Kugel in 3D Landschaft

15th Berlin Summer Meeting - Exploring Disease Landscapes

Exploring Disease Landscapes

Harnessing single-cell multi-omics, imaging and computational models

Dear friends and colleagues,

After two virtual Berlin Summer Meetings, we are excited to host the 15th Berlin Summer Meeting: “Exploring Disease Landscapes”, which will once again take place on-site in the BIMSB research building on 8-9 September 2022. 

The meeting will showcase approaches towards understanding disease from different angles, including imaging, investigation of gene regulatory mechanisms, data science, and single cell technologies. 

In addition to a selection of keynote speakers, all participants are invited to submit an abstract to be considered for a presentation. Early career scientists are particularly encouraged to apply. 

To utilize the full potential of finally being able to get together in person again, the program will feature interactive formats as well as opportunities to network and socialize.

We hope to be able to welcome you to the 15th Berlin Summer Meeting this September!

The BSM2022 Scientific Committee

Peran Hayes
Anna Oliveras Martinez

Luiz Gustavo Teixeira Alves
Emanuel Wyler


Attendance of the Berlin Summer Meeting 2022 is free of charge, but registration until 1 September 2022 is required for on-site attendance.

Since space in the large conference room is limited, we’d ask you to be mindful of resources and cancel your on-site participation if you should no longer be able to attend (via e-mail bsm@mdc-berlin.de).

Call for abstracts

We invite all Berlin Summer Meeting 2022 participants to submit an abstract for consideration for a selected talk (approximately 20 min plus 10 min discussion). Early career researchers are particularly encouraged to apply.

Abstracts may be composed of a text with a maximum length of 2500 characters including spaces. The deadline for abstract submission is 21 August 2022.

Selected speakers will be notified by 28 August 2022.


Hannoversche Straße 28
10115 Berlin




Preliminary program

Thursday, September 8, 2022

10:00 am -  10:15 am             Welcome address by Nikolaus Rajewsky

Session 1: Gene Regulation

10:15 am – 11:00 am             Noam Stern Ginossar

Weizmann Institute of Science, Rehovot, Israel

mRNA translation – a tug of war during viral infection

11:00 am – 11:20 am             Konrad Chudzik

Max Planck Institute for Molecular Genetics, Berlin, Germany

Multi-omic single-cell profiling reveals nuclear envelope release precedes gene activation during mouse embryogenesis

11:20 am – 11:40 am             Melyssa Minto

Duke University, Computational Biology and Bioinformatics, Durham, NC, USA

Multiomic analysis reveal novel co-factors in Zic-mediated gene regulation in the cerebellum

11:40 am – 12 pm                  Euphy Wu

University of North Carolina at Chapel Hill, Department of Biostatistics, NC, USA

Detecting isoform-level allelic imbalance accounting for inferential uncertainty

12:00 pm -1:45 pm                 Lunch break

Session 2: Single Cell Biology

1:45 pm – 2:30 pm                 Simon Haas

                                               Berlin Institute of Health/BIMSB, MDC

Unlocking the mysteries of blood generation by integrated multimodal single-cell analyses


2:30 pm – 2:50 pm                 Ahmed N. Hegazy     

Charité-Universitätsmedizin Berlin, Department of Gastroenterology, Infectious Diseases and Rheumatology/ Berlin Institute of Health, Core Unit Bioinformatics (CUBI)

Multi-omics profiling of the circulating immune cell landscape in inflammatory bowel disease identifies circulating predictors for non-response to anti-integrin treatment

2:50 pm – 3:10 pm                 Eric Lindberg


Pathogenic variants damage cell composition and single-cell transcription in cardiomyopathies

3:10 pm – 3:30 pm                 Maja-Celine Cwikla

BIMSB, MDC/Charité – Universitätsmedizin Berlin

Intercellular extrachromosomal DNA copy number heterogeneity in neuroblastoma

3:45 pm – 5:00 pm                 Round tables with speakers and PIs (on site only)

5:00 pm – 8:00 pm                 BBQ on the rooftop terrace

Friday, September 9. 2022

Session 3: Understanding Disease

10:15 am – 11:00 am             Susanne Wegmann

                                               DZNE, Berlin, Germany

                                               Condensates of Tau – a nexus between function and pathology

11:00 am – 11:20 am             Henri Niskanen

Max Planck Institute for Molecular Genetics, Berlin, Germany

Disruption of nucleolar phase separation in human genetic disease

11:20 am – 11:40 am             Anna Oliveras

                                               BIMSB, MDC

Tau and ApoE coalescence drives lipid dysregulation in Alzheimer’s disease

11:40 am – 12:00 pm             Janita Mintcheva

                                                BIMSB, MDC

Cell state transitions and dynamics in zebrafish heart regeneration

12:00 am – 1:45 pm               Lunch break

12:15 pm – 1:30 pm               Breakout session (on site only)

Session 4: Organoids

1:45pm – 2:30 pm                  Markus Morkel

                                               Charité – Universitätsmedizin Berlin

Oncogenes, signaling networks and cell states in colorectal cancer organoids

2:30 pm – 2:50 pm                 Kimberly Hartl

Charité – Universitätsmedizin Berlin/BIMSB, MDC

P53 knock-out cells are locked in a regenerative state in the context of colitis

2:50 pm – 3:10 pm                 Julian Heuberger

Charité – Universitätsmedizin Berlin, Department of Hepatology and Gastroenterology/BIMSB, MDC

                                               IFN-gamma primes colonic epithelia for regeneration

3:10 pm – 3:30 pm                 Milad Rezvani

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA/Charité Universitätsmedizin Berlin, Department of Pediatrics, Division of Gastroenterology, Nephrology and Metabolic Medicine/Berlin Institute of Health, Center for Regenerative Therapies

Trajectory Lineage Analyses of Human Hemato-Hepatogenesis Organoids from Human Pluripotent Stem Cells

3:30 pm                                  Closing remarks


The BSM2022 Scientific Committee

Peran Hayes
Anna Oliveras Martinez

Luiz Gustavo Teixeira Alves
Emanuel Wyler