Disease-related Research

Researchers at the the Deutsches Herzzentrum der Charité and the Max Delbrück Center have identified a unique metabolic fingerprint in the hearts of patients with HFpEF and obesity. The findings, which were published in “Cardiovascular Research,” point to new drug targets.

Joint press release by the Max Delbrück Center and the Helmholtz Centre for Infection Research One...

In aggressive lymphomas, inflammatory messengers reprogram the “conductors” of the immune system, causing lymph node structure to collapse. A team led by Simon Haas describes in “Nature Cancer” this process for the first time using single-cell and spatial analyses.

At the Einstein Center for Early Disease Interception, researchers from twelve Berlin institutions will be pooling their expertise to explore new approaches to prevention, long before symptoms appear, and bring them quickly into practice. The center opens today with a ceremony.

Researchers at the Max Delbrück Center and Charité – Universitätsmedizin Berlin show that adipose tissue amplifies gut inflammation in Crohn’s disease. The study, published in the “Journal of Clinical Investigation,” also reveals how genetic changes in immune cells may contribute to the disease.

Checkpoint inhibitors help fight cancer but increase the risk of heart disease. An interdisciplinary team, including researchers from the Max Delbrück Center, is investigating how the therapy can be made safer. The Hector Foundation is supporting the project with €1.3 million.

Researchers have uncovered the molecular details of how ancient viral DNA controls a gene linked to preeclampsia. The study, published in “Genome Biology,” builds on previous research and may lead to a diagnostic test to identify preeclampsia risk much earlier.

Helmholtz-funded projects highlight a new focus at the Max Delbrück Center on biomedical engineering. By combining biomedicine, artificial intelligence, and engineering, basic research can be more quickly translated into therapies.

Researchers at the Max Delbrück Center have uncovered how a bacterial metabolite produced in the gut regulates heart function through specific brain cells. The findings, published in “Circulation Research,” reveal a new gut-brain-heart axis and point to potential therapies for hypertension and heart failure.

MRI scans often struggle to capture clear images of deep or delicate tissues. Researchers at the Max Delbrück Center now report in “Advanced Materials” a new lightweight antenna that boosts image quality and may shorten scan times ¬– without changing existing MRI machines.