folder

Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome

Authors

  • T.E. Willnow
  • A. Christ

Journal

  • Pflugers Archiv

Citation

  • Pflugers Arch 469 (7-8): 907-916

Abstract

  • Megalin (or LRP2) is an endocytic receptor that plays a central role in embryonic development and adult tissue homeostasis. Loss of this receptor in congenital or acquired diseases results in multiple organ dysfunctions, including forebrain malformation (holoprosencephaly) and renal reabsorption defects (renal Fanconi syndrome). Here, we describe current concepts of the mode of receptor action that include co-receptors and a repertoire of different ligands, and we discuss how these interactions govern functional integrity of the kidney and the brain, and cause disease when defective.


DOI

doi:10.1007/s00424-017-1992-0