Jonathan Jantsch: Local tissue microenvironment & metabolism in host defense

You are cordially invited to the talk ‘Local tissue microenvironment & metabolism in host defense’ by guest speaker Prof. Jonathan Jantsch, MD, from the Institute for Medical Microbiology, Immunology, and Hygiene, and Center for Molecular Medicine Cologne, University Hospital Cologne and Faculty of Medicine, University of Cologne. 

In his talk, Jonathan Jantsch will present new findings on the interaction between neurotransmitter metabolism and innate antimicrobial defenses. He will present evidence that tissue perfusion is a key driver of the resolution of infectious lesions, relying on a coordinated immunovascular response mediated by T cell-derived interferon-γ.

The Jantsch Lab investigates how tissue-specific conditions and metabolism influence effective antimicrobial immunity. The lab's work focuses on how local metabolism and electrolyte balance influence host–pathogen interactions, particularly in innate immune cells, especially macrophages, in models of cutaneous leishmaniasis and Salmonella infection. To address these questions, the lab combines molecular, immunological, bacteriological and parasitological methods with advanced technologies such as inductively coupled plasma optical emission spectroscopy (ICP-OES), oxygen luminescence imaging and laser speckle contrast analysis for tissue perfusion, as well as mass spectrometric techniques.

If you can't make it in person, please join via zoom.