MDC Lab Coats

Stein Lab

Translational Oncology of Solid Tumors


Metastatic dissemination of primary tumors is directly linked to patient survival and critically limits successful therapy in many tumor entities. Our translational concepts aim at the identification of key molecules in tumor progression and metastasis for improved prognosis and therapy of solid cancers.

We newly discovered the gene MACC1 (metastasis associated in colon cancer 1) and identified the metastasis inducer S100A4 as a Wnt signaling target gene. Transcriptional targets or protein binding partners thereof were found as new diagnostic, prognostic and predictive key players for tumor progression and metastasis.Biomarker development is done in established and patient-derived 3D cultures, cell line-derived and patient-derived xenograft (PDX) and newly generated genetically engineered mouse (GEMM) models.

We exploit this knowledge for improved disease prognosis and treatment response prediction in tissue and blood of cancer patients. Novel therapeutic approaches are currently tested in clinical trials to treat patients with metastatic disease using small molecule inhibitors acting on these biomarkers.




Group Leader

Senior Scientist


Technical Assistants

PhD student


MACC1 induces cell motility, proliferation, and scattering in cell culture and metastasis in mouse models. It acts as transcription factor regulating e.g. Met expression, and also interacts with proteins via e.g. its SH3 domain or proline-rich motif. By microarrays we identified the MACC1 transcriptome. By HTS using the MACC1 promoter we identified first transcriptional MACC1 inhibitors. By MS we identified the MACC1 interactome and phospho-interactome for novel interventions.


Prof. Dr. Ulrike Stein
Prof. Dr. Ulrike Stein
Phone: 9406-3432
Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Robert-Rössle-Str. 10
13092 Berlin, Deutschland
Building 31.1, Room 4017

Research Topics