Research Highlights

Sometimes a tumor suddenly starts growing rapidly or becomes resistant to cancerdrugs. This can be caused by a cancer gene “striking out on its own” in ring shapes. ECRC-scientist Anton Henssen described how these DNA rings arise and continue to develop in the journal “Nature Genetics”.

Genes are not the only drivers of evolution. The iconic fins of skates are caused by changes in the non-coding parts of the genome and its three-dimensional structure, a research team including Darío Lupiáñez at the Max Delbrück Center reports in “Nature”.

A team of scientists led by Martin Janz and Klaus Rajewsky at the Max Delbrück Center has successfully generated genetically defined mouse models for two subtypes of multiple myeloma. These models will contribute to a better understanding of how the disease develops in humans. The team has now published their findings in the journal PNAS.

Hypertension can damage the heart, brain, and blood vessels. The immune system plays an important role in this process, Suphansa Sawamiphak from the Max Delbrück Center reports in Cardiovascular Research. The study, using zebrafish, found that inflammation causes macrophages to damage blood vessels instead of protecting them.

Evolutionarily young miniproteins are unique in humans, and researchers have recently discovered thousands of them. Writing in Molecular Cell, Norbert Hübner and colleagues from the BIH and other institutions describe the origins of these tiny proteins and explain that they probably influence important cellular processes.

Researchers from the Max Delbrück Center have found a region of the brain that is responsible for our perception of temperature when we touch things. The paper, which appears in “Nature”, reports the discovery of a ‘thermal cortex’ located in a posterior region of the insular cortex.

The signaling molecules of the immune system should trigger a response only where necessary. To prevent a life-threatening spread to the rest of the body, connective tissue can absorb these molecules like a sponge. A team led by Thomas Blankenstein presents this mechanism in “Nature Immunology.

Researchers suspect that neurodegenerative diseases occur when messenger RNA (mRNA) goes astray in the neuron. With a new method, Marina Chekulaeva is able to identify “zipcodes” that assign a destination to mRNAs. She has now presented her method in the journal Nature Neuroscience.

Combining single-cell data with a self-learning algorithm reveals how structural changes in chromosomes can trigger cancer. This new method could pave the way for personalized cancer treatments, writes a team led by Ashley Sanders in “Nature Biotechnology”.

A group of international researchers – among them Stephan Mathas from the ECRC – has found that changing a single segment of the genome causes a previously unknown immunodeficiency in humans. The paper, which appears in Science Immunology, reports the discovery of a point mutation in the transcription factor IRF4.