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Meyer Lab

RNA Structure and Transcriptome Regulation

Our group develops dedicated computational methods for investigating how RNA structural features and RNA-RNA interactions regulate the expression of protein-coding and non-coding genes.

Our primary focus are the transcriptomes of eukaryotic model organisms such as the fruit fly (Drosophila melanogaster), the mouse (Mus musculus) and the human (Homo sapiens).

For this, we aim to combine computational analyses developed by us with large scale data sets generated using state-of-the-art high-throughput sequencing and investigation protocols.

Research

We develop dedicated computational methods and algorithms for investigating how RNA structural features and RNA-RNA interactions regulate the expression of protein-coding and non-coding genes.

Our primary focus are the transcriptomes of eukaryotic model organisms such as the fruit fly (Drosophila melanogaster), the mouse (Mus musculus) and the human (Homo sapiens). To investigate those, we combine computational analysis pipelines developed by us with large scale data sets generated using state-of-the-art high-throughput sequencing and investigation protocols.

Publications

in Front Microbiol

Sugar metabolism of the first thermophilic planctomycete thermogutta terrifontis: comparative genomic and transcriptomic approaches.

A.G. Elcheninov et al.
in Methods

In silico methods for co-transcriptional RNA secondary structure prediction and for investigating alternative RNA structure expression

I.M. Meyer
in Nucleic Acids Res

A comprehensive comparison of general RNA-RNA interaction prediction methods

D. Lai et al.
in RNA Biol

Genome-wide identification and characterisation of tissue-specific RNA editing events in D. melanogaster and their potential role in regulating alternative splicing

A. Mazloomian et al.
in RNA Biol

Four RNA families with functional transient structures

J.Y. Zhu et al.
in Nucleic Acids Res

e-RNA: a collection of web servers for comparative RNA structure prediction and visualisation

D. Lai et al.
in RNA

On the importance of cotranscriptional RNA structure formation

D. Lai et al.
in Nucleic Acids Res

Transient RNA structure features are evolutionarily conserved and can be computationally predicted

J.Y.A. Zhu et al.
in Nucleic Acids Res

COFOLD: an RNA secondary structure prediction method that takes co-transcriptional folding into account

J.R. Proctor et al.
in RNA Biol

The hok mRNA family

A. Steif et al.

Research Topics