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Gouti Lab

Stem Cell Modeling of Development and Disease

Profile

We use human and mouse pluripotent stem cells to model and understand normal and pathological development of the neuromuscular system.

Following the cues from mouse embryonic development we have recently succeeded in generating spinal cord neurons from a neuromesodermal progenitor population (NMP).

This in vitro system opens up new opportunities for the study and treatment of neuromuscular diseases due to its great advantage of simultaneously generating cell types of neural and mesodermal origin in the “dish”.

Our focus is understanding how these two tissues are generated in space and time during development, how they interact and, intriguingly, how defects in early development of these tissues can lead to different predisposition to disease in the adult life.

To address these questions we are using gain and loss of gene function approaches (Crispr/Cas9 system), single cell genomics (RNA-seq) as well as live cell imaging techniques on human and mouse pluripotent stem cells.

For more information please visit Gouti Lab Website

Team

Publications

Profile Image · Gouti
Dr. Mina Gouti
Group Leader
Contact
Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Robert-Rössle-Str. 10
13092 Berlin, Germany
27: Walter-Friedrich House
Room 012
 
(030) 9406 2610
 
Secretariat
 
Beate Valeske
(030) 9406 2507
27: Walter-Friedrich House
Room 243