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Seeing elephants and drinking water from a porcelain vase - a case of septin-7 antibody-associated encephalitis presenting as a severe disorganized psychosis

Authors

  • Arnim Johannes Gaebler
  • Friederike A Arlt
  • Madeleine Scharf
  • Stefan Wolking
  • Yvonne Weber
  • Simone Tauber
  • Marieluise Kirchner
  • Philipp Mertins
  • Christian Boy
  • Irene Neuner
  • Thomas Frodl
  • Ludger Tebartz van Elst
  • Harald Prüss
  • Ana Novakovic

Journal

  • Translational Psychiatry

Citation

  • Transl Psychiatry 16 (1): 71

Abstract

  • Identifying autoimmune encephalitis (AIE) in patients with predominant psychiatric symptoms poses a diagnostic challenge for psychiatrists and neurologists, especially when CSF and MRI findings are inconclusive. We report a case of septin-7 AIE presenting as steroid-responsive psychosis, whose definite diagnosis could only be made years after onset.


DOI

doi:10.1038/s41398-026-03877-y