OmicPrep

Challenge

Current omics-based diagnostics are usually restricted to a single molecular layer. Large amounts of input material masks rare cell populations in disease. This leads to missed therapeutic opportunities when the full multi-omic landscape is not analysed.

Solution

OmicPrep is a novel extraction device for high-throughput, ultra-low-volume multi-omic sample preparation with integrated metabolite derivatization. It enables clinicians and researchers to probe every unit of information from a human cell.

Currently the only device for ultra-low volume integrated multi-omics
Captures all levels of biology in a single workflow – no need for sample splitting
Maximises value from precious low volume clinical samples reducing cost and time
Scalable for high-throughput sample analysis and miniaturisation for microfluidics
Supporting software and data analysis pipelines for stream-lined end-user data interpretation

Development status

TRL3‑4
Proteins detected down to single-cell level
Metabolic kinetics of drug action characterised in head and neck cancer cells
RNA profiled from same sample analysed for metabolomics and proteomics

Applications:

Profiling of cell lines (e.g. Beta-cell maturity)
Uncovering early metabolic and molecular changes – earlier diagnosis and detection
Real-time monitoring of treatment response and disease progression