. Martinez S. Vidal M. Giménez-Alejandre L. Palenzuela L. Lorenzo-Sanz L. Quevedo O. Moscoso J. Ruiz-Orera P. Ximénez-Embún N. Ciriaco P. Nuciforo C. Stephan-Otto Attolini M.M. Albà J. Muñoz T.V. Tian I. Varela A. Vivancos S. Ramón Y Cajal P. Muñoz C. Rivas M. Abad October 19, 2022 in Circulation Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage M. Ercu M.B. Mücke T. Pallien L. Markó A. Sholokh C. Schächterle A. Aydin A. Kidd S. Walter Y. Esmati B.J. McMurray D.F. Lato D.Y. Sunaga-Franze P.H. Dierks B.I.M. Flores R. Walker-Gray M. Gong C. Merticariu K. Zühlke M. Russwurm T. Liu T.U.P. Batolomaeus S. Pautz S. Schelenz M. Taube H. Napieczynska A. Heuser J. Eichhorst M. Lehmann D.C. Miller S. Diecke F. Qadri E. Popova R. Langanki M.A. Movsesian F.W. Herberg S.K. Forslund D.N. Müller T. Borodina P.G. Maass S. Bähring N. Hübner M. Bader E. Klussmann October 06, 2022 in Mol Cel SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA S. Maharana S. Kretschmer S. Hunger X. Yan D. Kuster S. Traikov T. Zillinger M. Gentzel S. Elangovan P. Dasgupta N. Chappidi N. Lucas K.I. Maser H. Maatz A. Rapp V. Marchand Y.T. Chang Y. Motorin N. Hubner G. Hartmann A.A. Hyman S. Alberti M.A. Lee-Kirsch October 03, 2022 in Comput Struct Biotechnol J Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes S.A. Ansari W. Dantoft J. Ruiz-Orera A.P. Syed S. Blachut S. van Heesch N. Hübner N.H. Uhlenhaut October 01, 2022 in Hum Mutat Biallelic variants in WARS1 cause a highly variable neurodevelopmental syndrome and implicate a critical exon for normal auditory function S.J. Lin B. Vona H.M. Porter M. Izadi K. Huang Y. Lacassie J.A. Rosenfeld S. Khan C. Petree T.A. Ali N. Muhammad S.A. Khan N. Muhammad P. Liu M.L. Haymon F. Rüschendorf I.K. Kong L. Schnapp N. Shur L. Chorich L. Layman T. Haaf E. Pourkarimi H.G. Kim G.K. Varshney September 29, 2022 in PLoS ONE Aging-regulated TUG1 is dispensable for endothelial cell function A.T. Gimbel S. Koziarek K. Theodorou J.F. Schulz L. Stanicek V. Kremer T. Ali S. Günther S. Kumar H. Jo N. Hübner L. Maegdefessel S. Dimmeler S. van Heesch R.A. Boon August 11, 2022 in Eur J Hum Genet Identification of novel genes whose expression in adipose tissue affects body fat mass and distribution: an RNA-Seq and Mendelian Randomization study S. Konigorski J. Janke G. Patone M.M. Bergmann C. Lippert N. Hübner R. Kaaks H. Boeing T. Pischon August 05, 2022 in Science Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies D. Reichart E.L. Lindberg H. Maatz A.M.A. Miranda A. Viveiros N. Shvetsov A. Gärtner E.R. Nadelmann M. Lee K. Kanemaru J. Ruiz-Orera V. Strohmenger D.M. DeLaughter G. Patone H. Zhang A. Woehler C. Lippert Y. Kim E. Adami J.M. Gorham S.N. Barnett K. Brown R.J. Buchan R.A. Chowdhury C. Constantinou J. Cranley L.E. Felkin H. Fox A. Ghauri J. Gummert M. Kanda R. Li L. Mach B. McDonough S. Samari F. Shahriaran C. Yapp C. Stanasiuk P.I. Theotokis F.J. Theis A. van den Bogaerdt H. Wakimoto J.S. Ware C.L. Worth P.J.R. Barton Y.A. Lee S.A. Teichmann H. Milting M. Noseda G.Y. Oudit M. Heinig J.G. Seidman N. Hubner C.E. Seidman August 04, 2022 in Mol Cell A high-resolution map of human RNA translation S.P. Chothani E. Adami A.A. Widjaja S.R. Langley S. Viswanathan C.J. Pua N.T. Zhihao N. Harmston G. D'Agostino N. Whiffin W. Mao J.F. Ouyang W.W. Lim S. Lim C.Q.E. Lee A. Grubman J. Chen J.P. Kovalik K. Tryggvason J.M. Polo L. Ho S.A. Cook O.J.L. Rackham S. Schafer Pagination Current page 1 Page 2 Page 3 Page 4 … Next page ›› Last page Last » News Press Release No. 48 October 19, 2022 Berlin No heart damage despite hypertension An