Modulating psoriasis microbiome: a clinical trial on mare's milk impact

BACKGROUND: Psoriasis is a chronic inflammatory disease with a complex and multifactorial origin. Previous studies have shown that the gut microbiome can influence immune responses and may play a role in disease development. This study aimed to explore the effect of mare’s milk as a dietary prebiotic in patients with psoriasis. RESULTS: We conducted a non-randomised controlled trial including 50 adults. The intervention group received a daily dose of 60 mg freeze-dried mare’s milk for 12 weeks. Stool samples were collected at baseline and at weeks 6 and 12 to evaluate microbiome changes. At baseline, microbial patterns were consistent with the dysbiosis typically described in psoriasis. After mare’s milk intake, some of these alterations appeared to improve, with the most notable shift being an increase in Actinobacteriota abundance. Patients in the intervention group also showed reduced psoriasis severity. CONCLUSIONS: Mare’s milk supplementation may help support a healthier gut microbiome and could offer therapeutic benefits in psoriasis.