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Synaptic plasticity in the subiculum

Authors

  • J. Behr
  • C. Wozny
  • P. Fidzinski
  • D. Schmitz

Journal

  • Progress in Neurobiology

Citation

  • Prog Neurobiol 89 (4): 334-342

Abstract

  • The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.


DOI

doi:10.1016/j.pneurobio.2009.09.002