overactive enzyme that causes an inherited form of high blood pressure also appears to protect against hypertension-induced cardiac damage. A team of researchers from the Max Delbrück Center, ECRC, and DZHK led by Enno Klußmann explains in the journal Circulation how this could fundamentally change the way hearts can be protected from damage. Press Release No. 36 August 04, 2022 Berlin How pathogenic gene variants lead to heart failure Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports in “Science”. MDC researcher Norbert Hübner is one of the senior authors. Press Release No. 32 July 13, 2022 Berlin Unchartered territory in the human genome An international consortium brings together 7,200 segments of the human genome that are virtually unexplored and presents a roadmap for integrating them into genome databases in “Nature Biotechnology”. They could hold information about what sets humans apart from other animals. Science December 01, 2021 Towards a better understanding of heart failure The heart can get weak in different ways. One form of the disease, heart failure with preserved ejection fraction (HFpEF), continues to be extremely difficult to treat. MDC researchers are involved in a new Collaborative Research Center, where they aim to change this and develop therapeutic approaches. Science November 10, 2021 Loss of control in heart muscle cells Titin is the largest protein in the human body which takes on a central role in muscle fibers. A DZHK team now reports in „Science Translational Medicine“ how mutations in the titin gene can cause a disease of the heart muscle, dilated cardiomyopathy. Press Release No. 43 August 30, 2021 Berlin A cell atlas of the pediatric heart After providing funding for single-cell analysis of adult hearts, the Chan Zuckerberg Initiative is now supporting the creation of a cell atlas of children’s hearts. An international team led by Christine Seidman of Harvard University and Norbert Hübner of the MDC is again among the funded networks. Press Release No. 39 July 05, 2021 Berlin A glitch in the heart’s protein factory MDC researchers have discovered a previously unknown cause of cardiac hypertrophy. As they report in the journal “Genome Biology”, genetic variation results in heart cell ribosomes not working properly. This disrupts protein production, which in turn causes the heart to grow too large. Press Release No. 48 October 29, 2020 Berlin Not all hearts are the same An international research team recently created the first atlas of the human heart. Now the scientists want to add a new dimension to the project: diversity. They are being supported by an additional Seed Networks grant from the Chan Zuckerberg Initiative. Press Release No. 42 September 24, 2020 Berlin An in-depth atlas of the heart Researchers from three continents have produced a first extensive draft of a cell atlas of the human heart to understand how this vital organ functions and to shed light on what goes wrong in cardiovascular disease. As the team reports in Nature, it reveals a huge cellular and molecular diversity. Press Release No. 18 April 23, 2020 Berlin Likely Entrypoints for SARS-CoV-2 Two specific cell types in the nose have been identified as likely initial infection points for the novel coronavirus that causes COVID-19. Using data from the Human Cell Atlas, scientists discovered that goblet and ciliated cells in the nose have high levels of the entry proteins that SARS-CoV-2 uses to get into our cells. Pagination Current page 1 Page 2 Page 3 Page 4 Next page ›› Last page Last » Jobs Starts November 28, 2022 secretary