Model of cAMP signaling microdomain

Klußmann Lab

Anchored Signalling

Profile

The Anchored Signalling group aims to elucidate molecular mechanisms conferring specificity to cAMP signalling

Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that directs a plethora of cellular processes. In the cardiovascular system, cAMP, for example modulates contractility of cardiac myocytes and participates in the control of blood pressure through vascular smooth muscle cell

Team

Research

Protein kinase A (PKA) is a ubiquitous serine/threonine kinase that controls a large variety of cellular functions. Specificity of PKA action is achieved by controlling its cellular localization through A-kinase anchoring proteins (AKAPs). AKAPs bind PKA through an amphipathic α-helical structure (RII-binding domain), which interacts directly with the dimerization and docking (D/D) domain of regulatory subunit dimers. Besides PKA, AKAPs directly bind other signalling proteins such as other protein kinases, protein phosphatases, phosphodiesterases (PDEs), GTPases, adaptor proteins and substrate proteins of PKA through unique interacting domains. Thus AKAPs coordinate multi-protein signalling complexes establishing compartmentalized signalling.

Our aim is to elucidate the role and the molecular mechanisms of compartmentalized cAMP/PKA signalling in controlling vasopressin-mediated water reabsorption in renal principal cells and cardiac myocyte contractility.

Publications

PD Dr. Enno Klußmann
PD Dr. Enno Klußmann
Permanent Fellow
Contact
Phone: 030 9406-2596
Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Robert-Rössle-Str. 10
13092 Berlin, Deutschland
Building 31.1, Room 2016.1