Alternative methods to animal studies

Organoids have to be fed and cared for continuously so that they can mature. So far, it is mostly a manual process – not suitable for industrial drug screening. Now, the European Research Council (ERC) has awarded Mina Gouti a Proof of Concept Grant to tackle scalability and reproducibility.

Jana Wolf draws on experimental data and the growing knowledge of cellular mechanisms to translate disease processes into mathematical models. Her models aim to represent the complexity of life as realistically as possible and to help develop therapies that are precisely tailored to the patient.

Research to improve human health is currently not possible without animal testing. At the same time, scientists are searching for alternatives. In the current episode of the Berlin Research 50 (BR50) podcast, Thomas Prinzler discusses progress and limitations with Berlin experts.

When the bacterium Helicobacter pylori infects the stomach, it causes inflammation and increases the risk of stomach cancer. In “Nature Communications” researchers from Charité and MDC elucidate changes which occur inside the gastric glands during an infection. The findings may herald a new treatment target in stomach cancer.

The new Einstein Center for Alternative Methods in Biomedical Research is officially starting its work. The Einstein Foundation will support the Berlin-based facility to the tune of around €5.3 million through the end of 2026. The funds are being provided by the State of Berlin. The MDC is involved with several projects.

When the cells’ power plants don’t function properly, life expectancy is low. Otherwise, little is known about Leigh syndrome. Using organoids, researchers in Düsseldorf and Berlin have now created the first human model for studying this rare disease. They are presenting their work in “Nature Communications”.

The European Research Council (ERC) awarded Dr. Mina Gouti a €2.8 million Consolidator Grant to further develop miniature neuromuscular organoids for studying neuromuscular development and diseases. It was the second honor in as many weeks; she was also named an EMBO Young Investigator for her work.

At MDC, we do research to promote human health and well-being. In our labs we employ cell cultures, organoids and computer models. We seek and develop alternatives to animal experiments. It remains a fact that, biomedical research is not possible without animal experiments. Our researchers tell us why.

The board of the Einstein Foundation approved the preliminary stage of a new Einstein Center for the development of alternative methods for animal testing in biomedical research. The aim of the planned center is to reduce or replace animal experiments. It will be established in cooperation with the MDC.

Dr. Jana Wolf heads the Mathematical Modeling of Cellular Processes Lab at the MDC. On June 15 she will begin a professorship at FU Berlin. She looks forward to exchanging expertise and ideas with her new colleagues – and to leveraging this knowledge to develop new medical models.