October 20, 2022 Fremdsprachensekretär*in (m/w/d) Genetics and Genomics of Cardiovascular Diseases Für die Arbeitsgruppe „Genetik und Genomik von Herz-Kreislauferkrankungen“ am Max-Delbrück-Centrum für Molekulare Medizin (MDC) in Berlin-Buch wird zum nächstmöglichen Zeitpunkt (01.12.2022 oder früher) ein*e Fremdsprachensekretär*in in Vollzeit gesucht. Prof. Dr. Norbert Hübner Contact nhuebner@mdc-berlin.de Phone: +49 30 9406-2530 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Robert-Rössle-Straße 10 13125 Berlin, Deutschland Building 87, Room 0.09 Norbert Hübner is a DZHK Principal Investigator Research Topics Genetics & Genomics Gene Expression Regulation & RNA Biology Cardiovascular Research
Team Group Leader Prof. Dr. Norbert Hübner 87: Timoféeff-Ressovsky-Haus Room: 0.09 nhuebner@mdc-berlin.de +49 30 9406-2530 Scientist Dr. Eleonora Adami Eleonora.Adami@mdc-berlin.de Lucia Cocera Ortega Dr. med. Alena Laschtowitz 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Ning Liang 87: Timoféeff-Ressovsky-Haus Room: 0.10 Ning.Liang@mdc-berlin.de +49 30 9406-4384 Dr. Henrike Maatz 87: Timoféeff-Ressovsky-Haus Room: 0.06 h.maatz@mdc-berlin.de +49 30 9406-3037 Dr. Jorge Ruiz Orera 87: Timoféeff-Ressovsky-Haus Room: 0.17 Jorge.RuizOrera@mdc-berlin.de +49 30 9406-2930 Dr. Kathrin Saar 87: Timoféeff-Ressovsky-Haus Room: 0.06 ksaar@mdc-berlin.de +49 30 9406-3534 Technical Assistants Susanne Blachut 87: Timoféeff-Ressovsky-Haus Room: 0.50 s.Blachut@mdc-berlin.de +49 30 9406-3269 Mathias Gerhard 87: Timoféeff-Ressovsky-Haus Room: 0.13 Oliver Hummel 87: Timoféeff-Ressovsky-Haus Room: 0.10 o.hummel@mdc-berlin.de Claudia Langnick 87: Timoféeff-Ressovsky-Haus Room: 0.50 claudia.langnick@mdc-berlin.de +49 30 9406-2527 Dr. Giannino Patone 87: Timoféeff-Ressovsky-Haus Room: 0.10 Giannino.Patone@mdc-berlin.de +49 30 9406-3441 Sabine Schmidt 87: Timoféeff-Ressovsky-Haus Room: 0.22 PhD student Barbara Bellomo 87: Timoféeff-Ressovsky-Haus Room: 0.13 Barbara.Bellomo@mdc-berlin.de +49 30 9406-2531 Nikita Shyam Dewani 87: Timoféeff-Ressovsky-Haus Room: 0.17 Nikita.Dewani@mdc-berlin.de +49 30 9406-2930 Johannes Greiner 87: Timoféeff-Ressovsky-Haus Room: 0.13 Johannes.Greiner@mdc-berlin.de +49 30 9406-2531 Laura Anne Liebig 87: Timoféeff-Ressovsky-Haus Room: 0.13 LauraAnne.Liebig@mdc-berlin.de +49 30 9406-2531 Eric Lars-Helge Lindberg 87: Timoféeff-Ressovsky-Haus Room: 0.17 +49 30 9406-3430 Anna Myronova 87: Timoféeff-Ressovsky-Haus Room: 0.13 Anna.Myronova@mdc-berlin.de +49 30 9406-2531 Sandmann 87: Timoféeff-Ressovsky-Haus Room: 0.17 clara.sandmann@mdc-berlin.de +49 30 9406-2930 Jana Felicitas Schulz 87: Timoféeff-Ressovsky-Haus Room: 0.17 JanaFelicitas.Schulz@mdc-berlin.de +49 30 9406-3430 Nikolay Shvetsov 87: Timoféeff-Ressovsky-Haus Room: 0.13 Nikolay.Shvetsov@mdc-berlin.de +49 30 9406-2531 Graduate and Undergraduate Aliki Grammatikaki 87: Timoféeff-Ressovsky-Haus Room: 0.17 Aliki.Grammatikaki@mdc-berlin.de Juan Li 87: Timoféeff-Ressovsky-Haus Room: 0.50 Juan.Li@mdc-berlin.de
Publications December 01, 2022 in NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert November 11, 2022 in Nat Commun pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation O. Boix M. Martinez S. Vidal M. Giménez-Alejandre L. Palenzuela L. Lorenzo-Sanz L. Quevedo O. Moscoso J. Ruiz-Orera P. Ximénez-Embún N. Ciriaco P. Nuciforo C. Stephan-Otto Attolini M.M. Albà J. Muñoz T.V. Tian I. Varela A. Vivancos S. Ramón Y Cajal P. Muñoz C. Rivas M. Abad October 19, 2022 in Circulation Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage M. Ercu M.B. Mücke T. Pallien L. Markó A. Sholokh C. Schächterle A. Aydin A. Kidd S. Walter Y. Esmati B.J. McMurray D.F. Lato D.Y. Sunaga-Franze P.H. Dierks B.I.M. Flores R. Walker-Gray M. Gong C. Merticariu K. Zühlke M. Russwurm T. Liu T.U.P. Batolomaeus S. Pautz S. Schelenz M. Taube H. Napieczynska A. Heuser J. Eichhorst M. Lehmann D.C. Miller S. Diecke F. Qadri E. Popova R. Langanki M.A. Movsesian F.W. Herberg S.K. Forslund D.N. Müller T. Borodina P.G. Maass S. Bähring N. Hübner M. Bader E. Klussmann October 06, 2022 in Mol Cel SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA S. Maharana S. Kretschmer S. Hunger X. Yan D. Kuster S. Traikov T. Zillinger M. Gentzel S. Elangovan P. Dasgupta N. Chappidi N. Lucas K.I. Maser H. Maatz A. Rapp V. Marchand Y.T. Chang Y. Motorin N. Hubner G. Hartmann A.A. Hyman S. Alberti M.A. Lee-Kirsch October 03, 2022 in Comput Struct Biotechnol J Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes S.A. Ansari W. Dantoft J. Ruiz-Orera A.P. Syed S. Blachut S. van Heesch N. Hübner N.H. Uhlenhaut October 01, 2022 in Hum Mutat Biallelic variants in WARS1 cause a highly variable neurodevelopmental syndrome and implicate a critical exon for normal auditory function S.J. Lin B. Vona H.M. Porter M. Izadi K. Huang Y. Lacassie J.A. Rosenfeld S. Khan C. Petree T.A. Ali N. Muhammad S.A. Khan N. Muhammad P. Liu M.L. Haymon F. Rüschendorf I.K. Kong L. Schnapp N. Shur L. Chorich L. Layman T. Haaf E. Pourkarimi H.G. Kim G.K. Varshney September 29, 2022 in PLoS ONE Aging-regulated TUG1 is dispensable for endothelial cell function A.T. Gimbel S. Koziarek K. Theodorou J.F. Schulz L. Stanicek V. Kremer T. Ali S. Günther S. Kumar H. Jo N. Hübner L. Maegdefessel S. Dimmeler S. van Heesch R.A. Boon August 11, 2022 in Eur J Hum Genet Identification of novel genes whose expression in adipose tissue affects body fat mass and distribution: an RNA-Seq and Mendelian Randomization study S. Konigorski J. Janke G. Patone M.M. Bergmann C. Lippert N. Hübner R. Kaaks H. Boeing T. Pischon August 05, 2022 in Science Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies D. Reichart E.L. Lindberg H. Maatz A.M.A. Miranda A. Viveiros N. Shvetsov A. Gärtner E.R. Nadelmann M. Lee K. Kanemaru J. Ruiz-Orera V. Strohmenger D.M. DeLaughter G. Patone H. Zhang A. Woehler C. Lippert Y. Kim E. Adami J.M. Gorham S.N. Barnett K. Brown R.J. Buchan R.A. Chowdhury C. Constantinou J. Cranley L.E. Felkin H. Fox A. Ghauri J. Gummert M. Kanda R. Li L. Mach B. McDonough S. Samari F. Shahriaran C. Yapp C. Stanasiuk P.I. Theotokis F.J. Theis A. van den Bogaerdt H. Wakimoto J.S. Ware C.L. Worth P.J.R. Barton Y.A. Lee S.A. Teichmann H. Milting M. Noseda G.Y. Oudit M. Heinig J.G. Seidman N. Hubner C.E. Seidman August 04, 2022 in Mol Cell A high-resolution map of human RNA translation S.P. Chothani E. Adami A.A. Widjaja S.R. Langley S. Viswanathan C.J. Pua N.T. Zhihao N. Harmston G. D'Agostino N. Whiffin W. Mao J.F. Ouyang W.W. Lim S. Lim C.Q.E. Lee A. Grubman J. Chen J.P. Kovalik K. Tryggvason J.M. Polo L. Ho S.A. Cook O.J.L. Rackham S. Schafer Pagination Current page 1 Page 2 Page 3 Page 4 … Next page ›› Last page Last »
December 01, 2022 in NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert
November 11, 2022 in Nat Commun pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation O. Boix M. Martinez S. Vidal M. Giménez-Alejandre L. Palenzuela L. Lorenzo-Sanz L. Quevedo O. Moscoso J. Ruiz-Orera P. Ximénez-Embún N. Ciriaco P. Nuciforo C. Stephan-Otto Attolini M.M. Albà J. Muñoz T.V. Tian I. Varela A. Vivancos S. Ramón Y Cajal P. Muñoz C. Rivas M. Abad
October 19, 2022 in Circulation Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage M. Ercu M.B. Mücke T. Pallien L. Markó A. Sholokh C. Schächterle A. Aydin A. Kidd S. Walter Y. Esmati B.J. McMurray D.F. Lato D.Y. Sunaga-Franze P.H. Dierks B.I.M. Flores R. Walker-Gray M. Gong C. Merticariu K. Zühlke M. Russwurm T. Liu T.U.P. Batolomaeus S. Pautz S. Schelenz M. Taube H. Napieczynska A. Heuser J. Eichhorst M. Lehmann D.C. Miller S. Diecke F. Qadri E. Popova R. Langanki M.A. Movsesian F.W. Herberg S.K. Forslund D.N. Müller T. Borodina P.G. Maass S. Bähring N. Hübner M. Bader E. Klussmann
October 06, 2022 in Mol Cel SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA S. Maharana S. Kretschmer S. Hunger X. Yan D. Kuster S. Traikov T. Zillinger M. Gentzel S. Elangovan P. Dasgupta N. Chappidi N. Lucas K.I. Maser H. Maatz A. Rapp V. Marchand Y.T. Chang Y. Motorin N. Hubner G. Hartmann A.A. Hyman S. Alberti M.A. Lee-Kirsch
October 03, 2022 in Comput Struct Biotechnol J Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes S.A. Ansari W. Dantoft J. Ruiz-Orera A.P. Syed S. Blachut S. van Heesch N. Hübner N.H. Uhlenhaut
October 01, 2022 in Hum Mutat Biallelic variants in WARS1 cause a highly variable neurodevelopmental syndrome and implicate a critical exon for normal auditory function S.J. Lin B. Vona H.M. Porter M. Izadi K. Huang Y. Lacassie J.A. Rosenfeld S. Khan C. Petree T.A. Ali N. Muhammad S.A. Khan N. Muhammad P. Liu M.L. Haymon F. Rüschendorf I.K. Kong L. Schnapp N. Shur L. Chorich L. Layman T. Haaf E. Pourkarimi H.G. Kim G.K. Varshney
September 29, 2022 in PLoS ONE Aging-regulated TUG1 is dispensable for endothelial cell function A.T. Gimbel S. Koziarek K. Theodorou J.F. Schulz L. Stanicek V. Kremer T. Ali S. Günther S. Kumar H. Jo N. Hübner L. Maegdefessel S. Dimmeler S. van Heesch R.A. Boon
August 11, 2022 in Eur J Hum Genet Identification of novel genes whose expression in adipose tissue affects body fat mass and distribution: an RNA-Seq and Mendelian Randomization study S. Konigorski J. Janke G. Patone M.M. Bergmann C. Lippert N. Hübner R. Kaaks H. Boeing T. Pischon
August 05, 2022 in Science Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies D. Reichart E.L. Lindberg H. Maatz A.M.A. Miranda A. Viveiros N. Shvetsov A. Gärtner E.R. Nadelmann M. Lee K. Kanemaru J. Ruiz-Orera V. Strohmenger D.M. DeLaughter G. Patone H. Zhang A. Woehler C. Lippert Y. Kim E. Adami J.M. Gorham S.N. Barnett K. Brown R.J. Buchan R.A. Chowdhury C. Constantinou J. Cranley L.E. Felkin H. Fox A. Ghauri J. Gummert M. Kanda R. Li L. Mach B. McDonough S. Samari F. Shahriaran C. Yapp C. Stanasiuk P.I. Theotokis F.J. Theis A. van den Bogaerdt H. Wakimoto J.S. Ware C.L. Worth P.J.R. Barton Y.A. Lee S.A. Teichmann H. Milting M. Noseda G.Y. Oudit M. Heinig J.G. Seidman N. Hubner C.E. Seidman
August 04, 2022 in Mol Cell A high-resolution map of human RNA translation S.P. Chothani E. Adami A.A. Widjaja S.R. Langley S. Viswanathan C.J. Pua N.T. Zhihao N. Harmston G. D'Agostino N. Whiffin W. Mao J.F. Ouyang W.W. Lim S. Lim C.Q.E. Lee A. Grubman J. Chen J.P. Kovalik K. Tryggvason J.M. Polo L. Ho S.A. Cook O.J.L. Rackham S. Schafer
News Press Release No. 48 October 19, 2022 Berlin No heart damage despite hypertension An overactive enzyme that causes an inherited form of high blood pressure also appears to protect against hypertension-induced cardiac damage. A team of researchers from the Max Delbrück Center, ECRC, and DZHK led by Enno Klußmann explains in the journal Circulation how this could fundamentally change the way hearts can be protected from damage. Press Release No. 36 August 04, 2022 Berlin How pathogenic gene variants lead to heart failure Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports in “Science”. MDC researcher Norbert Hübner is one of the senior authors. Press Release No. 32 July 13, 2022 Berlin Unchartered territory in the human genome An international consortium brings together 7,200 segments of the human genome that are virtually unexplored and presents a roadmap for integrating them into genome databases in “Nature Biotechnology”. They could hold information about what sets humans apart from other animals. Science December 01, 2021 Towards a better understanding of heart failure The heart can get weak in different ways. One form of the disease, heart failure with preserved ejection fraction (HFpEF), continues to be extremely difficult to treat. MDC researchers are involved in a new Collaborative Research Center, where they aim to change this and develop therapeutic approaches. Science November 10, 2021 Loss of control in heart muscle cells Titin is the largest protein in the human body which takes on a central role in muscle fibers. A DZHK team now reports in „Science Translational Medicine“ how mutations in the titin gene can cause a disease of the heart muscle, dilated cardiomyopathy. Press Release No. 43 August 30, 2021 Berlin A cell atlas of the pediatric heart After providing funding for single-cell analysis of adult hearts, the Chan Zuckerberg Initiative is now supporting the creation of a cell atlas of children’s hearts. An international team led by Christine Seidman of Harvard University and Norbert Hübner of the MDC is again among the funded networks. Press Release No. 39 July 05, 2021 Berlin A glitch in the heart’s protein factory MDC researchers have discovered a previously unknown cause of cardiac hypertrophy. As they report in the journal “Genome Biology”, genetic variation results in heart cell ribosomes not working properly. This disrupts protein production, which in turn causes the heart to grow too large. Press Release No. 48 October 29, 2020 Berlin Not all hearts are the same An international research team recently created the first atlas of the human heart. Now the scientists want to add a new dimension to the project: diversity. They are being supported by an additional Seed Networks grant from the Chan Zuckerberg Initiative. Press Release No. 42 September 24, 2020 Berlin An in-depth atlas of the heart Researchers from three continents have produced a first extensive draft of a cell atlas of the human heart to understand how this vital organ functions and to shed light on what goes wrong in cardiovascular disease. As the team reports in Nature, it reveals a huge cellular and molecular diversity. Press Release No. 18 April 23, 2020 Berlin Likely Entrypoints for SARS-CoV-2 Two specific cell types in the nose have been identified as likely initial infection points for the novel coronavirus that causes COVID-19. Using data from the Human Cell Atlas, scientists discovered that goblet and ciliated cells in the nose have high levels of the entry proteins that SARS-CoV-2 uses to get into our cells. Pagination Current page 1 Page 2 Page 3 Page 4 Next page ›› Last page Last »
Press Release No. 48 October 19, 2022 Berlin No heart damage despite hypertension An overactive enzyme that causes an inherited form of high blood pressure also appears to protect against hypertension-induced cardiac damage. A team of researchers from the Max Delbrück Center, ECRC, and DZHK led by Enno Klußmann explains in the journal Circulation how this could fundamentally change the way hearts can be protected from damage.
Press Release No. 36 August 04, 2022 Berlin How pathogenic gene variants lead to heart failure Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports in “Science”. MDC researcher Norbert Hübner is one of the senior authors.
Press Release No. 32 July 13, 2022 Berlin Unchartered territory in the human genome An international consortium brings together 7,200 segments of the human genome that are virtually unexplored and presents a roadmap for integrating them into genome databases in “Nature Biotechnology”. They could hold information about what sets humans apart from other animals.
Science December 01, 2021 Towards a better understanding of heart failure The heart can get weak in different ways. One form of the disease, heart failure with preserved ejection fraction (HFpEF), continues to be extremely difficult to treat. MDC researchers are involved in a new Collaborative Research Center, where they aim to change this and develop therapeutic approaches.
Science November 10, 2021 Loss of control in heart muscle cells Titin is the largest protein in the human body which takes on a central role in muscle fibers. A DZHK team now reports in „Science Translational Medicine“ how mutations in the titin gene can cause a disease of the heart muscle, dilated cardiomyopathy.
Press Release No. 43 August 30, 2021 Berlin A cell atlas of the pediatric heart After providing funding for single-cell analysis of adult hearts, the Chan Zuckerberg Initiative is now supporting the creation of a cell atlas of children’s hearts. An international team led by Christine Seidman of Harvard University and Norbert Hübner of the MDC is again among the funded networks.
Press Release No. 39 July 05, 2021 Berlin A glitch in the heart’s protein factory MDC researchers have discovered a previously unknown cause of cardiac hypertrophy. As they report in the journal “Genome Biology”, genetic variation results in heart cell ribosomes not working properly. This disrupts protein production, which in turn causes the heart to grow too large.
Press Release No. 48 October 29, 2020 Berlin Not all hearts are the same An international research team recently created the first atlas of the human heart. Now the scientists want to add a new dimension to the project: diversity. They are being supported by an additional Seed Networks grant from the Chan Zuckerberg Initiative.
Press Release No. 42 September 24, 2020 Berlin An in-depth atlas of the heart Researchers from three continents have produced a first extensive draft of a cell atlas of the human heart to understand how this vital organ functions and to shed light on what goes wrong in cardiovascular disease. As the team reports in Nature, it reveals a huge cellular and molecular diversity.
Press Release No. 18 April 23, 2020 Berlin Likely Entrypoints for SARS-CoV-2 Two specific cell types in the nose have been identified as likely initial infection points for the novel coronavirus that causes COVID-19. Using data from the Human Cell Atlas, scientists discovered that goblet and ciliated cells in the nose have high levels of the entry proteins that SARS-CoV-2 uses to get into our cells.
Jobs Starts November 28, 2022 secretary October 20, 2022 Fremdsprachensekretär*in (m/w/d) Genetics and Genomics of Cardiovascular Diseases Für die Arbeitsgruppe „Genetik und Genomik von Herz-Kreislauferkrankungen“ am Max-Delbrück-Centrum für Molekulare Medizin (MDC) in Berlin-Buch wird zum nächstmöglichen Zeitpunkt (01.12.2022 oder früher) ein*e Fremdsprachensekretär*in in Vollzeit gesucht.
Starts November 28, 2022 secretary October 20, 2022 Fremdsprachensekretär*in (m/w/d) Genetics and Genomics of Cardiovascular Diseases Für die Arbeitsgruppe „Genetik und Genomik von Herz-Kreislauferkrankungen“ am Max-Delbrück-Centrum für Molekulare Medizin (MDC) in Berlin-Buch wird zum nächstmöglichen Zeitpunkt (01.12.2022 oder früher) ein*e Fremdsprachensekretär*in in Vollzeit gesucht.
Prof. Dr. Norbert Hübner Contact nhuebner@mdc-berlin.de Phone: +49 30 9406-2530 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Robert-Rössle-Straße 10 13125 Berlin, Deutschland Building 87, Room 0.09 Norbert Hübner is a DZHK Principal Investigator
